Citation: YAN Yin, CHEN Xiao, YAN Yuan, fan g, YAN Xiao. Cytomegalovirus Infection Induces Variation of Cell Cycle and Cyclin E in M RC-5 cells .VIROLOGICA SINICA, 2003, 18(4) : 311-314.

Cytomegalovirus Infection Induces Variation of Cell Cycle and Cyclin E in M RC-5 cells

  • Available online: 05 August 2003
  • Abstract:In this Paper we repoaed that Cytomegalovirus infection induced high levels of Cyclin E, increases of Cyclin E/cdk2 activity,leading to cell cycle arrest.By 72h postinfection(at a multiplicity of infection of 1 0 PFU/per cel1),29% of the cells was S phase,69% of the cells in Gz/M phase,only 2% of the cells in Go/G1 phase by flow cytometry an alysis.By 20h postinfection,the levels of cyclinE in infected M RC.5 cells were eightfold greater than those in mock-infectcd cells by ELISA an alysis.The cyclin E/cdk2 kinase activities in HCM V-infected M RC一5 cells were relative to the levels of cyclinE essentially.

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    Cytomegalovirus Infection Induces Variation of Cell Cycle and Cyclin E in M RC-5 cells

    • 1. The Institute of Virology of the Medical College of Wuhan University,Wuhan 430071,China

    Abstract: Abstract:In this Paper we repoaed that Cytomegalovirus infection induced high levels of Cyclin E, increases of Cyclin E/cdk2 activity,leading to cell cycle arrest.By 72h postinfection(at a multiplicity of infection of 1 0 PFU/per cel1),29% of the cells was S phase,69% of the cells in Gz/M phase,only 2% of the cells in Go/G1 phase by flow cytometry an alysis.By 20h postinfection,the levels of cyclinE in infected M RC.5 cells were eightfold greater than those in mock-infectcd cells by ELISA an alysis.The cyclin E/cdk2 kinase activities in HCM V-infected M RC一5 cells were relative to the levels of cyclinE essentially.

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