Conservative Evolution of Hepatitis B Virus Precore and Core Gene During Immune Tolerant Phase in Intrafamilial Transmission

• Yuqian Luo ^1, , 
• Le Zhang ^1, , 
• Yimin Dai ² , 
• Yali Hu ² , 
• Biyun Xu ³ , 
• Yi-Hua Zhou ^{1,4 ,,}

cstr: 32224.14.s12250-020-00194-6

• 1.

  Department of Laboratory Medicine, Nanjing Drum Tower Hospital and Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing 210008, China

• 2.

  Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China

• 3.

  Department of Biostatistics, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China

• 4.

  Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing Medical University, Nanjing 210008, China

• Corresponding author: Yi-Hua Zhou, zgr03summer@126.com, ORCID: 0000-0001-8880-0392
  
• Yuqian Luo and Le Zhang have contributed equally to this work