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Volume 31 Issue 4
August 2016
    Citation: Hui Ding, Wuritu Yang, Hua Tang, Peng-Mian Feng, Jian Huang, Wei Chen, Hao Lin. PHYPred: a tool for identifying bacteriophage enzymes and hydrolases .VIROLOGICA SINICA, 2016, 31(4) : 350-352.  http://dx.doi.org/10.1007/s12250-016-3740-6
    shu

    PHYPred: a tool for identifying bacteriophage enzymes and hydrolases

    cstr: 32224.14.s12250-016-3740-6
    • 1.

      Key Laboratory for Neuro-Information of Ministry of Education, Center of Bioinformatics, School of Life Science and Technology and Center for Information in Biomedicine, University of Electronic Science and Technology of China, Chengdu 610054, China

    • 2.

      Graduate Affairs Department, Inner Mongolia University, Hohhot 010021, China

    • 3.

      Department of Pathophysiology, Southwest Medical University, Luzhou 646000, China

    • 4.

      School of Public Health, North China University of Science and Technology, Tangshan 063000, China

    • 5.

      Department of Physics, School of Sciences, Center for Genomics and Computational Biology, North China University of Science and Technology, Tangshan 063009, China

    • Bacteriophages are viruses that attack bacteria and kill them through the lytic replication cycle. Many studies have reported that phages are more specific to bacteria than antibiotics are; thus, phage therapy has many potential applications in human medicine, with the advantage of having few side effects (Keen, 2012). Investigating the mechanisms of bacteria-killing phages will therefore aid in the development of antibacterial drugs.
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      1. Ding H, Feng PM, Chen W, et al. 2014. Mol Biosyst, 10: 2229-2235.
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      2. Feng PM, Ding H, Chen W, et al. 2013. Comput Math Methods Med, 530696.

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      6. Lin H, Chen W, Ding H. 2013. PLoS One, 8: e75726.
          doi: 10.1371/journal.pone.0075726

      7. Lin H, Ding H, Guo FB, et al. 2008. Protein Pept Lett, 15, 739-744.
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      8. Lin H, Deng EZ, Ding H, et al. 2014. Nucleic Acids Res, 42: 12961-12972.
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      9. Liu B, Fang L, Long R, et al. 2015. Bioinformatics, 32: 362-369.

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      11. Seguritan V, Alves N Jr, Arnoult M, et al. 2012. PLoS Comput Biol, 8: e1002657.
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      12. Tang H, Chen W, Lin H. 2016. Mol Biosyst, 12: 1269-1275.
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      13. UniProt C. 2015. Nucleic Acids Res, 43: D204-D212.
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      14. Zhu PP, Li WC, Zhong ZJ, et al. 2015. Mol Biosyst, 11: 558-563.
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      15. Zou Q, Li XB, Jiang Y, et al. 2013. Curr Proteomics, 10: 2-9.
          doi: 10.2174/1570164611310010002

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      PHYPred: a tool for identifying bacteriophage enzymes and hydrolases

        Corresponding author: Wei Chen, greatchen@heuu.edu.cn
        Corresponding author: Hao Lin, hlin@uestc.edu.cn
      • 1. Key Laboratory for Neuro-Information of Ministry of Education, Center of Bioinformatics, School of Life Science and Technology and Center for Information in Biomedicine, University of Electronic Science and Technology of China, Chengdu 610054, China
      • 2. Graduate Affairs Department, Inner Mongolia University, Hohhot 010021, China
      • 3. Department of Pathophysiology, Southwest Medical University, Luzhou 646000, China
      • 4. School of Public Health, North China University of Science and Technology, Tangshan 063000, China
      • 5. Department of Physics, School of Sciences, Center for Genomics and Computational Biology, North China University of Science and Technology, Tangshan 063009, China
      • Published Date: 04 March 2016

      Abstract: Bacteriophages are viruses that attack bacteria and kill them through the lytic replication cycle. Many studies have reported that phages are more specific to bacteria than antibiotics are; thus, phage therapy has many potential applications in human medicine, with the advantage of having few side effects (Keen, 2012). Investigating the mechanisms of bacteria-killing phages will therefore aid in the development of antibacterial drugs.

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