Correction to: Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Landscape in Neuronal Cells During JEV Infection

Mengyuan Li; Jiali Yang; Chuantao Ye; Peiyu Bian; Xiaofei Yang; Haijun Zhang; Chuanyu Luo; Zhifeng Xue; Yingfeng Lei; Jianqi Lian

doi:10.1007/s12250-021-00468-7

Corresponding author: Yingfeng Lei, yflei@fmmu.edu.cn

Corresponding author: Jianqi Lian, lianjq@fmmu.edu.cn

1. Department of Infectious Diseases, Tangdu Hospital, Air Force Medical University, Xi'an 710038, China

2. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi'an 710069, China

3. Department of Neurology, Xijing Hospital, Air Force Medical University, Xi'an 710032, China

4. Pathogenic Biology, Medical College of Yan'an University, Yan'an 716000, China

5. Department of Microbiology, School of Preclinical Medicine, Air Force Medical University, Xi'an 710032, China

Published Date: 24 November 2021

Abstract:

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Correction to: Virologica Sinica

https://doi.org/10.1007/s12250-021-00445-0

In the original version of this article, one image in Fig. 4 was accidently duplicated during figure layout and the dilution rate was mislabeled. The correct Fig. 4 and its legend are given below:

Figure 4. PPP is indispensable for JEV replication. A Heatmap analysis of significantly changed metabolites associated with purine and pyrimidine metabolism. B–G Intervention of PPP by 6-AN significantly inhibits JEV replication in Neuro2a cell line and mouse primary neurons at 24 hpi. JEV mRNA levels in JEV-infected Neuro2a cells (B) and mouse primary neurons (E) treated with 6-AN at 24 hpi were detected by qPCR analysis. The level of mRNA expression was normalized with β-actin. The expression levels of viral protein NS3 in JEV-infected Neuro2a cells (C) and mouse primary neurons (F) were detected by Western blot analysis. Plaque formation assay shows the reduction of plaque generation in JEV-infected Neuro2a cells (D) and mouse primary neurons (G). 10³, 10⁴, 10⁵ and 10⁶ represented the dilution rate. H qPCR analysis of JEV mRNA level shows that anaplerosis of D-ribose 5-phosphate under 6-AN treatment condition could partially restore the viral replication. *P < 0.05; **P < 0.01

Figure (1) Relative (20)

Correction to: Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Landscape in Neuronal Cells During JEV Infection

Abstract

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