Serving the Society Since 1986
Advanced Search
Volume 30 Issue 3
June 2015
    Citation: Harrison P Nguyen, Hung Q Doan, Peter Rady, Stephen K Tyring. Cellular signaling in sinecatechins-treated external genital and perianal warts: unraveling the mechanism of action of a botanical therapy .VIROLOGICA SINICA, 2015, 30(3) : 214-217.  http://dx.doi.org/10.1007/s12250-014-3520-0
    shu

    Cellular signaling in sinecatechins-treated external genital and perianal warts: unraveling the mechanism of action of a botanical therapy

    cstr: 32224.14.s12250-014-3520-0
    • 1.

      Department of Dermatology, Baylor College of Medicine, Houston 77004, USA

    • 2.

      Department of Dermatology, University of Texas Houston Health Science Center, Houston 77004, USA

    • 3.

      Center for Clinical Studies, Houston 77004, USA

    • Corresponding author: Stephen K Tyring, styring@ccstexas.com, ORCID: 0000-0002-7771-6571
    • Published Date: 25 March 2015
      Available online: 01 June 2015
    • Taken together with our previous report, current results provide cursory evidence that the sinecatechins’ mechanism of action likely entails some degree of modulation of inflammatory and apoptotic processes, in particular, the NF-κB-pathway. It is possible that sinecatechins also upregulate the host immune response, since the only gene to be significantly upregulated in VR is the pro-lymphocytic IL2; however, further studies are needed to examine the exact pattern of immune regulation. Moreover, since no DEGs were identified in VNR in the prior report, the present study provides putative insight into the expression patterns of patients who are not responsive to sinecatechins.
    • 加载中

      1. Aisen P. 2004. Int J Biochem Cell Biol, 36: 2137-2143.
          doi: 10.1016/j.biocel.2004.02.007

      2. Baird DM. 2010. Expert Rev Mol Med, 12: e16.
          doi: 10.1017/S146239941000147X

      3. Fuessel-Haws AL, He Q, Rady PL, et al. 2004. J Virol Methods, 122: 87-93.
          doi: 10.1016/j.jviromet.2004.08.007

      4. James MA, Lee JH, Klingelhutz AJ. 2006. J Virol, 80: 5301-5307.
          doi: 10.1128/JVI.01942-05

      5. Liu M, Wang G, Gomez-Fernandez CR, et al. 2012. PLoS One, 7: e46410.
          doi: 10.1371/journal.pone.0046410

      6. McLaughlin-Drubin ME, Park D, Munger K. 2013. Proc Natl Acad Sci U S A, 110: 16175-16180.
          doi: 10.1073/pnas.1310432110

      7. Nguyen HP, Doan HQ, Brunell DJ, et al. 2014. Viral Immunol, 27: 556-558.
          doi: 10.1089/vim.2014.0081

      8. Saha B, Prasanna SJ, Chandrasekar B, et al. 2010. Cytokine, 50: 1-14.
          doi: 10.1016/j.cyto.2009.11.021

      9. Scheffner M, Huibregtse JM, Vierstra RD, et al. 1993. Cell, 75: 495-505.
          doi: 10.1016/0092-8674(93)90384-3

      10. Sigal LH. 2012. J Clin Rheumatol, 18: 83-88.
          doi: 10.1097/RHU.0b013e318247bc64

      11. Tatti S, Stockfleth E, Beutner KR, et al. 2010. Br J Dermatol, 162: 176-184.
          doi: 10.1111/bjd.2009.162.issue-1

      12. Tyring SK. 2012. J Clin Aesthet Dermatol, 5: 19-26.

      13. Wang ZM, Gao W, Wang H, et al. 2014. Cell Physiol Biochem, 33: 1349-58.
          doi: 10.1159/000358702

      14. Yu D, Jing T, Liu B, et al. 1998. Molec Cell, 2: 581-591.
          doi: 10.1016/S1097-2765(00)80157-4

      15. Yusuf-Makagiansar H, Anderson ME, Yakovleva TV, et al. 2002. Med Res Rev, 22: 146-167.
          doi: 10.1002/(ISSN)1098-1128

    • 加载中

    Tables(1)

    PDF

    Article Metrics

    Article views(5277) PDF downloads(23) Cited by()

    Related
    Proportional views

      Cellular signaling in sinecatechins-treated external genital and perianal warts: unraveling the mechanism of action of a botanical therapy

        Corresponding author: Stephen K Tyring, styring@ccstexas.com
      • 1. Department of Dermatology, Baylor College of Medicine, Houston 77004, USA
      • 2. Department of Dermatology, University of Texas Houston Health Science Center, Houston 77004, USA
      • 3. Center for Clinical Studies, Houston 77004, USA
      • Published Date: 25 March 2015

      Abstract: Taken together with our previous report, current results provide cursory evidence that the sinecatechins’ mechanism of action likely entails some degree of modulation of inflammatory and apoptotic processes, in particular, the NF-κB-pathway. It is possible that sinecatechins also upregulate the host immune response, since the only gene to be significantly upregulated in VR is the pro-lymphocytic IL2; however, further studies are needed to examine the exact pattern of immune regulation. Moreover, since no DEGs were identified in VNR in the prior report, the present study provides putative insight into the expression patterns of patients who are not responsive to sinecatechins.

        HTML