-
Abdel-Rahman MA, Quintero-Hernandez V, Possani LD (2013) Venom proteomic and venomous glands transcriptomic analysis of the Egyptian scorpion Scorpio maurus palmatus (Arachnida: Scorpionidae). Toxicon 74:193-207
doi: 10.1016/j.toxicon.2013.08.064
-
Alesha Grant SS, Tripathi Shashank, Balasubramaniam Vinod, Lisa Miorin MS, Schwarz Megan C, Sánchez-Seco Mari Paz, Matthew J, Evans SM, García-Sastre A (2016) Zika virus impairs growth in human neurospheres and brain organoids. Cell Host Microbe 19:882-890
doi: 10.1016/j.chom.2016.05.009
-
Biragyn A, Ruffini PA, Leifer CA, Klyushnenkova E, Shakhov A, Chertov O, Shirakawa AK, Farber JM, Segal DM, Oppenheim JJ, Kwak LW (2002) Toll-like receptor 4-dependent activation of dendritic cells by β-Denfensin 2. Science 298:1025-1029
doi: 10.1126/science.1075565
-
Bogoch II, Brady OJ, Kraemer MU, German M, Creatore MI, Brent S, Watts AG, Hay SI, Kulkarni MA, Brownstein JS, Khan K (2016) Potential for Zika virus introduction and transmission in resource-limited countries in Africa and the Asia-Pacific region: a modelling study. Lancet Infect Dis 16:1237-1245
doi: 10.1016/S1473-3099(16)30270-5
-
Carballar-Lejarazu R, Rodriguez MH, Hernandez-Hernandez FC, Ramos-Castaneda J, Possani LD, Zurita-Ortega M, Reynaud-Garza E, Hernandez-Rivas R, Loukeris T, Lycett G, Lanz-Mendoza H (2008) Recombinant scorpine: a multifunctional antimicrobial peptide with activity against different pathogens. Cell Mol Life Sci 65:3081-3092
doi: 10.1007/s00018-008-8250-8
-
Chan JF, Choi GK (2016) Zika fever and congenital Zika syndrome: an unexpected emerging arboviral disease. J Infect Dis 220:449
-
Cui X, Wu Y, Fan D, Gao N, Ming Y, Wang P, An J (2018) Peptides P4 and P7 derived from E protein inhibit entry of dengue virus serotype 2 via interacting with β3 integrin. Antivir Res 155:20-27
doi: 10.1016/j.antiviral.2018.04.018
-
Dai JF, Pan W, Wang PH (2011) ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitro. Virol J 8:486-492
doi: 10.1186/1743-422X-8-486
-
Easton DM, Nijnik A, Mayer ML, Hancock RE (2009) Potential of immunomodulatory host defense peptides as novel anti-infectives. Trends Biotechnol 27:582-590
doi: 10.1016/j.tibtech.2009.07.004
-
Halstead SB (2007) Dengue. Lancet 370:1644-1652
doi: 10.1016/S0140-6736(07)61687-0
-
Hancock RE, Finlay BB (2004) Can innate immunity be enhanced to treat microbial infections. Nat Rev Microbiol 2:497-504
doi: 10.1038/nrmicro908
-
Heymann DL, Hodgson A, Sall AA, Freedman DO, Staples JE, Althabe F, Baruah K, Mahmud G, Kandun N, Vasconcelos FC, Bino S, Menon KU (2016) Zika virus and microcephaly: why is this situation a PHEIC? Lancet 387:719-721
doi: 10.1016/S0140-6736(16)00320-2
-
Hilchie AL, Wuerth K, Hancock RE (2013) Immune modulation by multifaceted cationic host defense (antimicrobial) peptides. Nat Chem Biol 9:761-768
doi: 10.1038/nchembio.1393
-
Hishiki T, Han QE, Arimoto K, Shimotohno K, Igarashi T, Vasudevan SG, Suzuki Y, Yamamoto N (2014) Interferon-mediated ISG15 conjugation restricts dengue virus 2 replication. Biochem Biophys Res Commun 448:95-100
doi: 10.1016/j.bbrc.2014.04.081
-
Holthausen DJ, Lee SH, Kumar VT, Bouvier NM, Krammer F, Ellebedy AH, Wrammert J, Lowen AC, George S, Pillai MR, Jacob J (2017) An amphibian host defense peptide is virucidal for human H1 hemagglutinin-bearing influenza viruses. Immunity 46:587-595
doi: 10.1016/j.immuni.2017.03.018
-
Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z (2013) Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. Biomaterials 34:3511-3522
doi: 10.1016/j.biomaterials.2013.01.075
-
Hong W, Li T, Song Y, Zhang R, Zeng Z, Han S, Zhang X, Wu Y, Li W, Cao Z (2014) Inhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1. Antivir Res 102:1-10
-
Jiang SB, Lin K, Strick N, Neurath AR (1993) HIV-1 inhibition by a peptide. Nature 365:113
-
Jones M, Davidson A, Hibbert L, Gruenwald P, Schlaak J, Ball S, Foster GR, Jacobs M (2005) Dengue virus inhibits alpha interferon signaling by reducing STAT2 expression. J Virol 79:5414-5420
doi: 10.1128/JVI.79.9.5414-5420.2005
-
Lande R, Gregorio J, Facchinetti V, Chatterjee B, Wang YH, Homey B, Cao W, Wang YH, Su B, Nestle FO, Zal T, Mellman I, Schroder JM, Liu YJ, Gilliet M (2007) Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 449:564-569
doi: 10.1038/nature06116
-
Lin RJ, Yu HP, Chang BL, Tang WC, Liao CL, Lin YL (2009) Distinct antiviral roles for human 2′, 5′-oligoadenylate synthetase family members against dengue virus infection. J Immunol 183:8035-8043
doi: 10.4049/jimmunol.0902728
-
Loo YM, Gale M Jr (2011) Immune signaling by RIG-I-like receptors. Immunity 34:680-692
doi: 10.1016/j.immuni.2011.05.003
-
McMichael AJ, Woodruff RE, Hales S (2006) Climate change and human health: present and future risks. Lancet 367:859-869
doi: 10.1016/S0140-6736(06)68079-3
-
Morrison J, Laurent-Rolle M, Maestre AM, Rajsbaum R, Pisanelli G, Simon V, Mulder LC, Fernandez-Sesma A, Garcia-Sastre A (2013) Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type Ⅰ interferon signaling. PLoS Pathog 9:e1003265
doi: 10.1371/journal.ppat.1003265
-
Muller U, Steinhoff U, Reis LF, Hemmi S, Paviovic J, Zinkernagel RM, Aguet M (1994) Functional role of type Ⅰ and type Ⅱ Interferons in antiviral defense. Science 264:1918-1921
doi: 10.1126/science.8009221
-
Pichlmair A, Reis e Sousa C (2007) Innate recognition of viruses. Immunity 27:370-383
doi: 10.1016/j.immuni.2007.08.012
-
Reddy KV, Yedery RD, Aranha C (2004) Antimicrobial peptides: premises and promises international. J Antimicrob Agents 24:536-547
doi: 10.1016/j.ijantimicag.2004.09.005
-
Renaud Conde FZ, Rodriguez Mario H, Possani Lourival D (2000) Scorpine, an anti-malaria and anti-bacterial agent purified from scorpion venom. FEBS Lett 471:165-168
doi: 10.1016/S0014-5793(00)01384-3
-
Sainz B, Halford WP (2002) Alpha/beta interferon and gamma interferon synergize to inhibit the replication of herpes simplex virus type 1. J Virol 76:11541-11550
doi: 10.1128/JVI.76.22.11541-11550.2002
-
Schmidt AG, Yang PL, Harrison SC (2010) Peptide inhibitors of dengue-virus entry target a late-stage fusion intermediate. PLoS Pathog 6:e1000851
doi: 10.1371/journal.ppat.1000851
-
Schoggins JW, Wilson SJ, Panis M, Murphy MY, Jones CT, Bieniasz P, Rice CM (2011) A diverse range of gene products are effectors of the type Ⅰ interferon antiviral response. Nature 472:481-485
doi: 10.1038/nature09907
-
Scott MG, Dullaghan E, Mookherjee N, Glavas N, Waldbrook M, Thompson A, Wang A, Lee K, Doria S, Hamill P, Yu JJ, Li Y, Donini O, Guarna MM, Finlay BB, North JR, Hancock RE (2007) An anti-infective peptide that selectively modulates the innate immune response. Nat Biotechnol 25:465-472
doi: 10.1038/nbt1288
-
Screaton G, Mongkolsapaya J, Yacoub S, Roberts C (2015) New insights into the immunopathology and control of dengue virus infection. Nat Rev Immunol 15:745-759
doi: 10.1038/nri3916
-
Seth RB, Sun L, Chen ZJ (2006) Antiviral innate immunity pathways. Cell Res 16:141-147
doi: 10.1038/sj.cr.7310019
-
Shepard DS, Undurraga EA, Halasa YA, Stanaway JD (2016) The global economic burden of dengue: a systematic analysis. Lancet Infect Dis 16:935-941
doi: 10.1016/S1473-3099(16)00146-8
-
Theofilopoulos AN, Baccala R, Beutler B, Kono DH (2005) Type Ⅰ interferons (alpha/beta) in immunity and autoimmunity. Annu Rev Immunol 23:307-336
doi: 10.1146/annurev.immunol.23.021704.115843
-
Uawonggul N, Sukprasert S, Incamnoi P, Patramanon R, Thammasirirak S, Preecharram S, Bunyatratchata W, Kuaprasert B, Daduang J, Daduang S (2014) Bacterial overexpression ofrecombinant heteroscorpine-1 (rHS-1), a toxin from Heterometrus laoticus scorpion venom: trends forantibacterial application and antivenom production. Biochem Genet 52:459-473
doi: 10.1007/s10528-014-9660-y
-
Ubol S, Masrinoul P, Chaijaruwanich J, Kalayanarooj S, Charoensirisuthikul T, Kasisith J (2008) Differences in global gene expression in peripheral blood mononuclear cells indicate a significant role of the innate responses in progression of dengue fever but not dengue hemorrhagic fever. J Infect Dis 197:1459-1467
doi: 10.1086/589588
-
Yasin B, Wang W, Pang M, Cheshenko N, Hong T, Waring AJ, Herold BC, Wagar EA, Lehrer RI (2004) θ Defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry. J Virol 78:5147-5156
doi: 10.1128/JVI.78.10.5147-5156.2004
-
Yu JS, Tseng CK, Lin CK, Hsu YC, Wu YH, Hsieh CL, Lee JC (2017a) Celastrol inhibits dengue virus replication via up-regulating type Ⅰ interferon and downstream interferon-stimulated responses. Antivir Res 137:49-57
doi: 10.1016/j.antiviral.2016.11.010
-
Yu Y, Deng Y, Zou P, Wang Q, Dai Y, Yu F, Du L, Zhang N, Tian M, Hao J, Meng Y, Li Y, Zhou X, Chan JF, Yuen KY, Qin CF, Jiang SB, Lu L (2017b) A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses. Nat Commun 8:15672
doi: 10.1038/ncomms15672
-
Zeng Z, Zhang R, Hong W, Cheng Y, Wang H, Lang Y, Ji Z, Wu Y, Li W, Xie Y, Cao Z (2018) Histidine-rich modification of a scorpion-derived peptide improves bioavailability and inhibitory activity against HSV-1. Theranostics 8:199-211
doi: 10.7150/thno.21425
-
Zhao Z, Hong W, Zeng Z, Wu Y, Hu K, Tian X, Li W, Cao Z (2012) Mucroporin-M1 inhibits hepatitis B virus replication by activating the mitogen-activated protein kinase (MAPK) pathway and down-regulating HNF4alpha in vitro and in vivo. J Biol Chem 287:30181-30190
doi: 10.1074/jbc.M112.370312