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Volume 23 Issue 6
December 2008
    Citation: Zhi-qiang Bai, Xiu-fen Lei, Lin-ding Wang, Shou-jiang Gao. Identification and Function of MicroRNAs Encoded by Herpesviruses .VIROLOGICA SINICA, 2008, 23(6) : 459-472.  http://dx.doi.org/10.1007/s12250-008-2997-9
    shu

    Identification and Function of MicroRNAs Encoded by Herpesviruses

    • 1.

      Tumor Virology Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China

    • 2.

      Graduate School of the Chinese Academy of Sciences, Beijing 100039, China

    • 3.

      Tumor Virology Program, Greehey Children's Cancer Research Institute and Department of Pediatrics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

    • Corresponding author: Lin-ding Wang, wangld@wh.iov.cn
      Shou-jiang Gao, gaos@uthscsa.edu
    • Received Date: 14 August 2008
      Accepted Date: 18 September 2008
      Available online: 01 December 2008

      Fund Project: National Science Foundation of China A Type B Outstanding Abroad Young Scientist AwardNational Institutes of Health CA096512National Institutes of Health CA124332Open Research Fund Program of the State Key Laboratory of Virology of China 2007013The Knowledge Innovation Program of the Chinese Academy of Sciences Chinese Academy of Sciences 0702121YJ1National Institutes of Health CA119889National Institutes of Health DE017333

    • MicroRNAs (miRNAs) play important roles in eukaryotes, plants and some viruses. It is increasingly clear that miRNAs-encoded by viruses can affect the viral life cycle and host physiology. Viral miRNAs could repress the innate and adaptive host immunity, modulate cellular signaling pathways, and regulate the expression of cellular and viral genes. These functions facilitate viral acute and persistent infections, and have profound effects on the host cell survival and disease progression. Here, we discuss the miRNAs encoded by herpesviruses, and their regulatory roles involved in virus-host interactions.
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      Identification and Function of MicroRNAs Encoded by Herpesviruses

        Corresponding author: Lin-ding Wang, wangld@wh.iov.cn
        Corresponding author: Shou-jiang Gao, gaos@uthscsa.edu
      • 1. Tumor Virology Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
      • 2. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
      • 3. Tumor Virology Program, Greehey Children's Cancer Research Institute and Department of Pediatrics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
      • Received Date: 14 August 2008
      • Accepted Date: 18 September 2008
      Fund Project:  National Science Foundation of China A Type B Outstanding Abroad Young Scientist AwardNational Institutes of Health CA096512National Institutes of Health CA124332Open Research Fund Program of the State Key Laboratory of Virology of China 2007013The Knowledge Innovation Program of the Chinese Academy of Sciences Chinese Academy of Sciences 0702121YJ1National Institutes of Health CA119889National Institutes of Health DE017333

      Abstract: MicroRNAs (miRNAs) play important roles in eukaryotes, plants and some viruses. It is increasingly clear that miRNAs-encoded by viruses can affect the viral life cycle and host physiology. Viral miRNAs could repress the innate and adaptive host immunity, modulate cellular signaling pathways, and regulate the expression of cellular and viral genes. These functions facilitate viral acute and persistent infections, and have profound effects on the host cell survival and disease progression. Here, we discuss the miRNAs encoded by herpesviruses, and their regulatory roles involved in virus-host interactions.

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