Citation: Chun-yu YIN, Hong-zhou LU, Wei-ming JIANG, Maria Pia De Pasquale, Yue-kai HU, Xiao-zhang PAN, Xin-hua WENG, Richard T. D'Aquila, Yi-Wei TANG. Differences in Variation of Human Immunodeficiency Virus Type 1 Sequences from Henan and Shanghai Regions of China .VIROLOGICA SINICA, 2007, 22(3) : 212-217.

Differences in Variation of Human Immunodeficiency Virus Type 1 Sequences from Henan and Shanghai Regions of China

  • Corresponding author: Hong-zhou LU, Luhong zhou66@hotmail.com
    Yi-Wei TANG, yiwei.tang@vanderbilt.edu
  • Received Date: 03 November 2006
    Accepted Date: 27 December 2006
    Available online: 01 June 2007

    Fund Project: R.T.D R01 AI 29193Start Fund of Ministry of Education of China for Hong-zhou LUThe Vanderbilt-Meharry Center for AIDS Research P30 AI 54999Start Fund of Ministry of Education of China 2004BA719A10

  • Illegally paid blood donation was a risk factor for HIV acquisition exclusively in Henan and Hubei Provinces of China, and not in Shanghai. Nucleotide sequences in the gag and env genes of HIV-1 were compared between isolates from Henan and Shanghai regions of China to test whether an expected higher degree of a common source of infections from this unique blood donation transmission risk would be evident as decreased variation among Henan isolates in an exploratory cross-sectional analysis. Among 38 isolates studied, 23 of 23 (100%) from Henan and 8 of 15 (54%) from Shanghai were subtype B. In addition, fewer sequence differences were found in gp41 of subtype B isolates from Henan than from Shanghai isolates. Further studies with additional controls are therefore warranted to confirm the role of the degree of a common source of infections in differences in HIV variation across populations.

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    Differences in Variation of Human Immunodeficiency Virus Type 1 Sequences from Henan and Shanghai Regions of China

      Corresponding author: Hong-zhou LU, Luhong zhou66@hotmail.com
      Corresponding author: Yi-Wei TANG, yiwei.tang@vanderbilt.edu
    • 1. Department of Infectious Diseases, Fudan University Huashan Hospital, Shanghai 200040, China
    • 2. Department of Infectious Diseases, the Sixth Peopleos Hospital, Hangzhou 310014, China
    • 3. Division of Infectious Diseases, Department of Medicine; Tennessee 37232, USA
    • 4. Departments of Pathology; Tennessee 37232, USA
    • 5. Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Fund Project:  R.T.D R01 AI 29193Start Fund of Ministry of Education of China for Hong-zhou LUThe Vanderbilt-Meharry Center for AIDS Research P30 AI 54999Start Fund of Ministry of Education of China 2004BA719A10

    Abstract: Illegally paid blood donation was a risk factor for HIV acquisition exclusively in Henan and Hubei Provinces of China, and not in Shanghai. Nucleotide sequences in the gag and env genes of HIV-1 were compared between isolates from Henan and Shanghai regions of China to test whether an expected higher degree of a common source of infections from this unique blood donation transmission risk would be evident as decreased variation among Henan isolates in an exploratory cross-sectional analysis. Among 38 isolates studied, 23 of 23 (100%) from Henan and 8 of 15 (54%) from Shanghai were subtype B. In addition, fewer sequence differences were found in gp41 of subtype B isolates from Henan than from Shanghai isolates. Further studies with additional controls are therefore warranted to confirm the role of the degree of a common source of infections in differences in HIV variation across populations.