Citation: Lei WANG, Xiao-ming REN, Jun-ji XING, AlanC. ZHENG. The Nucleolus and Viral Infection .VIROLOGICA SINICA, 2010, 25(3) : 151-157.  http://dx.doi.org/10.1007/s12250-010-3093-5

The Nucleolus and Viral Infection

  • Corresponding author: AlanC. ZHENG, zhengcf@wh.iov.cn
  • Received Date: 21 September 2009
    Accepted Date: 31 March 2010
    Available online: 01 June 2010

    Fund Project: Hubei province natural science foundation of innovation groups project 2008CDA013The startup fund of the hundred talents program of the Chinese academy of science 20071010141Open research fund program of the state key laboratory of virology of China 2009007National natural science foundation of China 30870120Open research fund program of the state key laboratory of virology of China 2007003

  • The nucleolus is a subnuclear structure of eukaryocytes. It was thought that nucleolus only participates in the biogenesis and processing of rRNA. However, more and more evidence shows that it has many other functions, such as tRNA precursor processing, stress sensing and it is also involved in gene silencing, senescence and cell cycle regulation. Here, we summarize the recent understandings about the nucleolar functions, the regulation of nucleolar localization of proteins and the role that the nucleolus plays in virus infection, in which some related studies of Herpes simplex virus type 1 (HSV-1) US11, UL24 and bovine herpesvirus-1 infected cell protein 27 (BICP27) carried out in our lab will also be included.

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    The Nucleolus and Viral Infection

      Corresponding author: AlanC. ZHENG, zhengcf@wh.iov.cn
    • 1. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
    • 2. The Department of Animal Science, Beijing University of Agriculture, Beijing 102206, China
    Fund Project:  Hubei province natural science foundation of innovation groups project 2008CDA013The startup fund of the hundred talents program of the Chinese academy of science 20071010141Open research fund program of the state key laboratory of virology of China 2009007National natural science foundation of China 30870120Open research fund program of the state key laboratory of virology of China 2007003

    Abstract: The nucleolus is a subnuclear structure of eukaryocytes. It was thought that nucleolus only participates in the biogenesis and processing of rRNA. However, more and more evidence shows that it has many other functions, such as tRNA precursor processing, stress sensing and it is also involved in gene silencing, senescence and cell cycle regulation. Here, we summarize the recent understandings about the nucleolar functions, the regulation of nucleolar localization of proteins and the role that the nucleolus plays in virus infection, in which some related studies of Herpes simplex virus type 1 (HSV-1) US11, UL24 and bovine herpesvirus-1 infected cell protein 27 (BICP27) carried out in our lab will also be included.