Citation: Flavia Adriana Zanetti, Romina Cardona, Carlos Rodolfo Federico, Silvina Chimeno-Zoth, Gabriela Calamante. Recombinant canarypox virus expressing the VP2 protein of infectious bursal disease virus induces protection in vaccinated SPF chickens .VIROLOGICA SINICA, 2016, 31(3) : 266-269.  http://dx.doi.org/10.1007/s12250-015-3680-6

Recombinant canarypox virus expressing the VP2 protein of infectious bursal disease virus induces protection in vaccinated SPF chickens

Protection against IBDV by CN048-VP2 vector

cstr: 32224.14.s12250-015-3680-6
  • Corresponding author: Gabriela Calamante, calamante.gabriela@inta.gob.ar, ORCID: 0000-0003-3968-190X
  • Published Date: 18 March 2016
    Available online: 01 April 2016
  • Infectious bursal disease virus (IBDV) causes infectious bursal disease, a highly contagious immunosuppressive disease that affects young chickens and causes economic losses in the poultry industry worldwide. IBDV replicates mainly in actively dividing B lymphocytes within the bursa of Fabricius (BF), leading to immunosuppression in affected flocks (Mahgoub et al., 2012). Viral protein 2 (VP2), the only structural component of the IBDV icosahedral capsid, is the major antigen responsible for inducing protective immunity in the host (Mahgoub et al., 2012).

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    1. Bayliss CD, Peters RW, Cook JK, et al. 1991. Arch Virol, 120: 193–205.
        doi: 10.1007/BF01310475

    2. Bublot M, Manvell RJ, Shell W, et al. 2010. Avian Dis, 54: 257–261.
        doi: 10.1637/8774-033109-ResNote.1

    3. Carballeda JM, Chimeno-Zoth S, Gómez E, et al. 2011. Immunobiology, 216: 1028–1033.
        doi: 10.1016/j.imbio.2011.03.003

    4. Darteil R, Bublot M, Laplace E, et al. 1995. Virology, 211:481–490.
        doi: 10.1006/viro.1995.1430

    5. Gómez E, Lucero MS, Chimeno-Zoth S, et al. 2013. Vaccine, 31: 2623–2627.
        doi: 10.1016/j.vaccine.2013.03.064

    6. Mahgoub HA, Bailey M, Kaiser P, et al. 2012. Arch Virol, 157: 2047–2057.
        doi: 10.1007/s00705-012-1377-9

    7. Müller H, Islam MR, Raue R. 2003. Vet Microbiol, 97: 153–165.
        doi: 10.1016/j.vetmic.2003.08.005

    8. Reed L, Muench H. 1938. Am J Hygiene, 2: 493–497.

    9. Rocha CD, Caetano BC, Machado AV, et al. 2004. Int Microbiol, 72: 83–94.

    10. Shaw I, Davison TF. 2000. Vaccine, 18: 3230–3241.
        doi: 10.1016/S0264-410X(00)00133-X

    11. Weli SC, Tryland M. 2011. Virol J, 8: 49.
        doi: 10.1186/1743-422X-8-49

    12. Zanetti FA, Conte Grand MD, Mitarotonda RC, et al. 2014. Braz J Microbiol, 45: 231–234.
        doi: 10.1590/S1517-83822014000100032

    13. Zanetti FA, Del Médico-Zajac MP, Taboga AO, et al. 2012. J Vet Sci, 13: 199–201.
        doi: 10.4142/jvs.2012.13.2.199

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    Recombinant canarypox virus expressing the VP2 protein of infectious bursal disease virus induces protection in vaccinated SPF chickens

      Corresponding author: Gabriela Calamante, calamante.gabriela@inta.gob.ar
    • 1. Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Rivadavia 1917 (C1033AAJ), Ciudad Autónoma de Buenos Aires, Argentina
    • 2. Instituto de Biotecnología, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, Instituto Nacional de Tecnología Agropecuaria (INTA), Buenos Aires, Argentina

    Abstract: Infectious bursal disease virus (IBDV) causes infectious bursal disease, a highly contagious immunosuppressive disease that affects young chickens and causes economic losses in the poultry industry worldwide. IBDV replicates mainly in actively dividing B lymphocytes within the bursa of Fabricius (BF), leading to immunosuppression in affected flocks (Mahgoub et al., 2012). Viral protein 2 (VP2), the only structural component of the IBDV icosahedral capsid, is the major antigen responsible for inducing protective immunity in the host (Mahgoub et al., 2012).