SARS-CoV Infection Induces Apoptosis of Vero E6
Abstract: Abstract:To determine if SARS—associated coronavirus(SARS—CoV)induces apoptosis.we studied the SARS—CoV infected Vero E6 cells by agarose gel electrophoresis.indirect fluorescent staining for infection an d Hoechst 33528 staining for nuclei,as well as by flow cytometry.It was found that SARS—C0V infected Vero E6 cells showed typical apoptosis characteristics.Au the typical apoptotic ceHs were in late—infection period.Most of the cells with cytopathic effect(CPE)showed nuclei witll condensed chromatin or fragmented into apoptotic bodies.It was suggested that SARS—CoV infection induces apoptosis of Vero E6.