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Volume 24 Issue 4
August 2009
    Citation: Ran-ran WANG, Zhi-hong HU, Hua-lin WANG, Fei DENG. Virion Proteomics of Large DNA Viruses .VIROLOGICA SINICA, 2009, 24(4) : 268-284.  http://dx.doi.org/10.1007/s12250-009-3062-z
    shu

    Virion Proteomics of Large DNA Viruses

    cstr: 32224.14.s12250-009-3062-z

    • State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China

    • Corresponding author: Fei DENG, df@wh.iov.cn
    • Received Date: 08 April 2009
      Accepted Date: 12 May 2009
      Available online: 01 August 2009

      Fund Project: 973 Program 2009CB118903Programme Strategic Scientific Alliances between China and the Netherlands 2008AA000238National Science Foundation of China 30670078National Science Foundation of China 30630002

    • Large DNA viruses normally have complex structures with many of protein components derived from both viral and host origins. The development in proteomics, especially mass spectrometry identification techniques provide powerful tools for analyzing large viruses. In this review, we have summarized the recent achievements on proteomic studies of large DNA viruses, such as herpesvirus, poxvirus, nimavirus and baculoviruse. The proteomics of baculovirus occlusion-derived virions (ODV) were emphasized. Different mass spectrometry techniques used on various baculoviruses were introduced, and the identified structurally associated proteins of baculoviruses are summarized.
    • 加载中

      1. Afonso C L, Tulman E R, Lu Z, et al. 2001. Genome sequence of a baculovirus pathogenic for Culex nigripalpus. J Virol, 75: 11157-11165.
          doi: 10.1128/JVI.75.22.11157-11165.2001

      2. Baldick C J Jr, Shenk T. 1996. Proteins associated with purified human cytomegalovirus particles. J Virol, 70: 6097-6105.

      3. Bechtel J T, Winant R C, Ganem D. 2005. Host and viral proteins in the virion of Kaposi's sarcoma-associated herpesvirus. J Virol, 79: 4952-4964.
          doi: 10.1128/JVI.79.8.4952-4964.2005

      4. Belyavskyi M, Braunagel S C, Summers M D. 1998. The structural protein ODV-EC27 of Autographa californica nucleopolyhedrovirus is a multifunctional viral cyclin. Proc Natl Acad Sci USA, 95: 11205-11210.
          doi: 10.1073/pnas.95.19.11205

      5. Beniya H, Braunagel S C, Summers M D. 1998. Autographa californica nuclear polyhedrosis virus: sub-cellular localization and protein trafficking of BV/ODV-E26 to intranuclear membranes and viral envelopes. Virology, 240: 64-75.
          doi: 10.1006/viro.1997.8903

      6. Bortz E, Whitelegge J P, Jia Q, et al. 2003. Identifi-cation of proteins associated with murine gammaher-pesvirus 68 virions. J Virol, 77: 13425-13432.
          doi: 10.1128/JVI.77.24.13425-13432.2003

      7. Braunagel S C, Burks J K, Rosas-Acosta G, et al. 1999. Mutations within the Autographa californica nucleopoly-hedrovirus FP25K gene decrease the accumulation of ODV-E66 and alter its intranuclear transport. J Virol, 73: 8559-8570.

      8. Braunagel S C, Cox V, Summers M D. 2009. Bacu-lovirus data suggest a common but multifaceted pathway for sorting proteins to the inner nuclear membrane. J Virol, 83: 1280-1288.
          doi: 10.1128/JVI.01661-08

      9. Braunagel S C, Elton D M, Ma H, et al. 1996. Identification and analysis of an Autographa californica nuclear polyhedrosis virus structural protein of the occlusion-derived virus envelope: ODV-E56. Virology, 217: 97-110.
          doi: 10.1006/viro.1996.0097

      10. Braunagel S C, Guidry P A, Rosas-Acosta G, et al. 2001. Identification of BV/ODV-C42, an Autographa californica nucleopolyhedrovirus orf101-encoded structural protein detected in infected-cell complexes with ODV-EC27 and p78/83. J Virol, 75: 12331-12338.
          doi: 10.1128/JVI.75.24.12331-12338.2001

      11. Braunagel S C, He H, Ramamurthy P, et al. 1996. Transcription, translation, and cellular localization of three Autographa californica nuclear polyhedrosis virus structural proteins: ODV-E18, ODV-E35, and ODV-EC27. Virology, 222:100-114.
          doi: 10.1006/viro.1996.0401

      12. raunagel S C, Russell W K, Rosas-Acosta G, et al. 2003. Determination of the protein composition of the occlusion-derived virus of Autographa californica nucleopoly-hedrovirus. Proc Natl Acad Sci U S A, 100: 9797-9802.
          doi: 10.1073/pnas.1733972100

      13. Braunagel S C, Summers M D. 1994. Autographa californica nuclear polyhedrosis virus, PDV, and ECV viral envelopes and nucleocapsids: structural proteins, antigens, lipid and fatty acid profiles. Virology, 202: 315-328.
          doi: 10.1006/viro.1994.1348

      14. Braunagel S C, Summers M D. 2007. Molecular biology of the baculovirus occlusion-derived virus envelope. Curr Drug Targets, 8: 1084-1095.
          doi: 10.2174/138945007782151315

      15. Britt W J, Boppana S. 2004. Human cytomegalovirus virion proteins. Hum Immunol, 65: 395-402.
          doi: 10.1016/j.humimm.2004.02.008

      16. Burks J K, Summers M D, Braunagel S C. 2007. BV/ ODV-E26: a palmitoylated, multifunctional structural protein of Autographa californica nucleopolyhedrovirus. Virology, 361: 194-203.
          doi: 10.1016/j.virol.2006.11.007

      17. Chen W, Li Z, Li S, et al. 2006. Identification of Spodoptera litura multicapsid nucleopolyhedrovirus ORF97, a novel protein associated with envelope of occlusion-derived virus. Virus Genes, 32: 79-84.
          doi: 10.1007/s11262-005-5848-x

      18. Chen X, WilfredF I J, Tarchini R, et al. 2001. The sequence of the Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus genome. J Gen Virol, 82: 241-257.
          doi: 10.1099/0022-1317-82-1-241

      19. Chung C S, Chen C H, Ho M Y, et al. 2006. Vaccinia virus proteome: identification of proteins in vaccinia virus intracellular mature virion particles. J Virol, 80: 2127-2140.
          doi: 10.1128/JVI.80.5.2127-2140.2006

      20. Condit R C, Moussatche N, Traktman P. 2006. In a nutshell: structure and assembly of the vaccinia virion. Adv Virus Res, 66: 31-124.
          doi: 10.1016/S0065-3527(06)66002-8

      21. Deng F, Wang R, Fang M, et al. 2007. Proteomics analysis of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus identified two new occlusion-derived virus-associated proteins, HA44 and HA100. J Virol, 81: 9377-9385.
          doi: 10.1128/JVI.00632-07

      22. Durantel D, Croizier L, Ayres M D, et al. 1998. The pnk/pnl gene (ORF 86) of Autographa californica nucleopolyhedrovirus is a non-essential, immediate early gene. J Gen Virol, 79 (Pt 3): 629-637.

      23. Fang M, Dai X, Theilmann D A. 2007. Autographa californica multiple nucleopolyhedrovirus EXON0 (ORF141) is required for efficient egress of nucleocapsids from the nucleus. J Virol, 81:9859-9869.
          doi: 10.1128/JVI.00588-07

      24. Fang M, Nie Y, Dai X, et al. 2008. Identification of AcMNPV EXON0 (ac141) domains required for efficient production of budded virus, dimerization and association with BV/ODV-C42 and FP25. Virology, 375: 265-276.
          doi: 10.1016/j.virol.2008.01.036

      25. Fang M, Nie Y, Wang Q, et al. 2006. Open reading frame 132 of Helicoverpa armigera nucleopolyhedrovirus encodes a functional per os infectivity factor (PIF-2). J Gen Virol, 87: 2563-2569.
          doi: 10.1099/vir.0.81788-0

      26. Fang M, Wang H, Yuan L, et al. 2003. Open reading frame 94 of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus encodes a novel conserved occlusion-derived virion protein, ODV-EC43. J Gen Virol, 84: 3021-3027.
          doi: 10.1099/vir.0.19291-0

      27. Faulkner P, Kuzio J, Williams G V, et al. 1997. Analysis of p74, a PDV envelope protein of Autographa californica nucleopolyhedrovirus required for occlusion body infectivity in vivo. J Gen Virol, 78 (Pt 12): 3091-3100.

      28. Funk C J, Braunagel S C, Rohrmann G F. 1997. Baculovirus structure. In: The baculoviruses (Lois K. Miller, ed.), New York: Plenum Press, p7-32.

      29. Ge J Q, Yang Z N, Tang X D, et al. 2008. Characteri-zation of a nucleopolyhedrovirus with a deletion of the baculovirus core gene Bm67. J Gen Virol, 89: 766-774.
          doi: 10.1099/vir.0.83398-0

      30. Goley E D, Ohkawa T, Mancuso J, et al. 2006. Dynamic nuclear actin assembly by Arp2/3 complex and a baculovirus WASP-like protein. Science, 314: 464-467.
          doi: 10.1126/science.1133348

      31. Gong Y, Li Z, Wang L, et al. 2003. Characterization of bro-b gene of Spodoptera litura multicapsid nucleopoly-hedrovirus. Virus Genes, 27: 115-123.
          doi: 10.1023/A:1025773324560

      32. Guarino L A, Xu B, Jin J, et al. 1998. A virus-encoded RNA polymerase purified from baculovirus-infected cells. J Virol, 72: 7985-7991.

      33. Harrison R L, Jarvis D L, Summers M D. 1996. The role of the AcMNPV 25K gene, " FP25, " in baculovirus polh and p10 expression. Virology, 226: 34-46.
          doi: 10.1006/viro.1996.0625

      34. Harrison R L, Summers M D. 1995. Mutations in the Autographa californica multinucleocapsid nuclear poly-hedrosis virus 25 kDa protein gene result in reduced virion occlusion, altered intranuclear envelopment and enhanced virus production. J Gen Virol, 76 (Pt 6): 1451-1459.

      35. Herniou E A, Jehle J A. 2007. Baculovirus phylogeny and evolution. Curr Drug Targets, 8: 1043-1050.
          doi: 10.2174/138945007782151306

      36. Hong T, Braunagel S C, Summers M D. 1994. Trans-cription, translation, and cellular localization of PDV-E66: a structural protein of the PDV envelope of Autographa californica nuclear polyhedrosis virus. Virology, 204: 210-222.
          doi: 10.1006/viro.1994.1525

      37. Huang C, Zhang X, Lin Q, et al. 2002. Proteomic analysis of shrimp white spot syndrome viral proteins and characterization of a novel envelope protein VP466. Mol Cell Proteomics, 1: 223-231.
          doi: 10.1074/mcp.M100035-MCP200

      38. Iorio C, Vialard J E, McCracken S, et al. 1998. The late expression factors 8 and 9 and possibly the phosp-hoprotein p78/83 of Autographa californica multicapsid nucleopolyhedrovirus are components of the virus-in-duced RNA polymerase. Intervirology, 41: 35-46.
          doi: 10.1159/000024913

      39. Ishihama Y, Oda Y, Tabata T, et al. 2005. Exponentially modified protein abundance index (emPAI) for estimation of absolute protein amount in proteomics by the number of sequenced peptides per protein. Mol Cell Proteomics, 4: 1265-1272.
          doi: 10.1074/mcp.M500061-MCP200

      40. Jehle J A, Blissard G W, Bonning B C, et al. 2006. On the classification and nomenclature of baculoviruses: a proposal for revision. Arch Virol, 151: 1257-1266.
          doi: 10.1007/s00705-006-0763-6

      41. Jehle J A, Lange M, Wang H, et al. 2006. Molecular identification and phylogenetic analysis of baculoviruses from Lepidoptera. Virology, 346: 180-193.
          doi: 10.1016/j.virol.2005.10.032

      42. Jensen O N, Houthaeve T, Shevchenko A, et al. 1996. Identification of the major membrane and core proteins of vaccinia virus by two-dimensional electrophoresis. J Virol, 70: 7485-7497.

      43. Johannsen E, Luftig M, Chase M R, et al. 2004. Proteins of purified Epstein-Barr virus. Proc Natl Acad Sci USA, 101: 16286-16291.
          doi: 10.1073/pnas.0407320101

      44. Katsuma S, Nakanishi T, Shimada T. 2009. Bombyx mori nucleopolyhedrovirus FP25K is essential for main-taining a steady-state level of v-cath expression throug-hout the infection. Virus Res, 140: 155-160.
          doi: 10.1016/j.virusres.2008.11.014

      45. Kattenhorn L M, Mills R, Wagner M, et al. 2004. Identification of proteins associated with murine cytome-galovirus virions. J Virol, 78: 11187-11197.
          doi: 10.1128/JVI.78.20.11187-11197.2004

      46. Ke J, Wang J, Deng R, et al. 2008. Autographa californica multiple nucleopolyhedrovirus ac66 is required for the efficient egress of nucleocapsids from the nucleus, general synthesis of preoccluded virions and occlusion body formation. Virology, 374: 421-431.
          doi: 10.1016/j.virol.2007.12.033

      47. Kikhno I, Gutierrez S, Croizier L, et al. 2002. Characterization of pif, a gene required for the per os infectivity of Spodoptera littoralis nucleopolyhedrovirus. J Gen Virol, 83: 3013-3022.
          doi: 10.1099/0022-1317-83-12-3013

      48. Kool M, Ahrens C H, Goldbach R W, et al. 1994. Identification of genes involved in DNA replication of the Autographa californica baculovirus. Proc Natl Acad Sci USA, 91: 11212-11216.
          doi: 10.1073/pnas.91.23.11212

      49. Kuzio J, Jaques R, Faulkner P. 1989. Identification of p74, a gene essential for virulence of baculovirus occlusion bodies. Virology, 173: 759-763.
          doi: 10.1016/0042-6822(89)90593-X

      50. Lapointe R, Popham H J, Straschil U, et al. 2004. Characterization of two Autographa californica nucleo-polyhedrovirus proteins, Ac145 and Ac150, which affect oral infectivity in a host-dependent manner. J Virol, 78: 6439-6448.
          doi: 10.1128/JVI.78.12.6439-6448.2004

      51. Li G, Wang J, Deng R, et al. 2008. Characterization of AcMNPV with a deletion of ac68 gene. Virus Genes, 37: 119-127.
          doi: 10.1007/s11262-008-0238-9

      52. Li L, Li Z, Chen W, et al. 2006. Characterization of Spodoptera exigua multicapsid nucleopolyhedrovirus ORF100 and ORF101, two homologues of E. coli ChaB. Virus Res, 121: 42-50.
          doi: 10.1016/j.virusres.2006.03.014

      53. Li Y, Miller L K. 1995. Expression and localization of a baculovirus protein phosphatase. J Gen Virol, 76 (Pt 12): 2941-2948.

      54. Li Y, Miller L K. 1995. Properties of a baculovirus mutant defective in the protein phosphatase gene. J Virol, 69: 4533-4537.

      55. Li Y, Passarelli A L, Miller L K. 1993. Identification, sequence, and transcriptional mapping of lef-3, a baculo-virus gene involved in late and very late gene expression. J Virol, 67: 5260-5268.

      56. Li Z, Li L, Yu H, et al. 2006. Characterization of two homologues of ChaB in Spodoptera litura multicapsid nucleopolyhedrovirus. Gene, 372: 33-43.
          doi: 10.1016/j.gene.2005.11.029

      57. Li Z, Lin Q, Chen J, et al. 2007. Shotgun identification of the structural proteome of shrimp white spot syndrome virus and iTRAQ differentiation of envelope and nucleocapsid subproteomes. Mol Cell Proteomics, 6: 1609-1620.
          doi: 10.1074/mcp.M600327-MCP200

      58. Liu X, Chen K, Cai K, et al. 2008. Determination of Protein Composition and Host-Derived Proteins of Bombyx mori Nucleopolyhedrovirus by 2-Dimensional Electrophoresis and Mass Spectrometry. Intervirology, 51: 369-376.

      59. Loret S, Guay G, Lippe R. 2008. Comprehensive characterization of extracellular herpes simplex virus type 1 virions. J Virol, 82: 8605-8618.
          doi: 10.1128/JVI.00904-08

      60. Lu A, Carstens E B. 1992. Nucleotide sequence and transcriptional analysis of the p80 gene of Autographa californica nuclear polyhedrosis virus: a homologue of the Orgyia pseudotsugata nuclear polyhedrosis virus capsid-associated gene. Virology, 190: 201-209.
          doi: 10.1016/0042-6822(92)91206-A

      61. Lu A, Miller L K. 1995. Differential requirements for baculovirus late expression factor genes in two cell lines. J Virol, 69: 6265-6272.

      62. Lu A, Miller L K. 1995. The roles of eighteen baculovirus late expression factor genes in transcription and DNA replication. J Virol, 69: 975-982.

      63. Lu A, Miller L K. 1996. Species-specific effects of the hcf-1 gene on baculovirus virulence. J Virol, 70: 5123-5130.

      64. Maxwell K L, Frappier L. 2007. Viral proteomics. Microbiol Mol Biol Rev, 71: 398-411.
          doi: 10.1128/MMBR.00042-06

      65. McCarthy C B, Dai X, Donly C, et al. 2008. Autographa californica multiple nucleopolyhedrovirus ac142, a core gene that is essential for BV production and ODV envelopment. Virology, 372: 325-339.
          doi: 10.1016/j.virol.2007.10.019

      66. McCarthy C B, Theilmann D A. 2008. AcMNPV ac143 (odv-e18) is essential for mediating budded virus production and is the 30th baculovirus core gene. Virology, 375: 277-291.
          doi: 10.1016/j.virol.2008.01.039

      67. McLachlin J R, Miller L K. 1994. Identification and characterization of vlf-1, a baculovirus gene involved in very late gene expression. J Virol, 68: 7746-7756.

      68. Mikhailov V S, Okano K, Rohrmann G F. 2003. Baculovirus alkaline nuclease possesses a 5'-- > 3' exonuclease activity and associates with the DNA-binding protein LEF-3. J Virol, 77: 2436-2444.
          doi: 10.1128/JVI.77.4.2436-2444.2003

      69. Mikhailov V S, Okano K, Rohrmann G F. 2004. Specificity of the endonuclease activity of the baculovirus alkaline nuclease for single-stranded DNA. J Biol Chem, 279: 14734-14745.
          doi: 10.1074/jbc.M311658200

      70. Mikhailov V S, Rohrmann G F. 2002. Baculovirus replication factor LEF-1 is a DNA primase. J Virol, 76: 2287-2297.
          doi: 10.1128/jvi.76.5.2287-2297.2002

      71. O'Connor C M, Kedes D H. 2006. Mass spectrometric analyses of purified rhesus monkey rhadinovirus reveal 33 virion-associated proteins. J Virol, 80: 1574-1583.
          doi: 10.1128/JVI.80.3.1574-1583.2006

      72. Ohkawa T, Rowe A R, and Volkman L E. 2002. Identification of six Autographa californica multicapsid nucleopolyhedrovirus early genes that mediate nuclear localization of G-actin. J Virol, 76: 12281-12289.
          doi: 10.1128/JVI.76.23.12281-12289.2002

      73. Ohkawa T, Washburn J O, Sitapara R, et al. 2005. Specific binding of Autographa californica M nucleopoly-hedrovirus occlusion-derived virus to midgut cells of Heliothis virescens larvae is mediated by products of pif genes Ac119 and Ac022 but not by Ac115. J Virol, 79: 15258-15264.
          doi: 10.1128/JVI.79.24.15258-15264.2005

      74. Okano K, Vanarsdall A L, Rohrmann G F. 2004. Characterization of a baculovirus lacking the alkaline nuclease gene. J Virol, 78: 10650-10656.
          doi: 10.1128/JVI.78.19.10650-10656.2004

      75. Olszewski J, Miller L K. 1997. Identification and characterization of a baculovirus structural protein, VP1054, required for nucleocapsid formation. J Virol, 71: 5040-5050.

      76. Olszewski J, Miller L K. 1997. A role for baculovirus GP41 in budded virus production. Virology, 233: 292-301.
          doi: 10.1006/viro.1997.8612

      77. Passarelli A L, Miller L K. 1993. Identification and characterization of lef-1, a baculovirus gene involved in late and very late gene expression. J Virol, 67: 3481-3488.

      78. Passarelli A L, Miller L K. 1994. In vivo and in vitro analyses of recombinant baculoviruses lacking a functional cg30 gene. J Virol, 68: 1186-1190.

      79. Pearson M N, Groten C, Rohrmann G F. 2000. Identification of the lymantria dispar nucleopoly-hedrovirus envelope fusion protein provides evidence for a phylogenetic division of the Baculoviridae. J Virol, 74: 6126-6131.
          doi: 10.1128/JVI.74.13.6126-6131.2000

      80. Pearson M N, Russell R L, Rohrmann G F, et al. 1988. p39, a major baculovirus structural protein: immunocy-tochemical characterization and genetic location. Virology, 167: 407-413.

      81. Perera O, Green T B, Stevens S M, et al. 2007. Proteins associated with Culex nigripalpus nucleopolyhedrovirus occluded virions. J Virol, 81: 4585-4590.
          doi: 10.1128/JVI.02391-06

      82. Pijlman G P, Pruijssers A J, Vlak J M. 2003. Identification of pif-2, a third conserved baculovirus gene required for per os infection of insects. J Gen Virol, 84: 2041-2049.
          doi: 10.1099/vir.0.19133-0

      83. Prikhod'ko G G, Wang Y, Freulich E, et al. 1999. Baculovirus p33 binds human p53 and enhances p53-mediated apoptosis. J Virol, 73: 1227-1234.

      84. Rixon F J, Chiu W. 2003. Studying large viruses. Adv Protein Chem, 64: 379-408.
          doi: 10.1016/S0065-3233(03)01011-8

      85. Rohrmann G F. 2008. The AcMNPV genome: Gene content, conservation and function. Baculovirus Molecular Biology. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information. http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=bacvir.

      86. Rosas-Acosta G, Braunagel S C, Summers M D. 2001. Effects of deletion and overexpression of the Autographa californica nuclear polyhedrosis virus FP25K gene on synthesis of two occlusion-derived virus envelope proteins and their transport into virus-induced intranuclear membranes. J Virol, 75: 10829-10842.
          doi: 10.1128/JVI.75.22.10829-10842.2001

      87. Russell R L, Rohrmann G F. 1993. A 25-kDa protein is associated with the envelopes of occluded baculovirus virions. Virology, 195: 532-540.
          doi: 10.1006/viro.1993.1404

      88. Russell R L, Rohrmann G F. 1997. Characterization of P91, a protein associated with virions of an Orgyia pseudotsugata baculovirus. Virology, 233: 210-223.
          doi: 10.1006/viro.1997.8599

      89. Sheng Z, Charbonneau H. 1993. The baculovirus Autographa californica encodes a protein tyrosine phosp-hatase. J Biol Chem, 268: 4728-4733.

      90. Slack J, Arif B M. 2007. The baculoviruses occlusion-derived virus: virion structure and function. Adv Virus Res, 69: 99-165.

      91. Song J, Wang R, Deng F, et al. 2008. Functional studies of per os infectivity factors of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus. J Gen Virol, 89: 2331-2338.
          doi: 10.1099/vir.0.2008/002352-0

      92. Summers M D, Smith G E. 1975. Trichoplusia ni granulosis virus granulin: a phenol-soluble, phosphory-lated protein. J Virol, 16: 1108-1116.

      93. Takagi T, Taylor G S, Kusakabe T, et al. 1998. A protein tyrosine phosphatase-like protein from baculovirus has RNA 5'-triphosphatase and diphosphatase activities. Proc Natl Acad Sci USA, 95: 9808-9812.
          doi: 10.1073/pnas.95.17.9808

      94. Takahashi T, Oie M, Ichihashi Y. 1994. N-terminal amino acid sequences of vaccinia virus structural proteins. Virology, 202: 844-852.
          doi: 10.1006/viro.1994.1406

      95. Tang X D, Xu Y P, Yu L L, et al. 2008. Characterization of a Bombyx mori nucleopolyhedrovirus with Bmvp80 disruption. Virus Res, 138: 81-88.
          doi: 10.1016/j.virusres.2008.08.013

      96. Theilmann D A, Chantler J K, Stweart S, et al. 1996. Characterization of a highly conserved baculovirus stru-ctural protein that is specific for occlusion-derived virions. Virology, 218: 148-158.
          doi: 10.1006/viro.1996.0175

      97. Thiem S M, Miller L K. 1989. Identification, sequence, and transcriptional mapping of the major capsid protein gene of the baculovirus Autographa californica nuclear polyhedrosis virus. J Virol, 63: 2008-2018.

      98. Todd J W, Passarelli A L, Miller L K. 1995. Eighteen baculovirus genes, including lef-11, p35, 39K, and p47, support late gene expression. J Virol, 69:968-974.

      99. Tsai J M, Wang H C, Leu J H, et al. 2004. Genomic and proteomic analysis of thirty-nine structural proteins of shrimp white spot syndrome virus. J Virol, 78: 11360-11370.
          doi: 10.1128/JVI.78.20.11360-11370.2004

      100. Tsai J M, Wang H C, Leu J H, et al. 2006. Identifi-cation of the nucleocapsid, tegument, and envelope proteins of the shrimp white spot syndrome virus virion. J Virol, 80: 3021-3029.
          doi: 10.1128/JVI.80.6.3021-3029.2006

      101. Tweeten K A, Bulla L A, Consigli R A. 1980. Characterization of an Extremely Basic Protein Derived from Granulosis Virus Nucleocapsids. J Virol, 33: 866-876.

      102. Van Oers M M, Vlak J M. 2007. Baculovirus genomics. Curr Drug Targets, 8:1051-1068.
          doi: 10.2174/138945007782151333

      103. Vanarsdall A L, Okano K, Rohrmann G F. 2006. Characterization of the role of very late expression factor 1 in baculovirus capsid structure and DNA processing. J Virol, 80: 1724-1733.
          doi: 10.1128/JVI.80.4.1724-1733.2006

      104. Vanarsdall A L, Pearson M N, Rohrmann G F. 2007. Characterization of baculovirus constructs lacking either the Ac 101, Ac 142, or the Ac 144 open reading frame. Virology, 367: 187-195.
          doi: 10.1016/j.virol.2007.05.003

      105. Varnum S M, Streblow D N, Monroe M E, et al. 2004. Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome. J Virol, 78: 10960-10966.
          doi: 10.1128/JVI.78.20.10960-10966.2004

      106. Vialard J E, Richardson C D. 1993. The 1, 629-nucleotide open reading frame located downstream of the Autographa californica nuclear polyhedrosis virus poly-hedrin gene encodes a nucleocapsid-associated phospho-protein. J Virol, 67: 5859-5866.

      107. Vigdorovich V, Miller A D, Strong R K. 2007. Ability of hyaluronidase 2 to degrade extracellular hyaluronan is not required for its function as a receptor for jaagsiekte sheep retrovirus. J Virol, 81: 3124-3129.
          doi: 10.1128/JVI.02177-06

      108. Wang L, Yu J, Yin C, et al. 2002. Characterization of a J domain gene of Spodoptera litura multicapsid nucleopoly-hedrovirus. Virus Genes, 25: 291-297.
          doi: 10.1023/A:1020980109450

      109. Wang M, Tan Y, Yin F, et al. 2008. The F-like protein Ac23 enhances the infectivity of the budded virus of gp64-null Autographa californica multinucleocapsid nuc-leopoly hedrovirus pseudotyped with baculovirus envelope fusion protein F. J Virol, 82: 9800-9804.
          doi: 10.1128/JVI.00759-08

      110. Wang Q, Wang Y, Liang C, et al. 2008. Identification of a hydrophobic domain of HA2 essential to morphogenesis of Helicoverpa armigera nucleopolyhedrovirus. J Virol, 82: 4072-4081.
          doi: 10.1128/JVI.02319-07

      111. Wang Y, Wang Q, Liang C, et al. 2008. Autographa californica multiple nucleopolyhedrovirus nucleocapsid protein BV/ODV-C42 mediates the nuclear entry of P78/ 83. J Virol, 82: 4554-4561.
          doi: 10.1128/JVI.02510-07

      112. Whitford M, Faulkner P. 1992. A structural polypeptide of the baculovirus Autographa californica nuclear polyhedrosis virus contains O-linked N-acetylglucosamine. J Virol, 66: 3324-3329.

      113. Wilson M E, Mainprize T H, Friesen P D, et al. 1987. Location, transcription, and sequence of a baculovirus gene encoding a small arginine-rich polypeptide. J Virol, 61: 661-666.

      114. Wilson M E, Price K H. 1988. Association of Autographa californica nuclear polyhedrosis virus (AcMNPV) with the nuclear matrix. Virology, 167: 233-241.
          doi: 10.1016/0042-6822(88)90073-6

      115. Wolgamot G M, Gross C H, Russell R L, et al. 1993. Immunocytochemical characterization of p24, a baculovirus capsid-associated protein. J Gen Virol, 74 (Pt 1): 103-107.

      116. Wu W, Liang H, Kan J, et al. 2008. Autographa californica Multiple Nucleopolyhedrovirus 38K Is a Novel Nucleocapsid Protein That Interacts with VP1054, VP39, VP80 and Itself. J Virol, 82: 12356-12364.
          doi: 10.1128/JVI.00948-08

      117. Wu W, Lin T, Pan L, et al. 2006. Autographa californica multiple nucleopolyhedrovirus nucleocapsid assembly is interrupted upon deletion of the 38K gene. J Virol, 80: 11475-11485.
          doi: 10.1128/JVI.01155-06

      118. Xie X, Xu L, Yang F. 2006. Proteomic analysis of the major envelope and nucleocapsid proteins of white spot syndrome virus. J Virol, 80: 10615-10623.
          doi: 10.1128/JVI.01452-06

      119. Xu H J, Yang Z N, Wang F, et al. 2006. Bombyx mori nucleopolyhedrovirus ORF79 encodes a 28-kDa structural protein of the ODV envelope. Arch Virol, 151: 681-695.
          doi: 10.1007/s00705-005-0664-0

      120. Xu H J, Yang Z N, Zhao J F, et al. 2008. Bombyx mori nucleopolyhedrovirus ORF56 encodes an occlusion-derived virus protein and is not essential for budded virus production. J Gen Virol, 89: 1212-1219.
          doi: 10.1099/vir.0.83633-0

      121. Yoder J D, Chen T S, Gagnier C R, et al. 2006. Pox proteomics: mass spectrometry analysis and identification of Vaccinia virion proteins. Virol J, 3: 10.
          doi: 10.1186/1743-422X-3-10

      122. Zachertowska A, Brewer D, Evans D H. 2006. Characterization of the major capsid proteins of myxoma virus particles using MALDI-TOF mass spectrometry. J Virol Methods, 132: 1-12.
          doi: 10.1016/j.jviromet.2005.08.015

      123. Zemskov E A, Kang W, Maeda S. 2000. Evidence for nucleic acid binding ability and nucleosome association of Bombyx mori nucleopolyhedrovirus BRO proteins. J Virol, 74: 6784-6789.
          doi: 10.1128/JVI.74.15.6784-6789.2000

      124. Zhang J H, Ohkawa T, Washburn J O, et al. 2005. Effects of Ac150 on virulence and pathogenesis of Autographa californica multiple nucleopolyhedrovirus in noctuid hosts. J Gen Virol, 86: 1619-1627.
          doi: 10.1099/vir.0.80930-0

      125. Zhang X, Huang C, Tang X, et al. 2004. Identification of structural proteins from shrimp white spot syndrome virus (WSSV) by 2DE-MS. Proteins, 55: 229-235.
          doi: 10.1002/prot.10640

      126. Zhu F X, Chong J M, Wu L, et al. 2005. Virion proteins of Kaposi's sarcoma-associated herpesvirus. J Virol, 79: 800-811.
          doi: 10.1128/JVI.79.2.800-811.2005

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      Virion Proteomics of Large DNA Viruses

        Corresponding author: Fei DENG, df@wh.iov.cn
      • State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
      • Received Date: 08 April 2009
      • Accepted Date: 12 May 2009
      Fund Project:  973 Program 2009CB118903Programme Strategic Scientific Alliances between China and the Netherlands 2008AA000238National Science Foundation of China 30670078National Science Foundation of China 30630002

      Abstract: Large DNA viruses normally have complex structures with many of protein components derived from both viral and host origins. The development in proteomics, especially mass spectrometry identification techniques provide powerful tools for analyzing large viruses. In this review, we have summarized the recent achievements on proteomic studies of large DNA viruses, such as herpesvirus, poxvirus, nimavirus and baculoviruse. The proteomics of baculovirus occlusion-derived virions (ODV) were emphasized. Different mass spectrometry techniques used on various baculoviruses were introduced, and the identified structurally associated proteins of baculoviruses are summarized.

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