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Volume 24 Issue 4
August 2009
    Citation: Eric B. Carstens. AcMNPV As A Model for Baculovirus DNA Replication .VIROLOGICA SINICA, 2009, 24(4) : 243-267.  http://dx.doi.org/10.1007/s12250-009-3047-y
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    AcMNPV As A Model for Baculovirus DNA Replication

    cstr: 32224.14.s12250-009-3047-y

    • Department of Microbiology and Immunology, Queen's University at Kingston, Kingston, ON K7L 3N6, Canada

    • Corresponding author: Eric B. Carstens, carstens@queensu.ca
    • Received Date: 31 January 2009
      Accepted Date: 11 May 2009
      Available online: 01 August 2009
    • Baculoviruses were first identified as insect-specific pathogens, and it was this specificity that lead to their use as safe, target specific biological pesticides. For the past 30 years, AcMNPV has served as the subject of intense basic molecular research into the baculovirus infectious cycle including the interaction of the virus with a continuous insect cell line derived from Spodoptera frugiperda. The studies on baculoviruese have led to an in-depth understanding of the physical organization of the viral genomes including many complete genomic sequences, the time course of gene expression, and the application of this basic research to the use of baculoviruses not only as insecticides, but also as a universal eukaryotic protein expression system, and a potential vector in gene therapy. A great deal has also been discovered about the viral genes required for the replication of the baculovirus genome, while much remains to be learned about the mechanism of viral DNA replication. This report outlines the current knowledge of the factors involved in baculovirus DNA replication, using data on AcMNPV as a model for most members of the Baculoviridae.
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      AcMNPV As A Model for Baculovirus DNA Replication

        Corresponding author: Eric B. Carstens, carstens@queensu.ca
      • Department of Microbiology and Immunology, Queen's University at Kingston, Kingston, ON K7L 3N6, Canada
      • Received Date: 31 January 2009
      • Accepted Date: 11 May 2009

      Abstract: Baculoviruses were first identified as insect-specific pathogens, and it was this specificity that lead to their use as safe, target specific biological pesticides. For the past 30 years, AcMNPV has served as the subject of intense basic molecular research into the baculovirus infectious cycle including the interaction of the virus with a continuous insect cell line derived from Spodoptera frugiperda. The studies on baculoviruese have led to an in-depth understanding of the physical organization of the viral genomes including many complete genomic sequences, the time course of gene expression, and the application of this basic research to the use of baculoviruses not only as insecticides, but also as a universal eukaryotic protein expression system, and a potential vector in gene therapy. A great deal has also been discovered about the viral genes required for the replication of the baculovirus genome, while much remains to be learned about the mechanism of viral DNA replication. This report outlines the current knowledge of the factors involved in baculovirus DNA replication, using data on AcMNPV as a model for most members of the Baculoviridae.

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