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Volume 16 Issue 1
February 2001
    Citation: HUANG Ping, SHEN Gui—zhang, NI Han—zhong, ZHOU Hui-qiong. M olecular Evolution of Guangdong Influenza Virus Isolates in Influenza Outbreak in 1996 .VIROLOGICA SINICA, 2001, 16(1) : 1-6.
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    M olecular Evolution of Guangdong Influenza Virus Isolates in Influenza Outbreak in 1996

    • 1.

      Center for Desease Control and Prevention of Guangdong Province，Guangzhou 510300．China

    • Available online: 05 February 2001
    • It was demonstrated that there vcas significantly antigenic drift in the influenza virus strains from Guangdong in 1996 I r was the mokcular basis of the variation oll A、B、C、D and E domain en— coded by HA gene，especially on A、C and E domain while the change of receptor binding domain played the slight roles in the 1996 influenza outbreak 1n the other hand．the variation of No 145 and No 193 encoded by klA gene resuked in biological—feature changes of epidemical influenzu iso~．ates． which could be iso[ated and cultured by MDCK cell—lines。but difficultly by embryonated．eggs
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      M olecular Evolution of Guangdong Influenza Virus Isolates in Influenza Outbreak in 1996

      • 1. Center for Desease Control and Prevention of Guangdong Province，Guangzhou 510300．China

      Abstract: It was demonstrated that there vcas significantly antigenic drift in the influenza virus strains from Guangdong in 1996 I r was the mokcular basis of the variation oll A、B、C、D and E domain en— coded by HA gene，especially on A、C and E domain while the change of receptor binding domain played the slight roles in the 1996 influenza outbreak 1n the other hand．the variation of No 145 and No 193 encoded by klA gene resuked in biological—feature changes of epidemical influenzu iso~．ates． which could be iso[ated and cultured by MDCK cell—lines。but difficultly by embryonated．eggs

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