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Volume 17 Issue 2
April 2002
    Citation: XIAO Chun—hui, YANG Zhan—qiu, XIAO Hong, XIONG Zeng-hui, W EN Li, HOU W ei, LIU Hong. Research of Antiviral Activity of Pcnciclovir to Herpesvirus in vitro .VIROLOGICA SINICA, 2002, 17(2) : 102-105.
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    Research of Antiviral Activity of Pcnciclovir to Herpesvirus in vitro

    • 1.

      1 The Institute of Virology theMedical School Wuhan University，Hubei Wuhan 430071

    • 2.

      Medicine Industry of Hubei Wuhan 430000．China

    • Available online: 05 April 2002
    • In order to evaluate the cytotoxicity and antiherpesvlral activity of penciclovir，the antiher— pesvlral effect of PCV was investigated by observing eytopathie efect(CPE)and the change of viral infectious titre jn cells infected with herpesvirus，antiviral index and treatment index，The result shows the 50％ toxicity dose(TD50)。f PCV to HEL ceil and Hep-2 ceil are 105．2txg／mL and 85．1~g／mL respectively；the average 50％ inhibitory coneertration(IC50)of PCV to HSV一1，HSV一2，VZV．HSV一1 wU strain are 21 78fxg／mL，20 15~tg／mL，23．19~g／ml and 17，875g／mL respectively：teat index are 5 84，6 31．5，49 and 7 1 1 respectively．It is indicated that penciclovir is an effective anti—herpesvirus compound in vitro，
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      Research of Antiviral Activity of Pcnciclovir to Herpesvirus in vitro

      • 1. 1 The Institute of Virology theMedical School Wuhan University，Hubei Wuhan 430071
      • 2. Medicine Industry of Hubei Wuhan 430000．China

      Abstract: In order to evaluate the cytotoxicity and antiherpesvlral activity of penciclovir，the antiher— pesvlral effect of PCV was investigated by observing eytopathie efect(CPE)and the change of viral infectious titre jn cells infected with herpesvirus，antiviral index and treatment index，The result shows the 50％ toxicity dose(TD50)。f PCV to HEL ceil and Hep-2 ceil are 105．2txg／mL and 85．1~g／mL respectively；the average 50％ inhibitory coneertration(IC50)of PCV to HSV一1，HSV一2，VZV．HSV一1 wU strain are 21 78fxg／mL，20 15~tg／mL，23．19~g／ml and 17，875g／mL respectively：teat index are 5 84，6 31．5，49 and 7 1 1 respectively．It is indicated that penciclovir is an effective anti—herpesvirus compound in vitro，

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