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Volume 16 Issue 3
June 2001
    Citation: LI Yong, YANG ZI, LIU Jian-jun, GUO Guang-shong, XIAO Hong, WEN Li. L6565 M ouse Leukemia Induced by L6565 Murine Leukemi a Virus .VIROLOGICA SINICA, 2001, 16(3) : 261-264.
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    L6565 M ouse Leukemia Induced by L6565 Murine Leukemi a Virus

    • 1.

      I贵阳医学院免疫学教研室．贵州贵阳550004~ 2．武汉大学医学院病毒学研究所．湖北武汉43007 3武汉太学中南医院病理科，湖北武汉430071

    • Available online: 05 September 2001
    • Suckling mice were inoculated with L6565 blLV for researehlng the pathogeny of L6565 moL!se Leukemia Afterinoeulatica~，叽emol3y,eⅧ sacrificed r3r week．Theperipheral blood，thymus，[ymp畸node， spleen and liver weTe removed from l’lflOIl~．|I11e tissues were used to observe tIl0 pathological changes and to detect1．6565 MLV RNA by RT-PC~ ．At 3～5 weeks postinoeulation．routine thynms．1ymphy node began to swell，And IIIOU~ leukemia was indueed at 10～12 weeks postinoeulatlon．L6565 MLV RNA Ⅵ∞ detected first inⅡl0use thymus and s een at the se~nd week曲er inoculadon，and the viral RNA *,vaS detected in rnanv ／131iillle oigalls 8s time goes on．The results sh㈣d that L6565 l／lOUSe leukemia COIlld be jnduced by L6565 naalne leukemia、TirllS，and it is related to the transformation of lvmph0cyte by 1．6565 MLV．
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      L6565 M ouse Leukemia Induced by L6565 Murine Leukemi a Virus

      • 1. I贵阳医学院免疫学教研室．贵州贵阳550004~ 2．武汉大学医学院病毒学研究所．湖北武汉43007 3武汉太学中南医院病理科，湖北武汉430071

      Abstract: Suckling mice were inoculated with L6565 blLV for researehlng the pathogeny of L6565 moL!se Leukemia Afterinoeulatica~，叽emol3y,eⅧ sacrificed r3r week．Theperipheral blood，thymus，[ymp畸node， spleen and liver weTe removed from l’lflOIl~．|I11e tissues were used to observe tIl0 pathological changes and to detect1．6565 MLV RNA by RT-PC~ ．At 3～5 weeks postinoeulation．routine thynms．1ymphy node began to swell，And IIIOU~ leukemia was indueed at 10～12 weeks postinoeulatlon．L6565 MLV RNA Ⅵ∞ detected first inⅡl0use thymus and s een at the se~nd week曲er inoculadon，and the viral RNA *,vaS detected in rnanv ／131iillle oigalls 8s time goes on．The results sh㈣d that L6565 l／lOUSe leukemia COIlld be jnduced by L6565 naalne leukemia、TirllS，and it is related to the transformation of lvmph0cyte by 1．6565 MLV．

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