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Citation: Chun-ling FAN, Jing-hua ZHOU, Cheng-yi HU. Expression of Human Papillomavirus in Mammary Carcinoma and its Possible Mechanism in Carcinogenesis [J].VIROLOGICA SINICA, 2008, 23(3) : 226-231.  http://dx.doi.org/10.1007/s12250-008-2914-2

Expression of Human Papillomavirus in Mammary Carcinoma and its Possible Mechanism in Carcinogenesis

  • Corresponding author: Cheng-yi HU, fanchunling2006@yahoo.com.cn
  • Received Date: 13 September 2007
    Accepted Date: 04 May 2008
    Available online: 01 June 2008
  • To explore the role of Human papillomavirus (HPV) in mammary carcinogenesis, the expression of the HPV-16, iNOS , P53 and hTERT proteins in breast carcinomas and their relationships were investigated. 52 samples of breast cancer and 16 samples of benign breast tumors were assayed using the immunohistochemical SP method for detection of protein expression levels. The expression of HPV-16, iNOS, P53 and hTERT proteins in a mammary carcinoma was 44.2%, 57.7%, 63.5% and 59.6% respectively, which was significantly greater than the corresponding levels in the benign group. The expression of iNOS, P53 and hTERT was correlated with the presence of an HPV-16 infection in a mammary carcinoma(P<0.05). The connection between these events might also involve the iNOS, mutated type P53 and the hTERT protein.

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    Expression of Human Papillomavirus in Mammary Carcinoma and its Possible Mechanism in Carcinogenesis

      Corresponding author: Cheng-yi HU, fanchunling2006@yahoo.com.cn
    • 1. Heilongjiang August-first Land-Reclamation University, Daqing 163319, China
    • 2. Heilongjiang Chinese Medical University, Harbin 150040, China
    • 3. The 4th Hospital of Harbin Medical University Harbin 150010, China

    Abstract: To explore the role of Human papillomavirus (HPV) in mammary carcinogenesis, the expression of the HPV-16, iNOS , P53 and hTERT proteins in breast carcinomas and their relationships were investigated. 52 samples of breast cancer and 16 samples of benign breast tumors were assayed using the immunohistochemical SP method for detection of protein expression levels. The expression of HPV-16, iNOS, P53 and hTERT proteins in a mammary carcinoma was 44.2%, 57.7%, 63.5% and 59.6% respectively, which was significantly greater than the corresponding levels in the benign group. The expression of iNOS, P53 and hTERT was correlated with the presence of an HPV-16 infection in a mammary carcinoma(P<0.05). The connection between these events might also involve the iNOS, mutated type P53 and the hTERT protein.