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Volume 39 Issue 1
February 2024
    Citation: Jia Li, Yong Lin, Xueyu Wang, Mengji Lu. Interconnection of cellular autophagy and endosomal vesicle trafficking and its role in hepatitis B virus replication and release .VIROLOGICA SINICA, 2024, 39(1) : 24-30.  http://dx.doi.org/10.1016/j.virs.2024.01.001
    shu

    Interconnection of cellular autophagy and endosomal vesicle trafficking and its role in hepatitis B virus replication and release

    • a. Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, 45122, Germany;

    • b. Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Chongqing Medical University, Chongqing, 400016, China;

    • c. The Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310000, China

    • Corresponding author: Mengji Lu, mengji.lu@uni-due.de
    • Received Date: 07 September 2023
      Accepted Date: 06 January 2024
      Available online: 09 January 2024
    • Hepatitis B virus (HBV) produces and releases various particle types, including complete virions, subviral particles with envelope proteins, and naked capsids. Recent studies demonstrate that HBV exploits distinct intracellular membrane trafficking pathways, including the endosomal vesicle trafficking and autophagy pathway, to assemble and release viral and subviral particles. Herein, we summarize the findings about the distinct roles of autophagy and endosomal membrane trafficking and the interaction of both pathways in HBV replication, assembly, and release.
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      Interconnection of cellular autophagy and endosomal vesicle trafficking and its role in hepatitis B virus replication and release

        Corresponding author: Mengji Lu, mengji.lu@uni-due.de
      • a. Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, 45122, Germany;
      • b. Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Chongqing Medical University, Chongqing, 400016, China;
      • c. The Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310000, China
      • Received Date: 07 September 2023
      • Accepted Date: 06 January 2024

      Abstract: Hepatitis B virus (HBV) produces and releases various particle types, including complete virions, subviral particles with envelope proteins, and naked capsids. Recent studies demonstrate that HBV exploits distinct intracellular membrane trafficking pathways, including the endosomal vesicle trafficking and autophagy pathway, to assemble and release viral and subviral particles. Herein, we summarize the findings about the distinct roles of autophagy and endosomal membrane trafficking and the interaction of both pathways in HBV replication, assembly, and release.

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