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Volume 28 Issue 4
August 2013
    Citation: Yi Hu, Jingxin Zhang. Screening Strategies to Identify Host Factors Associated with the Early and Late Stages of HIV-1 Life Cycle .VIROLOGICA SINICA, 2013, 28(4) : 242-245.  http://dx.doi.org/10.1007/s12250-013-3359-9
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    Screening Strategies to Identify Host Factors Associated with the Early and Late Stages of HIV-1 Life Cycle

    • 1.

      CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, China

    • 2.

      Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

    • Corresponding author: Jingxin Zhang, zhang_jingxin@hotmail.com
    • Received Date: 04 July 2013
      Accepted Date: 25 July 2013
      Published Date: 26 July 2013
      Available online: 01 August 2013
    • The HIV-1 infection in humans has now become a pandemic and in the absence of treatment it often leads to acquired immunodeficiency syndrome (AIDS). Although significant progress has been made to reduce the HIV-1 viral load in the blood of infected patients, challenges still exist in areas such as viral latency and viral resistance (Hosseinipour M C, 2013; Katlama C, 2013).
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      1. Brass A L, Dykxhoorn D M, Benita Y, Yan N, Engelman A, Xavier R J, Lieberman J, Elledge S J. 2008. Identification of host proteins required for HIV infection through a functional genomic screen. Science, 319:921-926.
          doi: 10.1126/science.1152725

      2. Das A T, Baldwin C E, Vink M, Berkhout B. 2005. Improving the safety of a conditional-live human immunodeficiency virus type 1 vaccine by controlling both gene expression and cell entry. J Virol, 79:3855-3858.
          doi: 10.1128/JVI.79.6.3855-3858.2005

      3. Das A T, Klaver B, Harwig A, Vink M, Ooms M, Centlivre M, Berkhout B. 2007. Construction of a doxycycline-dependent simian immunodeficiency virus reveals a nontranscriptional function of tat in viral replication. J Virol, 81:11159-11169.
          doi: 10.1128/JVI.01354-07

      4. Garrus J E, von Schwedler U K, Pornillos O W, Morham S G, Zavitz K H, Wang H E, Wettstein D A, Stray K M, Côté M, Rich R L, Myszka D G, Sundquist W I. 2001. Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. Cell, 107:55-65.
          doi: 10.1016/S0092-8674(01)00506-2

      5. Hosseinipour M C, Gupta R K, Van Zyl G, Eron J J, Nachega J B. 2013. Emergence of HIV drug resistance during first-and second-line antiretroviral therapy in resource-limited settings. J Infect Dis, 207 Suppl 2:S49-56.

      6. Katlama C, Deeks S G, Autran B, Martinez-Picado J, van Lunzen J, Rouzioux C, Miller M, Vella S, Schmitz J E, Ahlers J, Richman D D, Sekaly R P. 2013. Barriers to a cure for HIV:new ways to target and eradicate HIV-1 reservoirs. Lancet, 381:2109-2117.
          doi: 10.1016/S0140-6736(13)60104-X

      7. Platt E J, Bilska M, Kozak S L, Kabat D, Montefiori D C. 2009. Evidence that ecotropic murine leukemia virus contamination in TZM-bl cells does not affect the outcome of neutralizing antibody assays with human immunodeficiency virus type 1. J Viro, 83:8289-8292.
          doi: 10.1128/JVI.00709-09

      8. Sadaie M R, Benter T, Wong-Staal F. 1988. Site-directed mutagenesis of two trans-regulatory genes (tat-Ⅲ, trs) of HIV-1. Science, 239:910-913.
          doi: 10.1126/science.3277284

      9. Shirakawa K, Chavez L, Hakre S, Calvanese V, Verdin E. 2013. Reactivation of latent HIV by histone deacetylase inhibitors. Trends Microbiol, 21:277-285.
          doi: 10.1016/j.tim.2013.02.005

      10. Walker B D, Yu X G. 2013. Unravelling the mechanisms of durable control of HIV-1. Nat Rev Immunol, 13:487-498.
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      11. Wei P, Garber M E, Fang S M, Fischer W H, Jones K A. 1998. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. Cell, 92:451-462.
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      12. Zhang J X, Diehl G E, Littman D R. 2008. Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells. PLoS One, 3:e2035.
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      13. Zhou H, Xu M, Huang Q, Gates A T, Zhang X D, Castle J C, Stec E, Ferrer M, Strulovici B, Hazuda D J, Espeseth A S. 2008. Genome-scale RNAi screen for host factors required for HIV replication. Cell Host Microbe, 4:495-504.
          doi: 10.1016/j.chom.2008.10.004

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      Screening Strategies to Identify Host Factors Associated with the Early and Late Stages of HIV-1 Life Cycle

        Corresponding author: Jingxin Zhang, zhang_jingxin@hotmail.com
      • 1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, China
      • 2. Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
      • Received Date: 04 July 2013
      • Accepted Date: 25 July 2013
      • Published Date: 26 July 2013

      Abstract: The HIV-1 infection in humans has now become a pandemic and in the absence of treatment it often leads to acquired immunodeficiency syndrome (AIDS). Although significant progress has been made to reduce the HIV-1 viral load in the blood of infected patients, challenges still exist in areas such as viral latency and viral resistance (Hosseinipour M C, 2013; Katlama C, 2013).

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