-
Ago H, Adachi T, Yoshida A, et al. 1999. Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Structure, 7: 1417-1426.
doi: 10.1016/S0969-2126(00)80031-3
-
Arasappan A, Bennett F, Bogen S L, et al. 2010. Discovery of Narlaprevir (SCH 900518): a potent, second generation HCV NS3 serine protease inhibitor. ACS Med Chem Lett, 2-15-2010
-
Bain V G, Kaita K D, Marotta P, et al. 2008. Safety and antiviral activity of albinterferon alfa-2b dosed every four weeks in genotype 2/3 chronic hepatitis C patients. Clin Gastroenterol Hepatol, 6: 701-706.
doi: 10.1016/j.cgh.2008.02.056
-
Bartenschlager R, Ahlborn-Laake L, Mous J, et al. 1993. Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions. J Virol. 67: 3835-3844.
-
Bartosch B, Dubuisson J, Cosset F L. 2003. Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes. J Exp Med, 197: 633-642.
doi: 10.1084/jem.20021756
-
Bavisotto L, Wang C, Jacobson I, et al. 2007. Antiviral, pharmacokinetic and safety data for GS-9190, a non-nucleoside HCV NS5B polymerase inhibitor, in a phase-1 trial in HCV genotype 1 infected patients. 58th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, MA.
-
Bernstein B, Menon R M, Klein C E, et al. 2009. Pharmacokinetics, safety and tolerability of the HCV protease inhibitor ABT-450 with ritonavir following multiple ascending doses in healthy adult volunteers. HepDART 2009, Kohala Coast, Hawaii, USA.
-
Blight K J, Kolykhalov A A, Rice C M. 2000. Efficient initiation of HCV RNA replication in cell culture. Science, 290: 1972-1974.
doi: 10.1126/science.290.5498.1972
-
Borawski J, Troke P, Puyang X, et al. 2009. Class Ⅲ phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication. J Virol, 83: 10058-10074.
doi: 10.1128/JVI.02418-08
-
Borowski P, Deinert J, Schalinski S, et al. 2003. Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses. Eur J Biochem, 270: 1645-1653.
doi: 10.1046/j.1432-1033.2003.03540.x
-
Borowski P, Lang M, Haag A, et al. 2007. Tropolone and its derivatives as inhibitors of the helicase activity of hepatitis C virus nucleotide triphosphatase/helicase. Antivir Chem Chemother, 18: 103-109.
doi: 10.1177/095632020701800206
-
Brainard D M, Anderson M S, Petry A S, et al. 2009. Safety and antiviral activity of NS5B polymerase inhibitor MK-3281in genotype 1 and 3 HCV-infected patients. 60th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, MA.
-
Bressanelli S, Tomei L, Roussel A, et al. 1999. Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Proc Natl Acad Sci USA, 96: 13034-13039.
doi: 10.1073/pnas.96.23.13034
-
Bukh J. 2004. A critical role for the chimpanzee model in the study of hepatitis C. Hepatology, 39: 1469-1475.
doi: 10.1002/(ISSN)1527-3350
-
Chatterji U, Bobardt M, Lim P, et al. 2010. Cyclophilin A-Independent Recruitment of NS5A and NS5B Into HCV Replication Complexes. J Gen Virol, In press.
-
Chatterji U, Bobardt M, Selvarajah S, et al. 2009. The isomerase active site of cyclophilin A is critical for HCV replication. J Biol Chem, 284: 16998-17005.
doi: 10.1074/jbc.M109.007625
-
Chatterji U, Bobardt M, Selvarajah S, et al. 2009. The isomerase active site of cyclophilin A is critical for hepatitis C virus replication. J Biol Chem, 284: 16998-17005.
doi: 10.1074/jbc.M109.007625
-
Chen C M, He Y, Lu L, et al. 2007. Activity of a potent hepatitis C virus polymerase inhibitor in the chimpanzee model. Antimicrob Agents Chemother, 51: 4290-4296.
doi: 10.1128/AAC.00723-07
-
Cho N J, Dvory-Sobol H, Lee C, et al. 2010. Identification of a class of HCV inhibitors directed against the nonstructural protein NS4B. Science Translational Medicine, 2: 1-8.
-
Choo Q L, Kuo G, Weiner A J, et al. 1989. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science, 244: 359-362.
doi: 10.1126/science.2523562
-
Ciesek S, Steinmann E, Wedemeyer H, et al. 2009. Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A. Hepatology, 50: 1638-1645.
doi: 10.1002/hep.23281
-
Clinicaltrials. gov. http://clinicaltrials.gov/.
-
Coelmont L, Kaptein S, Paeshuyse J, et al. 2009. Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors. Antimicrob Agents Chemother, 53: 967-976.
doi: 10.1128/AAC.00939-08
-
Colonno R. 2010. Discovery and characterization of PPI-461, a potent and selective HCV NS5A inhibitor with broad-spectrum coverage of all HCV genotypes. HCV Drug Discovery, San Diego, CA.
-
Cooper C, Lawitz E J, Ghali P, et al. 2009. Evaluation of VCH-759 monotherapy in hepatitis C infection. J Hepatol, 2009; 51 (1): 39-46
doi: 10.1016/j.jhep.2009.03.015
-
Darke P L, Jacobs A R, Waxman L, et al. 1999. Inhibition of hepatitis C virus NS2/3 processing by NS4A peptides. Implications for control of viral processing. J Biol Chem, 274: 34511-34514.
doi: 10.1074/jbc.274.49.34511
-
Einav S, Gerber D, Bryson P D, et al. 2008. Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat Biotechnol, 26: 1019-1027.
doi: 10.1038/nbt.1490
-
Elazar M, Liu M, McKenna S A, et al. 2009. The anti-hepatitis C agent nitazoxanide induces phosphorylation of eukaryotic initiation factor 2alpha via protein kinase activated by double-stranded RNA activation. Gastroenterology, 137: 1827-1835.
doi: 10.1053/j.gastro.2009.07.056
-
Erhardt A, Deterding K, Benhamou Y, et al. 2009. Safety, pharmacokinetics and antiviral effect of BILB 1941, a novel hepatitis C virus RNA polymerase inhibitor, after 5 days oral treatment. Antivir Ther, 14: 23-32.
-
Evans M J, von H T, Tscherne D M, et al. 2007. Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry. Nature, 446: 801-805.
doi: 10.1038/nature05654
-
Feldstein A, Kleiner D, Kravetz D, et al. 2009. Severe hepatocellular injury with apoptosis induced by a hepatitis C polymerase inhibitor. J Clin Gastroenterol, 43: 374-381.
doi: 10.1097/MCG.0b013e318178d91f
-
Fernandes F, Poole D S, Hoover S, et al. 2007. Sensitivity of hepatitis C virus to cyclosporine A depends on nonstructural proteins NS5A and NS5B. Hepatology, 46: 1026-1033.
-
Firbas C, Boehm T, Buerger V, et al. 2010. Immunogenicity and safety of different injection routes and schedules of IC41, a Hepatitis C virus (HCV) peptide vaccine. Vaccine, 28: 2397-2407.
doi: 10.1016/j.vaccine.2009.12.072
-
Firbas C, Jilma B, Tauber E, et al. 2006. Immunogenicity and safety of a novel therapeutic hepatitis C virus (HCV) peptide vaccine: a randomized, placebo controlled trial for dose optimization in 128 healthy subjects. Vaccine, 24: 4343-4353.
doi: 10.1016/j.vaccine.2006.03.009
-
Flisiak R, Feinman S V, Jablkowski M, et al. 2009. The cyclophilin inhibitor Debio 025 combined with PEG IFNalpha2a significantly reduces viral load in treatment-naive hepatitis C patients. Hepatology, 49: 1460-1468.
doi: 10.1002/hep.22835
-
Flisiak R, Feinman S V, Jablkowski M, et al. 2009. The cyclophilin inhibitor Debio 025 combined with PEG IFNalpha2a significantly reduces viral load in treatment-naive hepatitis C patients. Hepatology, 49: 1460-1468.
doi: 10.1002/hep.22835
-
Flisiak R, Horban A, Gallay P, et al. 2008. The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus. Hepatology, 47: 817-826.
doi: 10.1002/hep.22131
-
Forestier N, Reesink H W, Weegink C J, et al. 2007. Antiviral activity of telaprevir (VX-950) and peginterferon alfa-2a in patients with hepatitis C. Hepatology, 46: 640-648.
doi: 10.1002/hep.v46:3
-
Fried M, Shiffman M L, Reddy K R, et al. 2002. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med, 347: 975-982.
doi: 10.1056/NEJMoa020047
-
Gaither L A, Borawski J, Anderson L J, et al. 2010. Multiple cyclophilins involved in different cellular pathways mediate HCV replication. Virology, 397: 43-55.
doi: 10.1016/j.virol.2009.10.043
-
Gane E J, Oberts S K, Tedman C, et al. 2009. First-in-man demonstration of potent antiviral activity with a nucleoside polymerase (R7128) and protease (R7227/ITMN-191) inhibitor combination in HCV: safety, pharmacokinetics, and virologic results from INFORM-1. J Hepatol, 50 (Suppl.1): S380 (Abstract 1046).
-
Gane E J, Roberts S K, Stedman C, et al. 2009. First-in-man demonstration of potent antiviral activity with a nucleoside polymerase (R7128) and protease (R7227/ITMN-191) inhibitor combination in HCV: Safety, pharmacokinetics, and virologic results from INFORM-1. 44th Annual Meeting of the European Association for the Study of the Liver. Copenhagen, Denmark.
-
Goto K, Watashi K, Inoue D, et al. 2009. Identification of cellular and viral factors related to anti-hepatitis C virus activity of cyclophilin inhibitor. Cancer Sci, 100: 1943-1950.
doi: 10.1111/cas.2009.100.issue-10
-
Gozdek A, Zhukov I, Polkowska A, et al. 2008. NS3 Peptide, a novel potent hepatitis C virus NS3 helicase inhibitor: its mechanism of action and antiviral activity in the replicon system. Antimicrob Agents Chemother, 52: 393-401.
doi: 10.1128/AAC.00961-07
-
Grakoui A, McCourt D W, Wychowski C, et al. 1993. A second hepatitis C virus-encoded proteinase. Proc Natl Acad Sci USA, 90: 10583-10587.
doi: 10.1073/pnas.90.22.10583
-
Griffin S, StGelais C, Owsianka A M, et al. 2008. Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel. Hepatology, 48: 1779-1790.
doi: 10.1002/hep.22555
-
Griffin S D, Beales L P, Clarke D S, et al. 2003. The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine. FEBS Lett, 535: 34-38.
doi: 10.1016/S0014-5793(02)03851-6
-
Habersetzer F, Baumert T F, Stoll-Keller F. 2009. GI-5005, a yeast vector vaccine expressing an NS3-core fusion protein for chronic HCV infection. Curr Opin Mol Ther, 11: 456-462.
-
Hanoulle X, Badillo A, Wieruszeski J M, et al. 2009. Hepatitis C virus NS5A protein is a substrate for the Peptidyl-Prolyl cis/trans isomerase activity of Cyclophilins A and B. J Biol Chem, 284 (20): 13589-13601.
doi: 10.1074/jbc.M809244200
-
Heck J A, Meng X, Frick D N. 2009. Cyclophilin B stimulates RNA synthesis by the HCV RNA dependent RNA polymerase. Biochem Pharmacol, 77: 1173-1180.
doi: 10.1016/j.bcp.2008.12.019
-
Hendricks R T, Fell J B, Blake J F, et al. 2009. Non-nucleoside inhibitors of HCV NS5B polymerase. Part 1: Synthetic and computational exploration of the binding modes of benzothiadiazine and 1, 4-benzothiazine HCV NS5b polymerase inhibitors. Bioorg Med Chem Lett, 19: 3637-3641.
doi: 10.1016/j.bmcl.2009.04.119
-
Hezode C, Forestier N, Dusheiko G, et al. 2009. Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. N Engl J Med, 360: 1839-1850.
doi: 10.1056/NEJMoa0807650
-
Hinrichsen H, Benhamou Y, Wedemeyer H, et al. 2004. Short-term antiviral efficacy of BILN 2061, a hepatitis C virus serine protease inhibitor, in hepatitis C genotype 1 patients. Gastroenterology, 127: 1347-1355.
doi: 10.1053/j.gastro.2004.08.002
-
Hopkins S, Heuman D, Gavis E, et al. 2009. Safety, plasma pharmacokinetics, and anti-viral activity of SCY-635 in adult patients with chronic hepatitis C virus infection. J Hepatol, 50 (Suppl.1): S36 (Abstract 89).
-
Hopkins S, Scorneaux B, Huang Z, et al. 2010. SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro. Antimicrob Agents Chemother, 54: 660-672.
doi: 10.1128/AAC.00660-09
-
Horsmans Y, Berg T, Desager J P, et al. 2005. Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection. Hepatology, 42: 724-731.
doi: 10.1002/(ISSN)1527-3350
-
Howe A Y, Cheng H, Johann S, et al. 2008. Molecular mechanism of hepatitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, HCV-796. Antimicrob Agents Chemother, 52: 3327-3338.
doi: 10.1128/AAC.00238-08
-
Hsu M, Zhang J, Flint M, et al. 2003. Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles. Proc Natl Acad Sci USA, 100: 7271-7276.
doi: 10.1073/pnas.0832180100
-
Jirasko V, Montserret R, Appel N, et al. 2008. Structural and functional characterization of nonstructural protein 2 for its role in hepatitis C virus assembly. J Biol Chem, 283: 28546-28562.
doi: 10.1074/jbc.M803981200
-
Jones C T, Murray C L, Eastman D K, et al. 2007. Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus. J Virol, 81: 8374-8383.
doi: 10.1128/JVI.00690-07
-
Kaita K, Yoshida E, Kunimoto D, et al. 2007. Ph Ⅱ proof of concept study of celgosivir in combination with peginterferon alfa-2b and ribavirin in chronic hepatitis C genotype 1 non-responder patients. J Hepatol, 46 (Suppl. 1): S56 (A127).
-
Kaul A, Stauffer S, Berger C, et al. 2009. Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. PLoS Pathog, 5 (8): e1000546.
doi: 10.1371/journal.ppat.1000546
-
Khoury G, Ewart G, Luscombe C, et al. 2010. Antiviral efficacy of the novel compound BIT225 against HIV-1 release from human macrophages. Antimicrob Agents Chemother, 54: 835-845.
doi: 10.1128/AAC.01308-09
-
Kim J L, Morgenstern K A, Lin C, et al. 1996. Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide. Cell, 87: 343-355.
doi: 10.1016/S0092-8674(00)81351-3
-
Klade C S, Wedemeyer H, Berg T, et al. 2008. Therapeutic vaccination of chronic hepatitis C nonresponder patients with the peptide vaccine IC41. Gastroenterology, 134: 1385-1395.
doi: 10.1053/j.gastro.2008.02.058
-
Korba B E, Montero A B, Farrar K, et al. 2008. Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication. Antiviral Res, 77: 56-63.
doi: 10.1016/j.antiviral.2007.08.005
-
Kwo P, Lawitz E, McCone J, et al. 2009. HCV SPRINT-1 final results: SVR 24 from a phase 2 study of boceprevir plus Pegintron™ (peginterferon alfa-2b)/ ribavirin in treatment-naive subjects with genotype-1 chronic hepatitis C. J Hepatol, 50 (Suppl.1): S4 (Abstract 4).
-
Lalezari J, Asmuth D, Casiro A, et al. 2009. Antiviral activity, safety and pharmacokinetics of IDX184, a liver-targeted nucleotide HCV polymerase inhibitor, in patients with chronic hepatitis C. 60th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, MA.
-
Lamarre D, Anderson P C, Bailey M, et al. 2003. An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus. Nature, 426: 186-189.
doi: 10.1038/nature02099
-
Landro J A, Raybuck S A, Luong Y P, et al. 1997. Mechanistic role of an NS4A peptide cofactor with the truncated NS3 protease of hepatitis C virus: elucidation of the NS4A stimulatory effect via kinetic analysis and inhibitor mapping. Biochemistry, 36: 9340-9348.
doi: 10.1021/bi963054n
-
Larrey D, Benhamou Y, Lohse A W, et al. 2010. Safety, pharmacokinetics and antiviral effect of BI 207127, a novel HCV RNA polymerase inhibitor, after 5 days oral treatment in patients with chronic hepatitis C. J Hepatol, 50 (Suppl.1): S383-S4 (Abstract 1054).
-
Lawitz E, Rouzier R, Nguyen, et al. 2009. Safety and antiviral efficacy of 14 days of the cyclophilin inhibitor NIM811 in combination with pegylated interferon α2A in relapsed genotype 1 HCV infected patients. 44th Annual Meeting of the European Association for the Study of the Liver. Boston, MA.
-
Lawitz E, Cooper C, Rodriguez-Torres M, et al. 2009. Safety, tolerability and antiviral activity of VCH-916, a novel non-nucleoside hcv polymerase inhibitor in patients with chronic HCV genotype-1 infection. J Hepatol, 50 (Suppl.1): S37 (Abstract 92).
-
Lawitz E, Rodriguez-Torres M, DeMicco M, et al. 2009. Antiviral activity of ANA598, a potent non-nucleoside polymerase inhibitor, in chronic hepatitis C patients. J Hepatol, 50 (Suppl.1): S384 (Abstract 1055).
-
Lemm J A, O'Boyle D, Liu M, et al. 2010. Identification of hepatitis C virus NS5A inhibitors. J Virol, 84: 482-491.
doi: 10.1128/JVI.01360-09
-
Lesburg C A, Cable M B, Ferrari E, et al. 1999. Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site. Nat Struct Biol, 6: 937-943.
doi: 10.1038/13305
-
Li Q, Brass A L, Ng A, et al. 2009. A genome-wide genetic screen for host factors required for hepatitis C virus propagation. Proc Natl Acad Sci USA, 106: 16410-16415.
doi: 10.1073/pnas.0907439106
-
Lin K, Perni R B, Kwong A D, et al. 2006. VX-950, a novel hepatitis C virus (HCV) NS3-4A protease inhibitor, exhibits potent antiviral activities in HCv replicon cells. Antimicrob Agents Chemother, 50: 1813-1822.
doi: 10.1128/AAC.50.5.1813-1822.2006
-
Lin T I, Lenz O, Fanning G, et al. 2009. In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor. Antimicrob Agents Chemother, 53: 1377-1385.
doi: 10.1128/AAC.01058-08
-
Lindenbach B D, Evans M J, Syder A J, et al. 2005. Complete replication of hepatitis C virus in cell culture. Science, 309: 623-626.
doi: 10.1126/science.1114016
-
Liu Z, Yang F, Robotham J M, et al. 2009. A Critical Role of Cyclophilin A and its Prolyl-Peptidyl Isomerase Activity in the Structure and Function of the HCV Replication Complex. J Virol, doi: JVI.02550-08
-
Liverton N J, Carroll S S, Dimuzio J, et al. 2010. MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease. Antimicrob Agents Chemother, 54: 305-311.
doi: 10.1128/AAC.00677-09
-
Llinas-Brunet M, Bailey M, Fazal G, et al. 1998. Peptide-based inhibitors of the hepatitis C virus serine protease. Bioorg Med Chem Lett, 8: 1713-1718.
doi: 10.1016/S0960-894X(98)00299-6
-
Lohmann V, Korner F, Koch J, et al. 1999. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science, 285: 110-113.
doi: 10.1126/science.285.5424.110
-
Love R A, Brodsky O, Hickey M J, et al. 2009. Crystal structure of a novel dimeric form of NS5A domain Ⅰ protein from hepatitis C virus. J Virol, 83: 4395-4403.
doi: 10.1128/JVI.02352-08
-
Love R A, Parge H E, Wickersham J A, et al. 1996. The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site. Cell, 87: 331-342.
doi: 10.1016/S0092-8674(00)81350-1
-
Luik P, Chew C, Aittoniemi J, et al. 2009. The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy. Proc Natl Acad Sci USA, 106: 12712-12716.
doi: 10.1073/pnas.0905966106
-
Luscombe C A, Huang Z, Murray M G, et al. 2010. A novel Hepatitis C virus p7 ion channel inhibitor, BIT225, inhibits bovine viral diarrhea virus in vitro and shows synergism with recombinant interferon-alpha-2b and nucleoside analogues. Antiviral Res, doi:S0166-3542 (10) 00341-00344.
-
Ma S, Boerner J E, TiongYip C, et al. 2006. NIM811, a cyclophilin inhibitor, exhibits potent in vitro activity against hepatitis C virus alone or in combination with alpha interferon. Antimicrob Agents Chemother, 50: 2976-2982.
doi: 10.1128/AAC.00310-06
-
Malcolm B A, Liu R, Lahser F, et al. 2006. SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells. Antimicrob Agents Chemother, 50: 1013-1020.
doi: 10.1128/AAC.50.3.1013-1020.2006
-
Manns M, Bourliere M, Benhamou Y, et al. 2008. Safety and antiviral activity of BI201335, a new HCV NS3 protease inhibitor, in combination therapy with peginterferon alfa 2a (P) and ribavirin (R) for 28 days in P+R treatment-experienced patients with chronic hepatitis C genotype-1 infection. Hepatology, 48(Suppl.1): 1151A (Abstract 882).
-
Manns M, Bourliere M, Benhamou Y, et al. 2008. Safety and antiviral activity of BI201335, a new HCV NS3 protease inhibitor, in treatment-naive patients with chronic hepatitis C genotype 1 infection given as monotherapy and in combination with peginterferon alfa-2a (P) and ribavirin (R). Hepatology, 48 (Suppl.1): 1133A (Abstract 849).
-
Manns M, Muir A, Adda N, et al. 2009. Telaprevir in hepatitis C genotype-1-infected patients with prior non-response, viral breakthrough or relapse to peginterferon-alfa-2a/b and ribavirin therapy: SVR results of the PROVE 3 study. J Hepatol, 50 (Supp.1): S379 (Abstract 1044).
-
Manns M P, McHutchison J G, Gordon S C, et al. 2001. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet, 358: 958-965.
doi: 10.1016/S0140-6736(01)06102-5
-
Mathy J E, Ma S, Compton T, et al. 2008. Com-binations of cyclophilin inhibitor NIM811 with hepatitis C Virus NS3-4A Protease or NS5B polymerase inhibitors enhance antiviral activity and suppress the emergence of resistance. Antimicrob Agents Chemother, 52: 3267-3275.
doi: 10.1128/AAC.00498-08
-
McCown M F, Rajyaguru S, Le P S, et al. 2008. The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleoside polymerase or protease inhibitors. Antimicrob Agents Chemother, 52: 1604-1612.
doi: 10.1128/AAC.01317-07
-
McHutchison J G, Everson G T, Gordon S C, et al. 2009. Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection. N Engl J Med, 360: 1827-1838.
doi: 10.1056/NEJMoa0806104
-
Mercer D F, Schiller D E, Elliott J F, et al. 2001. Hepatitis C virus replication in mice with chimeric human livers. Nat.Med, 7: 927-933.
doi: 10.1038/90968
-
Nakagawa M, Sakamoto N, Enomoto N, et al. 2004. Specific inhibition of hepatitis C virus replication by cyclosporin A. Biochem Biophys Res Commun, 313 (1), 42-47.
doi: 10.1016/j.bbrc.2003.11.080
-
Nakagawa M, Sakamoto N, Tanabe Y, et al. 2005. Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilins. Gastroenterology, 129: 1031-1041.
doi: 10.1053/j.gastro.2005.06.031
-
Nelson D R, Rustgi V, Balan V, et al. 2009. Safety and antiviral activity of albinterferon alfa-2b in prior interferon nonresponders with chronic hepatitis C. Clin Gastroenterol Hepatol, 7: 212-218.
doi: 10.1016/j.cgh.2008.10.035
-
Nettles R, Chien C, Chung E, et al. 2008. BMS-790052 is a first-in-class potent hepatitis C virus (HCV) NS5A inhibitor for patients with chronic HCV infection: results from a proof-of-concept study. Hepatology, 48 (Suppl.1): 1025A (Abstract LB12).
-
Neumann A U, Lam N P, Dahari H, et al. 1998. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy. Science, 282: 103-107.
doi: 10.1126/science.282.5386.103
-
Ng T I, Mo H, Pilot-Matias T, et al. 2007. Identification of host genes involved in hepatitis C virus replication by small interfering RNA technology. Hepatology, 45: 1413-1421.
doi: 10.1002/(ISSN)1527-3350
-
Nguyen T T, Gates A T, Gutshall L L, et al. 2003. Resistance profile of a hepatitis C virus RNA-dependent RNA polymerase benzothiadiazine inhibitor. Antimicrob Agents Chemother, 47: 3525-3530.
doi: 10.1128/AAC.47.11.3525-3530.2003
-
Paeshuyse J, Kaul A, De C E, et al. 2006. The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro. Hepatology, 43: 761-770.
doi: 10.1002/(ISSN)1527-3350
-
Paeshuyse J, Kaul A, De C E, et al. 2006. The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro. Hepatology, 43: 761-770.
doi: 10.1002/(ISSN)1527-3350
-
Pasquinelli C. et al. 2009. Safety, tolerability, pharmacokinetics and antiviral activity following single-and multiple-dose administration of BMS-650032, a novel HCV NS3 inhibitor, in subjects with chronic genotype 1HCV infection. 60th annual meeting of the American Association for the Study of Liver Diseases (AASLD), Boston, USA.
-
Pavlovic D, Neville D C, Argaud O, et al. 2003. The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives. Proc Natl Acad Sci USA, 100: 6104-6108.
doi: 10.1073/pnas.1031527100
-
Perni R B, Almquist S J, Byrn R A, et al. 2006. Preclinical profile of VX-950, a potent, selective, and orally bioavailable inhibitor of hepatitis C virus NS3-4A serine protease. Antimicrob.Agents Chemother, 50: 899-909.
doi: 10.1128/AAC.50.3.899-909.2006
-
Pierra C, Amador A, Benzaria S, et al. 2006. Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine. J Med Chem, 49: 6614-6620.
doi: 10.1021/jm0603623
-
Pileri P, Uematsu Y, Campagnoli S, et al. 1998. Binding of hepatitis C virus to CD81. Science, 282: 938-941.
doi: 10.1126/science.282.5390.938
-
Ploss A, Evans M J, Gaysinskaya V A, et al. 2009. Human occludin is a hepatitis C virus entry factor required for infection of mouse cells. Nature, 457: 882-886.
doi: 10.1038/nature07684
-
Pockros P J, Nelson D, Godofsky E, et al. 2008. R1626 plus peginterferon Alfa-2a provides potent suppression of hepatitis C virus RNA and significant antiviral synergy in combination with ribavirin. Hepatology, 48: 385-397.
doi: 10.1002/hep.v48:2
-
Premkumar A, Wilson L, Ewart G D, et al. 2004. Cation-selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride. FEBS Lett, 557: 99-103.
doi: 10.1016/S0014-5793(03)01453-4
-
Puyang X, Poulin D L, Mathy J E, et al. 2010. Mechanism of Resistance of HCV Replicons to Structurally Distinct Cyclophilin Inhibitors. Antimicrob. Agents Chemother, doi: AAC.01236-09.
-
Randolph J T, Flentge C A, Huang P P, et al. 2009. Synthesis and biological characterization of B-ring amino analogues of potent benzothiadiazine hepatitis C virus polymerase inhibitors. J Med Chem, 52: 3174-3183.
doi: 10.1021/jm801485z
-
Reesink H W, Fanning G C, Farha K A, et al. 2010. Rapid HCV-RNA decline with once daily TMC435: a phase Ⅰ study in healthy volunteers and hepatitis C patients. Gastroenterology, 138: 913-921.
doi: 10.1053/j.gastro.2009.10.033
-
Reesink H W, Zeuzem S, Weegink C J, et al. 2006. Rapid decline of viral RNA in hepatitis C patients treated with VX-950: a phase Ib, placebo-controlled, randomized study. Gastroenterology, 131: 997-1002.
doi: 10.1053/j.gastro.2006.07.013
-
Reiser M, Hinrichsen H, Benhamou Y, et al. 2005. Antiviral efficacy of NS3-serine protease inhibitor BILN-2061 in patients with chronic genotype 2 and 3 hepatitis C. Hepatology, 41: 832-835.
doi: 10.1002/(ISSN)1527-3350
-
Roberts C D. 2008. Targeting HCV NS4b Function: A New Approach to Anti-HCV Activity. Inaugural HCV Drug Discovery meeting, San Diego, CA.
-
Roberts S K, Cooksley G, Dore G J, et al. 2008. Robust antiviral activity of R1626, a novel nucleoside analog: a randomized, placebo-controlled study in patients with chronic hepatitis C. Hepatology, 48: 398-406.
doi: 10.1002/hep.v48:2
-
Robida J M, Nelson H B, Liu Z, et al. 2007. Characterization of hepatitis C virus subgenomic replicon resistance to cyclosporine in vitro. J Virol, 81: 5829-5840.
doi: 10.1128/JVI.02524-06
-
Rodriguez-Torres M, Lalezari J, Gane E J, et al. 2008. Potent antiviral response to the HCV nucleoside polymerase inhibitor R7128 for 28 days with peg-IFN and ribavirin: subanalysis by race/ethnicity, weight, and HCV genotype. Hepatology, 48 (Suppl.1): 1160A (Abstract 899).
-
Rodriguez-Torres M, Lawitz E, Flach S, et al. 2009. Antiviral activity, pharmacokinetics, safety, and tolerability of PSI-7851, a novel nucleotide polymerase inhibitor for HCV, following single and 3 Day multiple ascending oral doses in healthy volunteers and patients with chronic HCV infection. 60th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, MA.
-
Rodriguez-Torres M, Lawitz E, Conway B, et al. 2010. Safety and antiviral activity of the HCV non-nucleoside polymerase inhibitor VX-222 in treatment-na ve genotype 1 HCV-infected patients. 45th Annual Meeting of the European Association for the Study of the Liver (EASL) in Vienna, Austria,
-
Rossignol J F, Kabil S M, El-Gohary Y, et al. 2008. Clinical trial: randomized, double-blind, placebo-controlled study of nitazoxanide monotherapy for the treatment of patients with chronic hepatitis C genotype 4. Aliment Pharmacol Ther, 28: 574-580.
doi: 10.1111/apt.2008.28.issue-5
-
Sakai A, Claire M S, Faulk K, et al. 2003. The p7 polypeptide of hepatitis C virus is critical for infectivity and contains functionally important genotype-specific sequences. Proc Natl Acad Sci USA, 100: 11646-11651.
doi: 10.1073/pnas.1834545100
-
Sarrazin C, Rouzier R, Wagner F, et al. 2007. SCH 503034, a novel hepatitis C virus protease inhibitor, plus pegylated interferon alpha-2b for genotype 1 nonresponders. Gastroenterology, 132: 1270-1278.
doi: 10.1053/j.gastro.2007.01.041
-
Sarrazin C and Zeuzem S. 2010. Resistance to direct antiviral agents in patients with hepatitis C virus infection. Gastroenterology, 138: 447-462.
doi: 10.1053/j.gastro.2009.11.055
-
Scarselli E, Ansuini H, Cerino R, et al. 2002. The human scavenger receptor class B type Ⅰ is a novel candidate receptor for the hepatitis C virus. EMBO J, 21: 5017-5025.
doi: 10.1093/emboj/cdf529
-
Seiwert S D, Andrews S W, Jiang Y, et al. 2008. Preclinical characteristics of the hepatitis C virus NS3/4A protease inhibitor ITMN-191 (R7227). Antimicrob. Agents Chemother, 52: 4432-4441.
doi: 10.1128/AAC.00699-08
-
Shaw A N, Tedesco R, Bambal R, et al. 2009. Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase. Bioorg Med Chem Lett, 19: 4350-4353.
doi: 10.1016/j.bmcl.2009.05.091
-
Sheaffer A K, Lee M S, Chaniewski S, et al. 2008. Resistance to a novel HCV replication inhibitor maps to amino acid changes within the NS4B Sequence. 15th International Symposium on Hepatitis C and Related Viruses, San Antonio, Texas.
-
Shi S T, Herlihy K J, Graham J P, et al. 2009. Preclinical characterization of PF-00868554, a potent nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase. Antimicrob Agents Chemother, 53: 2544-2552.
doi: 10.1128/AAC.01599-08
-
Stankiewicz-Drogon A, Palchykovska L G, Kostina V G, et al. 2008. New acridone-4-carboxylic acid derivatives as potential inhibitors of hepatitis C virus infection. Bioorg Med Chem, 16: 8846-8852.
doi: 10.1016/j.bmc.2008.08.074
-
Steinkuhler C, Biasiol G, Brunetti M, et al. 1998. Product inhibition of the hepatitis C virus NS3 protease. Biochemistry, 37: 8899-8905.
doi: 10.1021/bi980313v
-
Steinmann E, Penin F, Kallis S, et al. 2007. Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions. PLoS Pathog, 3: e103.
doi: 10.1371/journal.ppat.0030103
-
Steinmann E, Whitfield T, Kallis S, et al. 2007. Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus. Hepatology, 46: 330-338.
-
Taliani M, Bianchi E, Narjes F, et al. 1996. A continuous assay of hepatitis C virus protease based on resonance energy transfer depsipeptide substrates. Anal Biochem, 240: 60-67.
doi: 10.1006/abio.1996.0331
-
Tellinghuisen T L, Marcotrigiano J, Rice C M. 2005. Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase. Nature, 435: 374-379.
doi: 10.1038/nature03580
-
Thibeault D, Maurice R, Pilote L, et al. 2001. In vitro characterization of a purified NS2/3 protease variant of hepatitis C virus. J Biol Chem, 276: 46678-46684.
doi: 10.1074/jbc.M108266200
-
Tomei L, Failla C, Santolini E, et al. 1993. NS3 is a serine protease required for processing of hepatitis C virus polyprotein. J Virol. 67: 4017-4026.
-
Ujjinamatada R K, Baier A, Borowski P, et al. 2007. An analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: synthesis and in vitro screening of 4-carbamoyl-5-(4, 6-diamino-2, 5-dihydro-1, 3, 5-triazin-2-yl) imidazole-1-beta-D-ribofura-noside. Bioorg Med Chem Lett, 17: 2285-2288.
doi: 10.1016/j.bmcl.2007.01.074
-
Vaillancourt F H, Pilote L, Cartier M, et al. 2009. Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replication. Virology, 387: 5-10.
doi: 10.1016/j.virol.2009.02.039
-
Wakita T, Pietschmann T, Kato T, et al. 2005. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med, 11: 791-796.
doi: 10.1038/nm1268
-
Watashi K, Hijikata M, Hosaka M, et al. 2003. Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes. Hepatology, 38: 1282-1288.
doi: 10.1053/jhep.2003.50449
-
Watashi K, Ishii N, Hijikata M, et al. 2005. Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase. Mol Cell, 19: 111-122.
doi: 10.1016/j.molcel.2005.05.014
-
Wedemeyer H, Schuller E, Schlaphoff V, et al. 2009. Therapeutic vaccine IC41 as late add-on to standard treatment in patients with chronic hepatitis C. Vaccine, 27: 5142-5151.
doi: 10.1016/j.vaccine.2009.06.027
-
Welbourn S, Green R, Gamache I, et al. 2005. Hepatitis C virus NS2/3 processing is required for NS3 stability and viral RNA replication. J Biol Chem, 280: 29604-29611.
doi: 10.1074/jbc.M505019200
-
Whitby K, Taylor D, Patel D, et al. 2004. Action of celgosivir (6 O-butanoyl castanospermine) against the pestivirus BVDV: implications for the treatment of hepatitis C. Antivir Chem Chemother, 15: 141-151.
doi: 10.1177/095632020401500304
-
Xiang A X, Webber S E, Kerr B M, et al. 2007. Discovery of ANA975: an oral prodrug of the TLR-7 agonist isatoribine. Nucleosides Nucleotides Nucleic Acids, 26: 635-640.
doi: 10.1080/15257770701490472
-
Xue Q, Ding H, Liu M, et al. 2007. Inhibition of hepatitis C virus replication and expression by small interfering RNA targeting host cellular genes. Arch Virol, 152: 955-962.
doi: 10.1007/s00705-006-0905-x
-
Yang F, Robotham J M, Nelson H B, et al. 2008. Cyclophilin A is an essential cofactor for hepatitis C virus infection and the principal mediator of cyclosporine resistance in vitro. J Virol, 82:5269-5278.
doi: 10.1128/JVI.02614-07
-
Yang W, Zhao Y, Fabrycki J, et al. 2008. Selection of replicon variants resistant to ACH-806, a novel hepatitis C virus inhibitor with no cross-resistance to NS3 protease and NS5B polymerase inhibitors. Antimicrob. Agents Chemother, 52: 2043-2052.
doi: 10.1128/AAC.01548-07
-
Yi M, Villanueva R A, Thomas D L, et al. 2006. Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells. Proc Natl Acad Sci USA, 103: 2310-2315.
doi: 10.1073/pnas.0510727103
-
Yoshida E, Kunimoto D, Lee S S, et al. 2006. Results of a phase 2 dose ranging study of orally administered celgosivir as monotherapy in chronic hepatitis C genotype 1 patients. Gastroenterology, 130: A784.
-
Zeuzem S, Yoshida E M, Benhamou Y, et al. 2008. Albinterferon alfa-2b dosed every two or four weeks in interferon-naive patients with genotype 1 chronic hepatitis C. Hepatology, 48: 407-417.
-
Zhong J, Gastaminza P, Cheng G, et al. 2005. Robust hepatitis C virus infection in vitro. Proc Natl Acad Sci USA, 102: 9294-9299.
doi: 10.1073/pnas.0503596102