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    Citation: Jialu Zheng, Yutong Wei, Guan-Zhu Han. The diversity and evolution of retroviruses: perspectives from viral “fossils” .VIROLOGICA SINICA.
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    The diversity and evolution of retroviruses: perspectives from viral “fossils”

    • Jiangsu Key Laboratory for Microbes and Functional Genomics, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China

    • Corresponding author: Guan-Zhu Han, guanzhu@njnu.edu.cn
    • Received Date: 18 August 2021
      Accepted Date: 12 October 2021
      Published Date: 22 October 2021
    • Retroviruses exclusively infect vertebrates, causing a variety of diseases. The replication of retroviruses requires reverse transcription and integration into host genomes. When infecting germline cells, retroviruses become inherited vertically, forming endogenous retroviruses (ERVs). ERVs document past viral infections, providing molecular fossils for studying the evolutionary history of retroviruses. In this review, we summarize the recent advances in understanding the diversity and evolution of retroviruses from the perspectives of viral fossils, and discuss the effects of ERVs on the evolution of host biology.
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      The diversity and evolution of retroviruses: perspectives from viral “fossils”

        Corresponding author: Guan-Zhu Han, guanzhu@njnu.edu.cn
      • Jiangsu Key Laboratory for Microbes and Functional Genomics, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China
      • Received Date: 18 August 2021
      • Accepted Date: 12 October 2021
      • Published Date: 22 October 2021

      Abstract: Retroviruses exclusively infect vertebrates, causing a variety of diseases. The replication of retroviruses requires reverse transcription and integration into host genomes. When infecting germline cells, retroviruses become inherited vertically, forming endogenous retroviruses (ERVs). ERVs document past viral infections, providing molecular fossils for studying the evolutionary history of retroviruses. In this review, we summarize the recent advances in understanding the diversity and evolution of retroviruses from the perspectives of viral fossils, and discuss the effects of ERVs on the evolution of host biology.

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