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Volume 23 Issue 6
December 2008
    Citation: Yijie Ma, Dustin Verpooten, Bin He. Herpes Simplex Viruses and Induction of Interferon Responses .VIROLOGICA SINICA, 2008, 23(6) : 416-428.  http://dx.doi.org/10.1007/s12250-008-2999-7
    shu

    Herpes Simplex Viruses and Induction of Interferon Responses

    • Department of Microbiology and Immunology, College of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA

    • Corresponding author: Bin He, tshuo@uic.edu
    • Received Date: 01 September 2008
      Accepted Date: 03 September 2008
      Available online: 01 December 2008
    • Herpes simplex viruses (HSV) are human pathogens responsible for a variety of diseases, including localized mucocutaneous lesions, encephalitis, and disseminated diseases. HSV infection leads to rapid induction of innate immune responses. A critical part of this host response is the type I IFN system including the induction of type I IFNs, IFN-mediated signaling and amplification of IFN response. This provides the host with immediate countermeasure during acute infection to limit initial viral replication and to facilitate an appropriate adaptive immune response. However, HSV has devised multiple strategies to evade and interfere with innate immunity. This review will focus on the induction of type I IFN response by HSV during acute infection and current knowledge of mechanisms by which HSV interferes with this induction process.
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      Herpes Simplex Viruses and Induction of Interferon Responses

        Corresponding author: Bin He, tshuo@uic.edu
      • Department of Microbiology and Immunology, College of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA
      • Received Date: 01 September 2008
      • Accepted Date: 03 September 2008

      Abstract: Herpes simplex viruses (HSV) are human pathogens responsible for a variety of diseases, including localized mucocutaneous lesions, encephalitis, and disseminated diseases. HSV infection leads to rapid induction of innate immune responses. A critical part of this host response is the type I IFN system including the induction of type I IFNs, IFN-mediated signaling and amplification of IFN response. This provides the host with immediate countermeasure during acute infection to limit initial viral replication and to facilitate an appropriate adaptive immune response. However, HSV has devised multiple strategies to evade and interfere with innate immunity. This review will focus on the induction of type I IFN response by HSV during acute infection and current knowledge of mechanisms by which HSV interferes with this induction process.

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      INTRODUCTION