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Volume 24 Issue 4
August 2009
    Citation: David C.J. Carpentier, Linda A. King. The Long Road to Understanding the Baculovirus P10 Protein .VIROLOGICA SINICA, 2009, 24(4) : 227-242.  http://dx.doi.org/10.1007/s12250-009-3045-0
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    The Long Road to Understanding the Baculovirus P10 Protein

    cstr: 32224.14.s12250-009-3045-0

    • School of Life Sciences, Oxford Brookes University, Headington Campus, Oxford, United Kingdom

    • Corresponding author: Linda A. King, laking@brookes.ac.uk
    • Present address; Oxford Expression Technologies Ltd, Oxford Brookes University, Headington Campus, Oxford, United Kingdom
    • Received Date: 31 January 2009
      Accepted Date: 27 May 2009
      Available online: 01 August 2009
    • The baculovirus P10 protein has always represented a mystery in the field of insect virology. Like the baculovirus polyhedrin protein it is expressed at high levels very late in infection. Homologues of the Autographa californica nucleopolyhedrovirus p10 gene are conserved in all Alphabaculoviruses and in other viruses of lepidopteran hosts yet is completely dispensable for virus replication and transmission. P10 is a microtubule interacting protein whose expression has been associated with the formation of a variety of complex and extensive cytoplasmic and nuclear structures. P10 has been associated with a number of roles during infection ranging from the formation of virus occlusion bodies, to affecting the rate of cellular and/or nuclear lysis during the final stages of the virus replication cycle. In this article we review recent work aimed at understanding the role of this enigmatic protein, putting them into context with recent advances in understanding of protein structure and function. We look back at a number of historical studies and observations, reanalysing their conclusions based on recent data and our own observations. The role of the P10 protein during baculovirus replication remains elusive, however, novel avenues of investigation have been identified that will, we are sure, eventually lead to an understanding of this protein.
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      The Long Road to Understanding the Baculovirus P10 Protein

        Corresponding author: Linda A. King, laking@brookes.ac.uk
      • School of Life Sciences, Oxford Brookes University, Headington Campus, Oxford, United Kingdom
      • Received Date: 31 January 2009
      • Accepted Date: 27 May 2009

      Abstract: The baculovirus P10 protein has always represented a mystery in the field of insect virology. Like the baculovirus polyhedrin protein it is expressed at high levels very late in infection. Homologues of the Autographa californica nucleopolyhedrovirus p10 gene are conserved in all Alphabaculoviruses and in other viruses of lepidopteran hosts yet is completely dispensable for virus replication and transmission. P10 is a microtubule interacting protein whose expression has been associated with the formation of a variety of complex and extensive cytoplasmic and nuclear structures. P10 has been associated with a number of roles during infection ranging from the formation of virus occlusion bodies, to affecting the rate of cellular and/or nuclear lysis during the final stages of the virus replication cycle. In this article we review recent work aimed at understanding the role of this enigmatic protein, putting them into context with recent advances in understanding of protein structure and function. We look back at a number of historical studies and observations, reanalysing their conclusions based on recent data and our own observations. The role of the P10 protein during baculovirus replication remains elusive, however, novel avenues of investigation have been identified that will, we are sure, eventually lead to an understanding of this protein.

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