Serving the Society Since 1986
Advanced Search
Volume 32 Issue 6
December 2017
    Citation: Na Zhang, Youyang Ke, Leiliang Zhang. Interplay between hepatitis C virus and ARF4 .VIROLOGICA SINICA, 2017, 32(6) : 533-536.  http://dx.doi.org/10.1007/s12250-017-4000-0
    shu

    Interplay between hepatitis C virus and ARF4

    Interplay between HCV and ARF4

    • 1.

      MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100176, China

    • 2.

      Department of Emergency, 171st Hospital of PLA, Jiujiang 332000, China

    • Corresponding author: Youyang Ke, keyouyang001@163.com, ORCID: 0000-0002-3458-496X
      Leiliang Zhang, armzhang@hotmail.com, ORCID: 0000-0002-7015-9661
    • Received Date: 14 April 2017
      Accepted Date: 17 July 2017
      Published Date: 18 August 2017
      Available online: 01 December 2017
    • In summary, we show here that HCV infection is associated with an upregulation of ARF4, which promotes HCV replication. Upon HCV infection, CREB3 was redistributed to nucleus and activated ARF4 transcription. Our studies demonstrate a host factor ARF4 upregulated in HCV replication, which may provide new therapeutic targets for antiviral therapy.
    • 加载中

      1. Farhat R, Seron K, Ferlin J, et al. 2016. Cell Microbiol, 18: 1121–1133.
          doi: 10.1111/cmi.v18.8

      2. Gillingham AK, Munro S. 2007. Annu Rev Cell Dev Biol, 23: 579–611.
          doi: 10.1146/annurev.cellbio.23.090506.123209

      3. Jang SY, Jang SW, Ko J. 2012. Cancer Lett, 314: 185–197.
          doi: 10.1016/j.canlet.2011.09.028

      4. Jin DY, Wang HL, Zhou Y, et al. 2000. EMBO J, 19: 729–740.
          doi: 10.1093/emboj/19.4.729

      5. Li H, Yang X, Yang G, et al. 2014. J Virol, 88: 5956–5966.
          doi: 10.1128/JVI.03738-13

      6. Matto M, Sklan EH, David N, et al. 2011. J Virol, 85: 946–956.
          doi: 10.1128/JVI.00753-10

      7. Raggo C, Rapin N, Stirling J, et al. 2002. Mol Cell Biol, 22: 5639–5649.
          doi: 10.1128/MCB.22.16.5639-5649.2002

      8. Reiling JH, Olive AJ, Sanyal S, et al. 2013. Nat Cell Biol, 15: 1473–1485.
          doi: 10.1038/ncb2865

      9. Tai AW, Benita Y, Peng LF, et al. 2009. Cell Host Microbe, 5: 298–307.
          doi: 10.1016/j.chom.2009.02.001

      10. Zhang L, Hong Z, Lin W, et al. 2012. PLoS One, 7: e32135.
          doi: 10.1371/journal.pone.0032135

      11. Zhang N, Yin P, Zhou L, et al. 2016. Biochem Biophys Res Commun, 475: 31–36.
          doi: 10.1016/j.bbrc.2016.05.024

      12. Zhou LY, Zhang LL. 2016. World J Gastroenterol, 22: 1477–1486.
          doi: 10.3748/wjg.v22.i4.1477

    • 加载中

    Figures(1)

    PDF

    Article Metrics

    Article views(6151) PDF downloads(22) Cited by()

    Related
    Proportional views

      Interplay between hepatitis C virus and ARF4

        Corresponding author: Youyang Ke, keyouyang001@163.com
        Corresponding author: Leiliang Zhang, armzhang@hotmail.com
      • 1. MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100176, China
      • 2. Department of Emergency, 171st Hospital of PLA, Jiujiang 332000, China
      • Received Date: 14 April 2017
      • Accepted Date: 17 July 2017
      • Published Date: 18 August 2017

      Abstract: In summary, we show here that HCV infection is associated with an upregulation of ARF4, which promotes HCV replication. Upon HCV infection, CREB3 was redistributed to nucleus and activated ARF4 transcription. Our studies demonstrate a host factor ARF4 upregulated in HCV replication, which may provide new therapeutic targets for antiviral therapy.

        HTML