eNOS Gene (894G/T) Polymorphisms Among Patients Infected With HBV

To characterize the relationship between exon7 of eNOS gene(position 894G/T) polymorphism and clinical subgroups infected with HBV.The genotype was analyzed by using method of polymerase chain reaction(PCR),enzyme restriction after PCR amplification,and agrose gel electrophresis.Results show that statistic differences of genotype and allele frequency exist in the patients between AsC(asymptomatic carrier)and any other subgroups;between AsC+CHB(Chronic hepatitis B)and SHB(Severe hepatitis B)+LC(Liver cirrosis) subgroups.Logistic regression analysis supports that G/G genotype of exon7 is more succeptiable to develop Asc state than G/T or T/T genotype.So exon7 of eNOS gene(position 894G/T) polymophism exists among the people infected with HBV,espescially G/G genotype of exon7 is might more succeptiable to develop Asc state than G/T or T/T genotype.