Citation: FANG Qin, LIU Juan, BAI Zhi-qiang, KANG Tao, HE Zhi-heng, HU Zhi-hong, Jiang Gao. Seroprevalence of Kaposi’s sarcoma-associated Herpesvirus in the General Population from Hubei province .VIROLOGICA SINICA, 2006, 21(2) : 97-101.

Seroprevalence of Kaposi’s sarcoma-associated Herpesvirus in the General Population from Hubei province

  • Corresponding author: FANG Qin, 
  • Available online: 20 March 2006
  • Kaposi’s sarcoma-associated herpes-virus (KSHV), also known as Human herpesvirus 8 (HHV-8) is etiologically linked to the development of Kaposi’s sarcoma(KS), the most commonly found cancers in patients with AIDS. Extensive epidemiology studies have shown that the epidemiology of KSHV mimics that of KS displaying distinct geographic distribution patterns with low prevalence in North America and Europe, medium prevalence in Eastern European and Mediterranean regions, and high prevalence in some regions in Africa. However, the prevalence of KSHV infection in Asia, especially in China remains undefined. To investigate the prevalence of KSHV infection from the general population in the Han nationality from Hubei Province, we examined 560 sera specimens using an ELISA-based assay that measured antibodies to KSHV lytic antigen small capsid protein ORF65. The overall KSHV seroprevalence in this population was 5.2%. There was no difference between male and female (5.7% vs 4.5%, P = 0.542). On the other hand, the age distribution pattern was peculiar. KSHV-seropositive rate was significantly higher in subjects younger than 10 years old (P = 0.006, OR = 6.692, 95% CI: 1.710-26.198). Excluding this group, KSHV-seropositive rate showed a trend of increase with age but it was not statistically significant. Our results indicate that the prevalence of KSHV infection is similar to those reported in Western countries in the adult population. However, the relative high prevalence of KSHV infection among the young children is reminiscent of some African regions, and might implicate specific mode of transmission in this population.

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    Seroprevalence of Kaposi’s sarcoma-associated Herpesvirus in the General Population from Hubei province

      Corresponding author: FANG Qin,
    • 1. 1. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071
    • 2. Graduate School ,Chinese Academy of Sciences, Beijing 100039,China
    • 3. Children’s Cancer Research Institute and Departments of Pediatrics, Microbiology and Immunology, Molecular Medicine, and Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA

    Abstract: Kaposi’s sarcoma-associated herpes-virus (KSHV), also known as Human herpesvirus 8 (HHV-8) is etiologically linked to the development of Kaposi’s sarcoma(KS), the most commonly found cancers in patients with AIDS. Extensive epidemiology studies have shown that the epidemiology of KSHV mimics that of KS displaying distinct geographic distribution patterns with low prevalence in North America and Europe, medium prevalence in Eastern European and Mediterranean regions, and high prevalence in some regions in Africa. However, the prevalence of KSHV infection in Asia, especially in China remains undefined. To investigate the prevalence of KSHV infection from the general population in the Han nationality from Hubei Province, we examined 560 sera specimens using an ELISA-based assay that measured antibodies to KSHV lytic antigen small capsid protein ORF65. The overall KSHV seroprevalence in this population was 5.2%. There was no difference between male and female (5.7% vs 4.5%, P = 0.542). On the other hand, the age distribution pattern was peculiar. KSHV-seropositive rate was significantly higher in subjects younger than 10 years old (P = 0.006, OR = 6.692, 95% CI: 1.710-26.198). Excluding this group, KSHV-seropositive rate showed a trend of increase with age but it was not statistically significant. Our results indicate that the prevalence of KSHV infection is similar to those reported in Western countries in the adult population. However, the relative high prevalence of KSHV infection among the young children is reminiscent of some African regions, and might implicate specific mode of transmission in this population.

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