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Volume 29 Issue 1
February 2014
    Citation: Jia Liu, Anna Kosinska, Mengji Lu, Michael Roggendorf. New therapeutic vaccination strategies for the treatment of chronic hepatitis B .VIROLOGICA SINICA, 2014, 29(1) : 10-16.  http://dx.doi.org/10.1007/s12250-014-3410-5
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    New therapeutic vaccination strategies for the treatment of chronic hepatitis B

    • Institute for Virology, University Hospital of Essen, University of Duisburg-Essen, Virchowstraβe 179, 45122 Essen, Germany

    • Corresponding author: Michael Roggendorf, michael.roggendorf@uni-due.de
    • Received Date: 21 December 2013
      Accepted Date: 08 January 2014
      Published Date: 17 January 2014
      Available online: 01 February 2014
    • Chronic hepatitis B virus (CHB) is currently treated with either interferon-based or nucleot(s)ide-based antiviral therapies. However, treatment with pegylated interferon alpha results in a durable antiviral response in only about 30% patients and is associated with side effects. Most patients receiving nucleot(s)ide analogue treatment do not establish long-term, durable control of infection and have rebounding viremia after cessation of therapy. Thus, novel therapy strategies are necessary to achieve the induction of potent and durable antiviral immune responses of the patients which can maintain long-term control of viral replication. Therapeutic vaccination of HBV carriers is a promising strategy for the control of hepatitis B. Here the authors review new therapeutic vaccination strategies to treat chronic hepatitis B which may be introduced for patient treatment in the future.
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      New therapeutic vaccination strategies for the treatment of chronic hepatitis B

        Corresponding author: Michael Roggendorf, michael.roggendorf@uni-due.de
      • Institute for Virology, University Hospital of Essen, University of Duisburg-Essen, Virchowstraβe 179, 45122 Essen, Germany
      • Received Date: 21 December 2013
      • Accepted Date: 08 January 2014
      • Published Date: 17 January 2014

      Abstract: Chronic hepatitis B virus (CHB) is currently treated with either interferon-based or nucleot(s)ide-based antiviral therapies. However, treatment with pegylated interferon alpha results in a durable antiviral response in only about 30% patients and is associated with side effects. Most patients receiving nucleot(s)ide analogue treatment do not establish long-term, durable control of infection and have rebounding viremia after cessation of therapy. Thus, novel therapy strategies are necessary to achieve the induction of potent and durable antiviral immune responses of the patients which can maintain long-term control of viral replication. Therapeutic vaccination of HBV carriers is a promising strategy for the control of hepatitis B. Here the authors review new therapeutic vaccination strategies to treat chronic hepatitis B which may be introduced for patient treatment in the future.

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