Citation: ZHOU Jing-jiao, LIU Jian-jun “, XU Shun—xian, LIU Jun, WEI Yun. p53 Expression and Genetic Evidence for Virus Infection in Cervical Carcinoma .VIROLOGICA SINICA, 2003, 18(3) : 197-200.

p53 Expression and Genetic Evidence for Virus Infection in Cervical Carcinoma

  • Available online: 18 June 2003
  • Abstract: Wle examined 121 Specimens of exfoliated cells and tissue of cervix for the presence of肿V一16/18 an d HSV一2 DNA by PCR.At the same time,we analysised 76 specimens from tissue ofcervix for the expression of p53 by immunohistochemical assay.The HPV一16/18 was found in 19(61.3%)of 31 cervical carcinoma,in 9(22.5%)of 40 chronic cervicitis,in 3(6.O%)of 50 normaluterine cervix.The positive rate of HSV一2 was 32.3% (10/31),2O.O% (8,4O)and 4.0% (2/50).1 emixed infection rate of肿V 16/18 an d HSV一2 was 16.1% in cervical carcinoma.The rates of positiveexpression ofp53 was found to have a gradient of crescendo in the tissues of chronic cervicitis.CIN an dcervical carcinoma.Wle found that cerv ical carcinoma is strongly related witll HPV一16/18 infection.Asynergetic action may OCCUr between HPv an d HSV一2 infections in the oncogenesis of cervicalcarcinoma.Th e overepression of p53 appears to be closely associated with the development of cervicalcan cer.Th ere is a matter ofclinical significan ce on the prevention an d treatment ofcervical carcinoma.

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    p53 Expression and Genetic Evidence for Virus Infection in Cervical Carcinoma

    • 1. 1.Department of microbiology,Sun Yat-sen University,Guangzhou 510080
    • 2. 1nstitute of l~rology,Medical College, Wuhan University,Wuhan 430071
    • 3. The FirstHospitalofWuhan University

    Abstract: Abstract: Wle examined 121 Specimens of exfoliated cells and tissue of cervix for the presence of肿V一16/18 an d HSV一2 DNA by PCR.At the same time,we analysised 76 specimens from tissue ofcervix for the expression of p53 by immunohistochemical assay.The HPV一16/18 was found in 19(61.3%)of 31 cervical carcinoma,in 9(22.5%)of 40 chronic cervicitis,in 3(6.O%)of 50 normaluterine cervix.The positive rate of HSV一2 was 32.3% (10/31),2O.O% (8,4O)and 4.0% (2/50).1 emixed infection rate of肿V 16/18 an d HSV一2 was 16.1% in cervical carcinoma.The rates of positiveexpression ofp53 was found to have a gradient of crescendo in the tissues of chronic cervicitis.CIN an dcervical carcinoma.Wle found that cerv ical carcinoma is strongly related witll HPV一16/18 infection.Asynergetic action may OCCUr between HPv an d HSV一2 infections in the oncogenesis of cervicalcarcinoma.Th e overepression of p53 appears to be closely associated with the development of cervicalcan cer.Th ere is a matter ofclinical significan ce on the prevention an d treatment ofcervical carcinoma.

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