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Volume 20 Issue 6
December 2005
    Citation: XU Yan-ming, MA Jun, HONG Kun-xue, DENG Xiao-ling, LIU Yong-chao, RUAN Yu-hua, XING Hui, ZHANG Zhi-yuan, XU Xiao-hu, SHAO Yi-ming. HLA-B Alleles Associated with Susceptibility or Resistance to Human Immunodeficiency Virus Type 1 in a Xinjiang Uygur Population, China .VIROLOGICA SINICA, 2005, 20(6) : 594-599.
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    HLA-B Alleles Associated with Susceptibility or Resistance to Human Immunodeficiency Virus Type 1 in a Xinjiang Uygur Population, China

    • 1.

    • Available online: 20 December 2005
    • Host genetic factors, such as human leukocyte antigen (HLA) alleles, are important in Human immunodeficiency virus ( HIV) infection and its progression to AIDS. HLA class I genes, especially highly polymorphic HLA-B genes, are involved in the activation of HLA-restricted cytotoxic T lymphocytes (CTLs) against HIV, and thus control susceptibility to or protect against this virus. The present study was aimed to determine the distribution of HLA-B alleles in the Chinese Uygur ethnic group and its association with HIV infection. One hundred ten healthy control (HIV negative) and 128 HIV positive Chinese Xinjiang Uygur ethnic individuals were used in this study. HLA typing for B allele was performed by polymerase chain reaction (PCR) with sequence-specific primers (SSP). Hardy-Weinberg equilibrium was calculated using POPGENE software for the healthy control group. The HLA-B frequency of each alleic was compared between the patients and the controls using the chi-square test. In HIV-1-pos-itive group, gene frequen
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      HLA-B Alleles Associated with Susceptibility or Resistance to Human Immunodeficiency Virus Type 1 in a Xinjiang Uygur Population, China

      • 1. 

      Abstract: Host genetic factors, such as human leukocyte antigen (HLA) alleles, are important in Human immunodeficiency virus ( HIV) infection and its progression to AIDS. HLA class I genes, especially highly polymorphic HLA-B genes, are involved in the activation of HLA-restricted cytotoxic T lymphocytes (CTLs) against HIV, and thus control susceptibility to or protect against this virus. The present study was aimed to determine the distribution of HLA-B alleles in the Chinese Uygur ethnic group and its association with HIV infection. One hundred ten healthy control (HIV negative) and 128 HIV positive Chinese Xinjiang Uygur ethnic individuals were used in this study. HLA typing for B allele was performed by polymerase chain reaction (PCR) with sequence-specific primers (SSP). Hardy-Weinberg equilibrium was calculated using POPGENE software for the healthy control group. The HLA-B frequency of each alleic was compared between the patients and the controls using the chi-square test. In HIV-1-pos-itive group, gene frequen

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