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Volume 19 Issue 4
August 2004
    Citation: ZHAO Wei-guang, ZHANG Jian-lin, WU Jian-guo, ZHU Ying, LI Yan, ZHU Zhong-chao, LIU Zhi-su. Co-expression of HBx and Hepsin Promotes Replication of HBV .VIROLOGICA SINICA, 2004, 19(4) : 345-348.
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    Co-expression of HBx and Hepsin Promotes Replication of HBV

    • 1.

      1. College of Life Sciences, Wuhan University/Key Laboratory of the Ministry of Education for Virology, Wuhan 430072, China

    • 2.

      Zhohgnan Hospital, School of Medicine, Wuhan University, Wuhan 430071, China

    • Corresponding author: WU Jian-guo, 
    • Available online: 25 August 2004
    • Entire ORF of Hepsin was isolated from adjacent live tissue of HCC with RT-PCR. Hepsin gene was inserted into expressing vector pCMV-tag-HS. The recombinant vector pCMV-tag-HS was co-transfected into liver tumor line Hep G2.2.1.5 with plasmid encoding HBx protein. The results indicated that co-expression of HBx and Hepsin increased the expressing level of viral proteins and the copy number of HBV, which implicated that the association of HBx and Hepsin promoted the replication of HBV.
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      Co-expression of HBx and Hepsin Promotes Replication of HBV

        Corresponding author: WU Jian-guo,
      • 1. 1. College of Life Sciences, Wuhan University/Key Laboratory of the Ministry of Education for Virology, Wuhan 430072, China
      • 2. Zhohgnan Hospital, School of Medicine, Wuhan University, Wuhan 430071, China

      Abstract: Entire ORF of Hepsin was isolated from adjacent live tissue of HCC with RT-PCR. Hepsin gene was inserted into expressing vector pCMV-tag-HS. The recombinant vector pCMV-tag-HS was co-transfected into liver tumor line Hep G2.2.1.5 with plasmid encoding HBx protein. The results indicated that co-expression of HBx and Hepsin increased the expressing level of viral proteins and the copy number of HBV, which implicated that the association of HBx and Hepsin promoted the replication of HBV.

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