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Volume 22 Issue 3
June 2007
    Citation: Lin-ding WANG. Pathogenesis and Associated Diseases of Kaposi's Sarcoma-associated Herpesvirus .VIROLOGICA SINICA, 2007, 22(3) : 248-255.
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    Pathogenesis and Associated Diseases of Kaposi's Sarcoma-associated Herpesvirus

    • State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China

    • Corresponding author: Lin-ding WANG, wangld@wh.iov.cn
    • Received Date: 21 November 2006
      Accepted Date: 02 February 2007
      Available online: 01 June 2007

      Fund Project:

    • Kaposi’s sarcoma-associated herpesvirus (KSHV) is the primary etiological agent of Kaposi’s sarcoma, primary effusion lymphoma and muticentric Castleman’s disease. In common with the other herpesviruses, KSHV exhibits both latent and lytic life cycles, both of which are characterized by distinct gene expression profiles and programs. KSHV encodes proteins which play essential roles in the inhibition of host adaptive and innate immunity, the inhibition of apoptosis, and the regulation of the cell cycle. KSHV also encodes several proteins which have transforming and intrcellular signalling activity.
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      Pathogenesis and Associated Diseases of Kaposi's Sarcoma-associated Herpesvirus

        Corresponding author: Lin-ding WANG, wangld@wh.iov.cn
      • State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
      • Received Date: 21 November 2006
      • Accepted Date: 02 February 2007
      Fund Project: 

      Abstract: Kaposi’s sarcoma-associated herpesvirus (KSHV) is the primary etiological agent of Kaposi’s sarcoma, primary effusion lymphoma and muticentric Castleman’s disease. In common with the other herpesviruses, KSHV exhibits both latent and lytic life cycles, both of which are characterized by distinct gene expression profiles and programs. KSHV encodes proteins which play essential roles in the inhibition of host adaptive and innate immunity, the inhibition of apoptosis, and the regulation of the cell cycle. KSHV also encodes several proteins which have transforming and intrcellular signalling activity.

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