Citation: YAN Ran, SHEN Chao, LEI Lei, ZHENG Cong—yi, XIAO Geng—fu, GUO De—yin, ZHU Ymg, YAN Hui一min. SARS-CoV Infection Induces Apoptosis of Vero E6 .VIROLOGICA SINICA, 2003, 18(6) : 541-543.

SARS-CoV Infection Induces Apoptosis of Vero E6

  • Available online: 25 December 2003
  • Abstract:To determine if SARS—associated coronavirus(SARS—CoV)induces apoptosis.we studied the SARS—CoV infected Vero E6 cells by agarose gel electrophoresis.indirect fluorescent staining for infection an d Hoechst 33528 staining for nuclei,as well as by flow cytometry.It was found that SARS—C0V infected Vero E6 cells showed typical apoptosis characteristics.Au the typical apoptotic ceHs were in late—infection period.Most of the cells with cytopathic effect(CPE)showed nuclei witll condensed chromatin or fragmented into apoptotic bodies.It was suggested that SARS—CoV infection induces apoptosis of Vero E6.

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    SARS-CoV Infection Induces Apoptosis of Vero E6

    • 1. College of Life Sciences,Wuhan University,Wuhan 430072,China

    Abstract: Abstract:To determine if SARS—associated coronavirus(SARS—CoV)induces apoptosis.we studied the SARS—CoV infected Vero E6 cells by agarose gel electrophoresis.indirect fluorescent staining for infection an d Hoechst 33528 staining for nuclei,as well as by flow cytometry.It was found that SARS—C0V infected Vero E6 cells showed typical apoptosis characteristics.Au the typical apoptotic ceHs were in late—infection period.Most of the cells with cytopathic effect(CPE)showed nuclei witll condensed chromatin or fragmented into apoptotic bodies.It was suggested that SARS—CoV infection induces apoptosis of Vero E6.

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