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Volume 25 Issue 4
August 2010
    Citation: Xin LIANG, Zhi-yuan LI. Ion Channels as Antivirus Targets .VIROLOGICA SINICA, 2010, 25(4) : 267-280.  http://dx.doi.org/10.1007/s12250-010-3136-y
    shu

    Ion Channels as Antivirus Targets

    cstr: 32224.14.s12250-010-3136-y

    • State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China

    • Corresponding author: Zhi-yuan LI, li_zhiyuan@gibh.ac.cn
    • Received Date: 24 February 2010
      Accepted Date: 10 May 2010
      Available online: 01 August 2010
    • Ion channels are membrane proteins that are found in a number of viruses and which are of crucial physiological importance in the viral life cycle. They have one common feature in that their action mode involves a change of electrochemical or proton gradient across the bilayer lipid membrane which modulates viral or cellular activity. We will discuss a group of viral channel proteins that belong to the viroproin family, and which participate in a number of viral functions including promoting the release of viral particles from cells. Blocking these channel-forming proteins may be “lethal”, which can be a suitable and potential therapeutic strategy. In this review we discuss seven ion channels of viruses which can lead serious infections in human beings: M2 of influenza A, NB and BM2 of influenza B, CM2 of influenza C, Vpu of HIV-1, p7 of HCV and 2B of picornaviruses.
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      Ion Channels as Antivirus Targets

        Corresponding author: Zhi-yuan LI, li_zhiyuan@gibh.ac.cn
      • State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
      • Received Date: 24 February 2010
      • Accepted Date: 10 May 2010

      Abstract: Ion channels are membrane proteins that are found in a number of viruses and which are of crucial physiological importance in the viral life cycle. They have one common feature in that their action mode involves a change of electrochemical or proton gradient across the bilayer lipid membrane which modulates viral or cellular activity. We will discuss a group of viral channel proteins that belong to the viroproin family, and which participate in a number of viral functions including promoting the release of viral particles from cells. Blocking these channel-forming proteins may be “lethal”, which can be a suitable and potential therapeutic strategy. In this review we discuss seven ion channels of viruses which can lead serious infections in human beings: M2 of influenza A, NB and BM2 of influenza B, CM2 of influenza C, Vpu of HIV-1, p7 of HCV and 2B of picornaviruses.

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