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Volume 34 Issue 3
June 2019
    Citation: Shuai Liu, Long Li, Lingbing Tan, Xiaozhen Liang. Inhibition of Herpes Simplex Virus-1 Replication by Natural Compound Honokiol .VIROLOGICA SINICA, 2019, 34(3) : 315-323.  http://dx.doi.org/10.1007/s12250-019-00104-5
    shu

    Inhibition of Herpes Simplex Virus-1 Replication by Natural Compound Honokiol

    cstr: 32224.14.s12250-019-00104-5
    • 1.

      University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100039, China

    • 2.

      Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Shanghai 200031, China

    • Corresponding author: Xiaozhen Liang, xzliang@ips.ac.cn
    • Shuai Liu and Long Li these authors have contributed equally contribution to the work
    • Received Date: 29 November 2018
      Accepted Date: 05 March 2019
      Published Date: 26 March 2019
      Available online: 01 June 2019
    • Honokiol is a pleiotropic natural compound isolated from Magnolia and has multiple biological and clinically relevant effects, including anticancer and antimicrobial function. However, the antiviral activity of honokiol has not yet been well studied. Here we showed that honokiol had no effect on herpes simplex virus-1 (HSV-1) entry, but inhibited HSV-1 viral DNA replication, gene expression and the production of new progeny viruses. The combination of honokiol and clinical drug acyclovir augmented inhibition of HSV-1 infection. Our results illustrate that honokiol could be a potential new candidate for clinical consideration in the treatment of HSV-1 infection alone or combination with other therapeutics.
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      Inhibition of Herpes Simplex Virus-1 Replication by Natural Compound Honokiol

        Corresponding author: Xiaozhen Liang, xzliang@ips.ac.cn
      • 1. University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100039, China
      • 2. Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Shanghai 200031, China
      • Received Date: 29 November 2018
      • Accepted Date: 05 March 2019
      • Published Date: 26 March 2019

      Abstract: Honokiol is a pleiotropic natural compound isolated from Magnolia and has multiple biological and clinically relevant effects, including anticancer and antimicrobial function. However, the antiviral activity of honokiol has not yet been well studied. Here we showed that honokiol had no effect on herpes simplex virus-1 (HSV-1) entry, but inhibited HSV-1 viral DNA replication, gene expression and the production of new progeny viruses. The combination of honokiol and clinical drug acyclovir augmented inhibition of HSV-1 infection. Our results illustrate that honokiol could be a potential new candidate for clinical consideration in the treatment of HSV-1 infection alone or combination with other therapeutics.

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