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Citation: Na Zhang, Youyang Ke, Leiliang Zhang. Interplay between hepatitis C virus and ARF4 [J].VIROLOGICA SINICA, 2017, 32(6) : 533-536.  http://dx.doi.org/10.1007/s12250-017-4000-0

Interplay between hepatitis C virus and ARF4

  • Corresponding author: Youyang Ke, keyouyang001@163.com, ORCID: 0000-0002-3458-496X
    Leiliang Zhang, armzhang@hotmail.com, ORCID: 0000-0002-7015-9661
  • Received Date: 14 April 2017
    Accepted Date: 17 July 2017
    Published Date: 18 August 2017
  • In summary, we show here that HCV infection is associated with an upregulation of ARF4, which promotes HCV replication. Upon HCV infection, CREB3 was redistributed to nucleus and activated ARF4 transcription. Our studies demonstrate a host factor ARF4 upregulated in HCV replication, which may provide new therapeutic targets for antiviral therapy.

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    1. Farhat R, Seron K, Ferlin J, et al. 2016. Cell Microbiol, 18: 1121–1133.
        doi: 10.1111/cmi.v18.8

    2. Gillingham AK, Munro S. 2007. Annu Rev Cell Dev Biol, 23: 579–611.
        doi: 10.1146/annurev.cellbio.23.090506.123209

    3. Jang SY, Jang SW, Ko J. 2012. Cancer Lett, 314: 185–197.
        doi: 10.1016/j.canlet.2011.09.028

    4. Jin DY, Wang HL, Zhou Y, et al. 2000. EMBO J, 19: 729–740.
        doi: 10.1093/emboj/19.4.729

    5. Li H, Yang X, Yang G, et al. 2014. J Virol, 88: 5956–5966.
        doi: 10.1128/JVI.03738-13

    6. Matto M, Sklan EH, David N, et al. 2011. J Virol, 85: 946–956.
        doi: 10.1128/JVI.00753-10

    7. Raggo C, Rapin N, Stirling J, et al. 2002. Mol Cell Biol, 22: 5639–5649.
        doi: 10.1128/MCB.22.16.5639-5649.2002

    8. Reiling JH, Olive AJ, Sanyal S, et al. 2013. Nat Cell Biol, 15: 1473–1485.
        doi: 10.1038/ncb2865

    9. Tai AW, Benita Y, Peng LF, et al. 2009. Cell Host Microbe, 5: 298–307.
        doi: 10.1016/j.chom.2009.02.001

    10. Zhang L, Hong Z, Lin W, et al. 2012. PLoS One, 7: e32135.
        doi: 10.1371/journal.pone.0032135

    11. Zhang N, Yin P, Zhou L, et al. 2016. Biochem Biophys Res Commun, 475: 31–36.
        doi: 10.1016/j.bbrc.2016.05.024

    12. Zhou LY, Zhang LL. 2016. World J Gastroenterol, 22: 1477–1486.
        doi: 10.3748/wjg.v22.i4.1477

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    Interplay between hepatitis C virus and ARF4

      Corresponding author: Youyang Ke, keyouyang001@163.com
      Corresponding author: Leiliang Zhang, armzhang@hotmail.com
    • 1. MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100176, China
    • 2. Department of Emergency, 171st Hospital of PLA, Jiujiang 332000, China

    Abstract: In summary, we show here that HCV infection is associated with an upregulation of ARF4, which promotes HCV replication. Upon HCV infection, CREB3 was redistributed to nucleus and activated ARF4 transcription. Our studies demonstrate a host factor ARF4 upregulated in HCV replication, which may provide new therapeutic targets for antiviral therapy.