Citation: Jia-Tong Chang, Li-Bo Liu, Pei-Gang Wang, Jing An. Single-cell RNA sequencing to understand host-virus interactions .VIROLOGICA SINICA, 2024, 39(1) : 1-8.

Single-cell RNA sequencing to understand host-virus interactions

  • Corresponding author: Pei-Gang Wang,
    Jing An,
  • Received Date: 08 March 2023
    Accepted Date: 23 November 2023
    Available online: 25 November 2023
  • Single-cell RNA sequencing (scRNA-seq) has allowed for the profiling of host and virus transcripts and host-virus interactions at single-cell resolution. This review summarizes the existing scRNA-seq technologies together with their strengths and weaknesses. The applications of scRNA-seq in various virological studies are discussed in depth, which broaden the understanding of the immune atlas, host-virus interactions, and immune repertoire. scRNA-seq can be widely used for virology in the near future to better understand the pathogenic mechanisms and discover more effective therapeutic strategies.

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    Single-cell RNA sequencing to understand host-virus interactions

      Corresponding author: Pei-Gang Wang,
      Corresponding author: Jing An,
    • Department of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China

    Abstract: Single-cell RNA sequencing (scRNA-seq) has allowed for the profiling of host and virus transcripts and host-virus interactions at single-cell resolution. This review summarizes the existing scRNA-seq technologies together with their strengths and weaknesses. The applications of scRNA-seq in various virological studies are discussed in depth, which broaden the understanding of the immune atlas, host-virus interactions, and immune repertoire. scRNA-seq can be widely used for virology in the near future to better understand the pathogenic mechanisms and discover more effective therapeutic strategies.

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