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Volume 23 Issue 3
June 2008
    Citation: Chun-ling FAN, Jing-hua ZHOU, Cheng-yi HU. Expression of Human Papillomavirus in Mammary Carcinoma and its Possible Mechanism in Carcinogenesis .VIROLOGICA SINICA, 2008, 23(3) : 226-231.  http://dx.doi.org/10.1007/s12250-008-2914-2
    shu

    Expression of Human Papillomavirus in Mammary Carcinoma and its Possible Mechanism in Carcinogenesis

    • 1.

      Heilongjiang August-first Land-Reclamation University, Daqing 163319, China

    • 2.

      Heilongjiang Chinese Medical University, Harbin 150040, China

    • 3.

      The 4th Hospital of Harbin Medical University Harbin 150010, China

    • Corresponding author: Cheng-yi HU, fanchunling2006@yahoo.com.cn
    • Received Date: 13 September 2007
      Accepted Date: 04 May 2008
      Available online: 01 June 2008
    • To explore the role of Human papillomavirus (HPV) in mammary carcinogenesis, the expression of the HPV-16, iNOS , P53 and hTERT proteins in breast carcinomas and their relationships were investigated. 52 samples of breast cancer and 16 samples of benign breast tumors were assayed using the immunohistochemical SP method for detection of protein expression levels. The expression of HPV-16, iNOS, P53 and hTERT proteins in a mammary carcinoma was 44.2%, 57.7%, 63.5% and 59.6% respectively, which was significantly greater than the corresponding levels in the benign group. The expression of iNOS, P53 and hTERT was correlated with the presence of an HPV-16 infection in a mammary carcinoma（P＜0.05）. The connection between these events might also involve the iNOS, mutated type P53 and the hTERT protein.
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      2. Ambs S, Merriam W G, Bennett W P, et al. 1998. Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression. Cancer Res, 58: 334-341.

      3. Brennan P A, Controy B, Spedding A V, et al. 2000. Expression of inducible nitric oxide synthase and P53 in oral epithelial dyplasia. Oral Surg Oral Med Oral Radiol Endon, 90 (5): 624-629.
          doi: 10.1067/moe.2000.108800

      4. Ellie E, Loiseau H, Lafond F, et al. 1995. Differential expression of inducible nitric oxide synthase mRNA in human brain tumours. Neuroreport, 7: 294-296.
          doi: 10.1097/00001756-199512000-00070

      5. Erden E, Bulut A S, Sak S D, et al. 2005. Significance of inducible nitric oxide synthase expression in benign and malignant breast epithelium:an immunohisto chemical study of 151 cases. Virchow Arch, 447 (1): 24-30.
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      6. Felley-Bosco E. 1998. Role of nitric oxide in genotoxicity: implication for carcinogenesis. Cancer Metastasis Rev, 17: 25-37.
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      7. Gallo O, Masini E, Morbidelli L, et al. 1998. Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer. J Natl Cancer Inst, 90: 587-596.
          doi: 10.1093/jnci/90.8.587

      8. Geller D A, Billiar T R. 1998.Molecular biology of nitric oxide synthases. Cancer Metastasis Rev, 17: 7-23.
          doi: 10.1023/A:1005940202801

      9. James F, Crish, Frederic Bone, et al. 2000.Suprabasal expression of the human papillomavirus type 16 oncopro-teins in mouse epidermis alters expression of cell cycle regulatory proteins. Carcinogenesis, 21 (5): 1031-1037.
          doi: 10.1093/carcin/21.5.1031

      10. Lala P K, Orucevic A. 1998. Role of nitric oxide in tumor progression: Lessons from experimental tumors. Cancer Metastasis Rev, 17: 91-106
          doi: 10.1023/A:1005960822365

      11. Liu X, H Yuan, B Fu, et al. 2005. The E6AP ubiquitin ligase is required for transactivation of the hTERT promoter by the human papillomavirus E6 oncoprotein. J Biol Chem, 280: 10807-10816.
          doi: 10.1074/jbc.M410343200

      12. Liu L. 2006. Expression of P53 and iNOS in tumor of ovary and their dependability. J Medical Res, 35 (7): 71-73.(in Chinese)

      13. Meng W, Hou G, JIA Y S, et al. 2004.Ralationship between iducible nitric oxide synthase and clinicopatho-logical parameters in breast cancer and its siginificance. J Treat Prev, 11 (8): 808-810.(in Chinese)

      14. Nathan C, Xie Q. 1994. Regulation of biosynthesis of nitric oxide. J Biol Chem, 269: 13725-13728.

      15. Reveneau S, Amouldb L, Jolimoy G, et al. 1999. Nitric oxide synthase in human breast cancer is associated with tumor grade, proliferation rate, and expression of proges-terone receptors. Lab Invest, 79 (10): 1215-1225.

      16. Thomsen L L, Miles D W, Happerfield L, et al. 1995. Nitric oxide synthase activity in human breast cancer. Br J Cancer, 72:41-44.
          doi: 10.1038/bjc.1995.274

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      Expression of Human Papillomavirus in Mammary Carcinoma and its Possible Mechanism in Carcinogenesis

        Corresponding author: Cheng-yi HU, fanchunling2006@yahoo.com.cn
      • 1. Heilongjiang August-first Land-Reclamation University, Daqing 163319, China
      • 2. Heilongjiang Chinese Medical University, Harbin 150040, China
      • 3. The 4th Hospital of Harbin Medical University Harbin 150010, China
      • Received Date: 13 September 2007
      • Accepted Date: 04 May 2008

      Abstract: To explore the role of Human papillomavirus (HPV) in mammary carcinogenesis, the expression of the HPV-16, iNOS , P53 and hTERT proteins in breast carcinomas and their relationships were investigated. 52 samples of breast cancer and 16 samples of benign breast tumors were assayed using the immunohistochemical SP method for detection of protein expression levels. The expression of HPV-16, iNOS, P53 and hTERT proteins in a mammary carcinoma was 44.2%, 57.7%, 63.5% and 59.6% respectively, which was significantly greater than the corresponding levels in the benign group. The expression of iNOS, P53 and hTERT was correlated with the presence of an HPV-16 infection in a mammary carcinoma（P＜0.05）. The connection between these events might also involve the iNOS, mutated type P53 and the hTERT protein.

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