Citation: Ina Schulte, E-juan ZHANG, Zhong-ji MENG, Rong-juan PEI, Mengji LU, Michael Roggendorf. Recent Advances in Research on Hepadnaviral Infection in the Woodchuck Model* .VIROLOGICA SINICA, 2008, 23(2) : 107-115.  http://dx.doi.org/10.1007/s12250-008-2941-z

Recent Advances in Research on Hepadnaviral Infection in the Woodchuck Model*

  • Corresponding author: Michael Roggendorf, Michael.roggendorf@uni-due.de
  • Received Date: 22 December 2007
    Accepted Date: 24 January 2008
    Available online: 01 April 2008

    Fund Project: Deutsche Forschungsgemeinschaft Lu 669/5-1Deutsche Forschungsgemeinschaft Lu669/2-1Deutsche Forschungsgemeinschaft GRK1045/1

  • The woodchuck model is an excellent animal model to study hepadnaviral infection. The new progresses in this model made possible to examine the T-cell mediated immune responses in acute and chronic hepadnaviral infection. Recently, a new assay for cytotoxic T-cells based on detection of CD107 was established for the woodchuck model. In addition, new immunotherapeutic approaches based on combination of potent antiviral treatment and DNA-protein vaccines were proven to be useful for treatment of chronic hepatitis B.

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    Recent Advances in Research on Hepadnaviral Infection in the Woodchuck Model*

      Corresponding author: Michael Roggendorf, Michael.roggendorf@uni-due.de
    • 1. Institute of Virology, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany
    • 2. Department of Microbiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
    • 3. State Key Lab of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, Chinas
    Fund Project:  Deutsche Forschungsgemeinschaft Lu 669/5-1Deutsche Forschungsgemeinschaft Lu669/2-1Deutsche Forschungsgemeinschaft GRK1045/1

    Abstract: The woodchuck model is an excellent animal model to study hepadnaviral infection. The new progresses in this model made possible to examine the T-cell mediated immune responses in acute and chronic hepadnaviral infection. Recently, a new assay for cytotoxic T-cells based on detection of CD107 was established for the woodchuck model. In addition, new immunotherapeutic approaches based on combination of potent antiviral treatment and DNA-protein vaccines were proven to be useful for treatment of chronic hepatitis B.