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Volume 23 Issue 6
December 2008
    Citation: Yan-chun CHE, Li JIANG, Qi-han LI. Molecular Modification of a HSV-1 Protein and Its Associated Gene Transcriptional Regulation .VIROLOGICA SINICA, 2008, 23(6) : 394-398.  http://dx.doi.org/10.1007/s12250-008-2994-z
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    Molecular Modification of a HSV-1 Protein and Its Associated Gene Transcriptional Regulation

    • Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 379 Jiao Ling Road, Kunming 650118, China

    • Corresponding author: Qi-han LI, Imbcams.LQ@gmail.com
    • Received Date: 08 August 2008
      Accepted Date: 17 September 2008
      Available online: 01 December 2008

      Fund Project: National Natural Science Foundation of China 30670094National Natural Science Foundation of China 30700028

    • The molecular modifications of Herpes Simplex Virus Type I （HSV-1） proteins represented by acetylation and phosphorylation are essential to its biological functions. The cellular chromatin-remodeling/ assembly is involved in HSV-1 associated gene transcriptional regulation in human cells harboring HSV-1 lytic or latent infections. Further investigation on these biological events would provide a better understanding of the mechanisms of HSV-1 viral gene transcriptional regulation
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      Molecular Modification of a HSV-1 Protein and Its Associated Gene Transcriptional Regulation

        Corresponding author: Qi-han LI, Imbcams.LQ@gmail.com
      • Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 379 Jiao Ling Road, Kunming 650118, China
      • Received Date: 08 August 2008
      • Accepted Date: 17 September 2008
      Fund Project:  National Natural Science Foundation of China 30670094National Natural Science Foundation of China 30700028

      Abstract: The molecular modifications of Herpes Simplex Virus Type I （HSV-1） proteins represented by acetylation and phosphorylation are essential to its biological functions. The cellular chromatin-remodeling/ assembly is involved in HSV-1 associated gene transcriptional regulation in human cells harboring HSV-1 lytic or latent infections. Further investigation on these biological events would provide a better understanding of the mechanisms of HSV-1 viral gene transcriptional regulation

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