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Volume 31 Issue 4
August 2016
    Citation: Yuhai Bi, Jianjun Chen, Zhenjie Zhang, Mingxin Li, Tianlong Cai, Kirill Sharshov, Ivan Susloparov, Alexander Shestopalov, Gary Wong, Yubang He, Zhi Xing, Jianqing Sun, Di Liu, Yingxia Liu, Lei Liu, Wenjun Liu, Fumin Lei, Shi Weifeng, Gao George F.. Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds, 2014-2015 .VIROLOGICA SINICA, 2016, 31(4) : 300-305.  http://dx.doi.org/10.1007/s12250-016-3750-4
    shu

    Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds, 2014-2015

    cstr: 32224.14.s12250-016-3750-4
    • 1.

      Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Shenzhen 518112, China

    • 2.

      CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology Chinese Academy of Sciences, Wuhan 430071, China

    • 3.

      CAS Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

    • 4.

      Institute of Pathogen Biology, Taishan Medical College, Taishan 271000, China

    • 5.

      CAS Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

    • 6.

      Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China

    • 7.

      Research Institute of Experimental and Clinical Medicine, Novosibirsk State University, Novosibirsk 630090, Russia

    • 8.

      Qinghai Lake National Nature Reserve, State Forestry Administration, Xining 810007, China

    • 9.

      Office of Director-General, Chinese Center for Disease Control and Prevention (China CDC), and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Zhejiang University, Hangzhou 310058, China

    • Corresponding author: Yuhai Bi, Beeyh@im.ac.cn, ORCID: 0000-0002-5595-363X
    • Shi Weifeng, ORCID: 0000-0002-8717-2942
    • These authors contributed equally to this article.
    • Received Date: 22 February 2016
      Accepted Date: 08 June 2016
      Published Date: 30 June 2016
      Available online: 01 August 2016
    • A novel Clade 2.3.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to 2015. Based on the genetic and phylogenetic analyses, the viruses possess a stable gene constellation with a Clade 2.3.2.1c HA, a H9N2-derived PB2 gene and the other six genes of Asian H5N1-origin. The Clade 2.3.2.1c H5N1 reassortants displayed a high genetic relationship to a human H5N1 strain (A/Alberta/01/2014). Further analysis showed that similar viruses have been circulating in wild birds in China, Russia, Dubai (Western Asia), Bulgaria and Romania (Europe), as well as domestic poultry in some regions of Africa. The affected areas include the Central Asian, East Asian-Australasian, West Asian-East African, and Black Sea/Mediterranean flyways. These results show that the novel Clade 2.3.2.1c reassortant viruses are circulating worldwide and may have gained a selective advantage in migratory birds, thus posing a serious threat to wild birds and potentially humans.
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    • 10.1007s12250-016-3750-4.zip

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      Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds, 2014-2015

        Corresponding author: Yuhai Bi, Beeyh@im.ac.cn
      • Shi Weifeng, ORCID: 0000-0002-8717-2942
      • 1. Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Shenzhen 518112, China
      • 2. CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology Chinese Academy of Sciences, Wuhan 430071, China
      • 3. CAS Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
      • 4. Institute of Pathogen Biology, Taishan Medical College, Taishan 271000, China
      • 5. CAS Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
      • 6. Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China
      • 7. Research Institute of Experimental and Clinical Medicine, Novosibirsk State University, Novosibirsk 630090, Russia
      • 8. Qinghai Lake National Nature Reserve, State Forestry Administration, Xining 810007, China
      • 9. Office of Director-General, Chinese Center for Disease Control and Prevention (China CDC), and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Zhejiang University, Hangzhou 310058, China
      • Received Date: 22 February 2016
      • Accepted Date: 08 June 2016
      • Published Date: 30 June 2016

      Abstract: A novel Clade 2.3.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to 2015. Based on the genetic and phylogenetic analyses, the viruses possess a stable gene constellation with a Clade 2.3.2.1c HA, a H9N2-derived PB2 gene and the other six genes of Asian H5N1-origin. The Clade 2.3.2.1c H5N1 reassortants displayed a high genetic relationship to a human H5N1 strain (A/Alberta/01/2014). Further analysis showed that similar viruses have been circulating in wild birds in China, Russia, Dubai (Western Asia), Bulgaria and Romania (Europe), as well as domestic poultry in some regions of Africa. The affected areas include the Central Asian, East Asian-Australasian, West Asian-East African, and Black Sea/Mediterranean flyways. These results show that the novel Clade 2.3.2.1c reassortant viruses are circulating worldwide and may have gained a selective advantage in migratory birds, thus posing a serious threat to wild birds and potentially humans.

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