Citation: WU Ting, HUANG Hai. The Inhibitory Effects of Enduracidin on Hepatitis B Virus in vitro .VIROLOGICA SINICA, 1998, 13(1) : 45.

The Inhibitory Effects of Enduracidin on Hepatitis B Virus in vitro

  • Available online: 05 March 1998
  • Enduracidin was studied for its ability to inhibit Hepatitis B Virus DNA, HBsAg and HBeAg secreted by a HBV transfected cell line (HepG 2.2.2.15). The result showed that IC 50 (the drug concentration that inhibits HBsAg or HBeAg secretion by 50%)was 27μg/mL and 34μg/mL respectively, theraputic index (TI) was 5.9 and 4.6. Enduracidin at the concentration of 50μg/mL inhibited 56.8% of the production of free HBV DNA in the Cells.

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    The Inhibitory Effects of Enduracidin on Hepatitis B Virus in vitro

    • 1. School of Pharmacy,Shanghai Medical Universlty,Shanghai 200032

    Abstract: Enduracidin was studied for its ability to inhibit Hepatitis B Virus DNA, HBsAg and HBeAg secreted by a HBV transfected cell line (HepG 2.2.2.15). The result showed that IC 50 (the drug concentration that inhibits HBsAg or HBeAg secretion by 50%)was 27μg/mL and 34μg/mL respectively, theraputic index (TI) was 5.9 and 4.6. Enduracidin at the concentration of 50μg/mL inhibited 56.8% of the production of free HBV DNA in the Cells.

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