Citation: Viroj Wiwanitkit. Indinavir Resistance Evolution: a Comment .VIROLOGICA SINICA, 2011, 26(1) : 72-72.  http://dx.doi.org/10.1007/s12250-011-3173-6

Indinavir Resistance Evolution: a Comment

  • Corresponding author: Viroj Wiwanitkit, wviroj@yahoo.com
  • Received Date: 28 October 2010
    Accepted Date: 16 November 2010
    Available online: 01 February 2011

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    1. Choi J Y, Kwon O K, Choi S Y, et al. 2010. Drug susceptibility of human immunodeficiency virus type 1-derived pseudoviruses from treatment-experienced patients to protease inhibitors and reverse transcriptase inhibitors, using a modified single-round assay. J Clin Virol, [Oct 20. Epub ahead of print]

    2. Geng Q M, Li H P, Bao Z Y, et al. 2010. Indinavir resistance evolution in one human immunodeficiency virus type 1 infected patient revealed by single-genome amplification. Virol Sin, 25 (5): 316-328.
        doi: 10.1007/s12250-010-3122-4

    3. Pushkarev D, Neff N F, Quake S R. 2009. Single-molecule sequencing of an individual human genome. Nat Biotechnol, 27 (9): 847-852.
        doi: 10.1038/nbt.1561

    4. Rhee S Y, Taylor J, Fessel W J, et al. 2010. HIV-1 protease mutations and protease inhibitor cross-resistance. Animicrob Agents Chemother, 54 (10): 4253-4261.
        doi: 10.1128/AAC.00574-10

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    Indinavir Resistance Evolution: a Comment

      Corresponding author: Viroj Wiwanitkit, wviroj@yahoo.com
    • Wiwanitkit House, Bangkhae, Bangkok 10160, Thailand

    Abstract: 

    • Dear Editor,

      I read the recent report on HIV with a great interest[2]. Geng et al concluded that "Indinavir-resistance evolution was observed by single-genome amplification [2] " and "During the course of changing the regimen to incorporate Indinavir, the G73S mutation occurred and was combined with M46I/ L90M[2]." I have some points for discussion on this work. First, focusing on the single-genome amplification, although it is acceptable the false positive can still be detected[3]. It is interesting to compare the result from this Stanford HIV Drug Resistance Database-based study to modified phenotypic drug susceptibility assay-based study, which was reported to provide discordant result [1]. Second, it is interesting which biological process lead to the change of the resistant pattern on the passed time. The situation of cross resistance should also be investigated since it was reported to be common[4].

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