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Volume 18 Issue 4
August 2003
    Citation: SUN Xiao, XIE Jian-ruing, ZHOU Shi-xin, XIE Xue-ying, LU Zu-hong. Genome Comparison Between SARS—associated coronavirus andOther Coronaviruses .VIROLOGICA SINICA, 2003, 18(4) : 335-339.
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    Genome Comparison Between SARS—associated coronavirus andOther Coronaviruses

    • 1.

      Department ofBiological Science＆Medical Engineering，Southeast University,Nanfing 210096，China

    • Available online: 05 August 2003
    • Abstract：The genome sequences of SARS．associated coronavirus (SARS．COV)were compared witIlother Coronaviruses．Similar sequences were found by searching biomolecular databases．Sequenceanalysis showed that SARS．CoV had similar genomi c organization and structural proteins whilecompared with other Coronaviruses．SARS．CoV is related to other known Coronaviruses．But therewere some specific sequences in SARS．CoV genome．Th e virulence of SARS may deftve fromvaxi~ions of ORF l a an d S protein an d the specificity of some nonstructural proteins．Th e result of wordfrequency an alysis indicated that SARS．CoV does not closely resemble an y of kn own Coronaviruses．
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      Genome Comparison Between SARS—associated coronavirus andOther Coronaviruses

      • 1. Department ofBiological Science＆Medical Engineering，Southeast University,Nanfing 210096，China

      Abstract: Abstract：The genome sequences of SARS．associated coronavirus (SARS．COV)were compared witIlother Coronaviruses．Similar sequences were found by searching biomolecular databases．Sequenceanalysis showed that SARS．CoV had similar genomi c organization and structural proteins whilecompared with other Coronaviruses．SARS．CoV is related to other known Coronaviruses．But therewere some specific sequences in SARS．CoV genome．Th e virulence of SARS may deftve fromvaxi~ions of ORF l a an d S protein an d the specificity of some nonstructural proteins．Th e result of wordfrequency an alysis indicated that SARS．CoV does not closely resemble an y of kn own Coronaviruses．

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