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Citation: Xueyu Wang, Zhiqiang Wei, Yongfang Jiang, Zhongji Meng, Mengji Lu. mTOR Signaling: The Interface Linking Cellular Metabolism and Hepatitis B Virus Replication [J].VIROLOGICA SINICA, 2021, 36(6) : 1303-1314.  http://dx.doi.org/10.1007/s12250-021-00450-3

mTOR Signaling: The Interface Linking Cellular Metabolism and Hepatitis B Virus Replication

  • Corresponding author: Zhongji Meng, zhongji.meng@taihehospital.com, ORCID: 0000-0003-0401-535X
    Mengji Lu, mengji.lu@uni-due.de, ORCID: 0000-0003-4287-9941
  • Received Date: 05 May 2021
    Accepted Date: 24 August 2021
    Published Date: 28 September 2021
    Available online: 01 December 2021
  • Mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that includes mTOR complex (mTORC) 1 and mTORC2. The mTOR pathway is activated in viral hepatitis, including hepatitis B virus (HBV) infection-induced hepatitis. Currently, chronic HBV infection remains one of the most serious public health issues worldwide. The unavailability of effective therapeutic strategies for HBV suggests that clarification of the pathogenesis of HBV infection is urgently required. Increasing evidence has shown that HBV infection can activate the mTOR pathway, indicating that HBV utilizes or hijacks the mTOR pathway to benefit its own replication. Therefore, the mTOR signaling pathway might be a crucial target for controlling HBV infection. Here, we summarize and discuss the latest findings from model biology research regarding the interaction between the mTOR signaling pathway and HBV replication.


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    mTOR Signaling: The Interface Linking Cellular Metabolism and Hepatitis B Virus Replication

      Corresponding author: Zhongji Meng, zhongji.meng@taihehospital.com
      Corresponding author: Mengji Lu, mengji.lu@uni-due.de
    • 1. Department of Infectious Diseases, The Second Xiangya Hospital, Central South University, Changsha 410011, China
    • 2. Institute of Virology, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany
    • 3. Institute of Biomedical Research, Hubei Clinical Research Center for Precise Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
    • 4. Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China

    Abstract: 

    Mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that includes mTOR complex (mTORC) 1 and mTORC2. The mTOR pathway is activated in viral hepatitis, including hepatitis B virus (HBV) infection-induced hepatitis. Currently, chronic HBV infection remains one of the most serious public health issues worldwide. The unavailability of effective therapeutic strategies for HBV suggests that clarification of the pathogenesis of HBV infection is urgently required. Increasing evidence has shown that HBV infection can activate the mTOR pathway, indicating that HBV utilizes or hijacks the mTOR pathway to benefit its own replication. Therefore, the mTOR signaling pathway might be a crucial target for controlling HBV infection. Here, we summarize and discuss the latest findings from model biology research regarding the interaction between the mTOR signaling pathway and HBV replication.