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Volume 28 Issue 1
February 2013
    Citation: Yun Wang, Xinwen Chen. How the Key Finds its Door – Identification of HBV Receptor .VIROLOGICA SINICA, 2013, 28(1) : 1-2.  http://dx.doi.org/10.1007/s12250-013-3301-1
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    How the Key Finds its Door – Identification of HBV Receptor

    • Skate Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, China

    • Corresponding author: Yun Wang, wangyun@wh.iov.cn
    • Received Date: 28 December 2012
      Accepted Date: 31 December 2012
      Available online: 01 February 2013
    • HBV is the predominant pathogen associated with hepatitis cases in China. Although the HBV replication mechanism has been extensively documented in recent years, the virus entry mechanism remains elusive; in particular, the HBV receptor has yet to be identified. Recently, a research team led by Dr. Wenhui Li finally identified Sodium taurocholate cotransporting polypeptide (NTCP) as the receptor for HBV infection of hepatocytes (Yan H, et al., 2012). This review highlights their research strategy, as well as the significance of the identification of the HBV receptor.
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      1. Barrera A, Guerra B, Notvall L and Lanford R E. 2005. Mapping of the hepatitis B virus pre-S1 domain involved in receptor recognition. J Virol, 79: 9786-9798.
          doi: 10.1128/JVI.79.15.9786-9798.2005

      2. De Falco S, Ruvoletto M G, Verdoliva A, Ruvo M, Raucci A, Marino M, Senatore S, Cassani G, Alberti A, Pontisso P and Fassina G. 2001. Cloning and expression of a novel hepatitis B virus-binding protein from HepG2 cells. J Biol Chem, 276: 36613-36623.
          doi: 10.1074/jbc.M102377200

      3. Deng Q, Zhai J W, Michel M L, Zhang J, Qin J, Kong Y Y, Zhang X X, Budkowska A, Tiollais P, Wang Y and Xie Y H. 2007. Identification and characterization of peptides that interact with hepatitis B virus via the putative receptor binding site. J Virol, 81: 4244-4254.
          doi: 10.1128/JVI.01270-06

      4. Engelke M, Mills K, Seitz S, Simon P, Gripon P, Schnolzer M and Urban S. 2006. Characterization of a hepatitis B and hepatitis delta virus receptor binding site. Hepatology, 43: 750-760.
          doi: 10.1002/hep.v43:4

      5. Glebe D, Urban S, Knoop E V, Cag N, Krass P, Grun S, Bulavaite A, Sasnauskas K and Gerlich W H. 2005. Mapping of the hepatitis B virus attachment site by use of infection-inhibiting preS1 lipopeptides and tupaia hepatocytes. Gastroenterology, 129: 234-245.
          doi: 10.1053/j.gastro.2005.03.090

      6. Gripon P, Cannie I and Urban S. 2005. Efficient inhibition of hepatitis B virus infection by acylated peptides derived from the large viral surface protein. J Virol, 79: 1613-1622.
          doi: 10.1128/JVI.79.3.1613-1622.2005

      7. Neurath A R, Strick N and Sproul P. 1992. Search for hepatitis B virus cell receptors reveals binding sites for interleukin 6 on the virus envelope protein. J Exp Med, 175: 461-469.
          doi: 10.1084/jem.175.2.461

      8. Schulze A, Schieck A, Ni Y, Mier W and Urban S. 2010. Fine mapping of pre-S sequence requirements for hepatitis B virus large envelope protein-mediated receptor interaction. J Virol, 84: 1989-2000.
          doi: 10.1128/JVI.01902-09

      9. Yan H, Zhong G, Xu G, He W, Jing Z, Gao Z, Huang Y, Qi Y, Peng B, Wang H, Fu L, Song M, Chen P, Gao W, Ren B, Sun Y, Cai T, Feng X, Sui J and Li W. 2012. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. elife, 1: e00049.

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      How the Key Finds its Door – Identification of HBV Receptor

        Corresponding author: Yun Wang, wangyun@wh.iov.cn
      • Skate Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, China
      • Received Date: 28 December 2012
      • Accepted Date: 31 December 2012

      Abstract: HBV is the predominant pathogen associated with hepatitis cases in China. Although the HBV replication mechanism has been extensively documented in recent years, the virus entry mechanism remains elusive; in particular, the HBV receptor has yet to be identified. Recently, a research team led by Dr. Wenhui Li finally identified Sodium taurocholate cotransporting polypeptide (NTCP) as the receptor for HBV infection of hepatocytes (Yan H, et al., 2012). This review highlights their research strategy, as well as the significance of the identification of the HBV receptor.

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