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Volume 31 Issue 2
April 2016
    Citation: Jianjian Li, Lin Li, Shaomin Yang, Jingyun Li, Mi Zhang, Cuixian Yang, Jiafa Liu, Huiqin Li. Identification and characterization of two human immunodeficiency virus type 1 unique recombinant forms from Yunnan, China .VIROLOGICA SINICA, 2016, 31(2) : 184-187.  http://dx.doi.org/10.1007/s12250-015-3671-7
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    Identification and characterization of two human immunodeficiency virus type 1 unique recombinant forms from Yunnan, China

    • 1.

      Yunnan Provincial Hospital of Infectious Disease, AIDS Care Center (YNACC), Kunming 650301, China

    • 2.

      Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China

    • Corresponding author: Huiqin Li, ynacclhq@hotmail.com, ORCID: 0000-0002-9742-1105
    • These authors contributed equally to this work.
    • Published Date: 31 January 2016
      Available online: 01 April 2016
    • Recombination contributes greatly to the diversity of human immunodeficiency virus type 1 (HIV-1). A large number of recombinant strains have been found in China, particularly in Yunnan, which is considered the HIV-1 epicenter of China. Surveillance of unique recombinant forms is helpful for prediction of new circulating recombinant forms. In this study, we identified two unique recombinant forms of HIV-1 in Yunnan Province. The near full-length genomes of HIV-1 strains were amplified in three parts, and the genomic structures of two strains (12YN10159 and 12YN10192) were analyzed. Strain 12YN10159 was comprised of subtypes C and CRF01_AE, while strain 12YN10192 was comprised of subtypes B and C. Genomic breakpoints were different from all previously reported strains. The data emphasized that more surveillance of unique strains of HIV is needed in Yunnan.
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      Identification and characterization of two human immunodeficiency virus type 1 unique recombinant forms from Yunnan, China

        Corresponding author: Huiqin Li, ynacclhq@hotmail.com
      • 1. Yunnan Provincial Hospital of Infectious Disease, AIDS Care Center (YNACC), Kunming 650301, China
      • 2. Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China
      • Published Date: 31 January 2016

      Abstract: Recombination contributes greatly to the diversity of human immunodeficiency virus type 1 (HIV-1). A large number of recombinant strains have been found in China, particularly in Yunnan, which is considered the HIV-1 epicenter of China. Surveillance of unique recombinant forms is helpful for prediction of new circulating recombinant forms. In this study, we identified two unique recombinant forms of HIV-1 in Yunnan Province. The near full-length genomes of HIV-1 strains were amplified in three parts, and the genomic structures of two strains (12YN10159 and 12YN10192) were analyzed. Strain 12YN10159 was comprised of subtypes C and CRF01_AE, while strain 12YN10192 was comprised of subtypes B and C. Genomic breakpoints were different from all previously reported strains. The data emphasized that more surveillance of unique strains of HIV is needed in Yunnan.

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