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Citation: Junsen Chen, Rui Huang, Yiwen Nie, Xinyue Wen, Ying Wu. Human Monoclonal Antibodies: On the Menu of Targeted Therapeutics Against COVID-19 [J].VIROLOGICA SINICA, 2020, 35(6) : 713-724.

Human Monoclonal Antibodies: On the Menu of Targeted Therapeutics Against COVID-19

  • Corresponding author: Ying Wu,, ORCID: 0000-0002-2716-6209
  • Received Date: 24 August 2020
    Accepted Date: 11 November 2020
    Published Date: 04 January 2021
    Available online: 01 December 2020
  • Coronavirus disease 2019 (COVID-19), reminiscent of the severe acute respiratory syndrome (SARS) outbreak in 2003, has been a tragic disaster to people all over the world. As there is no specific drug for COVID-19, neutralizing antibodies are attracting more and more attention as one of the most effective means to combat the pandemic. Here, we introduced the etiological and serological characteristics of COVID-19, discussed the current stage of development of human monoclonal antibodies against SARS-CoV-2 and summarized the antigenic epitopes in the S glycoprotein, which may deepen the understanding of the profile of immune recognition and response against SARS-CoV-2 and provide insight for the design of effective vaccines and antibody-based therapies.

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    Human Monoclonal Antibodies: On the Menu of Targeted Therapeutics Against COVID-19

      Corresponding author: Ying Wu,
    • 1. State Key Laboratory of Virology, School of Basic Medical Sciences, Wuhan University, Wuhan 430072, China
    • 2. Hubei Province Key Laboratory of Allergy and Immunology, Wuhan 430072, China

    Abstract: Coronavirus disease 2019 (COVID-19), reminiscent of the severe acute respiratory syndrome (SARS) outbreak in 2003, has been a tragic disaster to people all over the world. As there is no specific drug for COVID-19, neutralizing antibodies are attracting more and more attention as one of the most effective means to combat the pandemic. Here, we introduced the etiological and serological characteristics of COVID-19, discussed the current stage of development of human monoclonal antibodies against SARS-CoV-2 and summarized the antigenic epitopes in the S glycoprotein, which may deepen the understanding of the profile of immune recognition and response against SARS-CoV-2 and provide insight for the design of effective vaccines and antibody-based therapies.