Citation: Yi Yin, Yi Zhang, Lelin Sun, Shuqiang Wang, Yong Zeng, Bo Gong, Lulin Huang, Yongquan He, Zhenglin Yang. Association analysis of genetic variants in critical patients with COVID-19 and validation in a Chinese population .VIROLOGICA SINICA, 2024, 39(2) : 347-350.  http://dx.doi.org/10.1016/j.virs.2024.02.004

Association analysis of genetic variants in critical patients with COVID-19 and validation in a Chinese population

  • Highlights
    1. Single-nucleotide polymorphisms in critical patients with COVID-19 conducted worldwide were validated in Chinese population.
    2. Variants in DPP9 and near RNU2-47P and TYRP1 showed the strongest associated signals with COVID-19 severity in Chinese population.
    3. Rs1886814 in FOXP4 was correlated with COVID-19 severity in Chinese and other populations.

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  • 10.1016j.virs.2024.02.004-ESM.docx
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    Association analysis of genetic variants in critical patients with COVID-19 and validation in a Chinese population

      Corresponding author: Lulin Huang, huangluling@yeah.net
      Corresponding author: Yongquan He, yongquanhe2012@163.com
      Corresponding author: Zhenglin Yang, yangzhenglin@cashq.ac.cn
    • a. Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610213, China;
    • b. Sichuan Provincial Key Laboratory for Human Disease Gene Study, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China;
    • c. Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China;
    • d. University of Chinese Academy of Sciences, Beijing, 100049, China;
    • e. Infectious Disease Department, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China;
    • f. Department of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China

    Abstract: Highlights
    1. Single-nucleotide polymorphisms in critical patients with COVID-19 conducted worldwide were validated in Chinese population.
    2. Variants in DPP9 and near RNU2-47P and TYRP1 showed the strongest associated signals with COVID-19 severity in Chinese population.
    3. Rs1886814 in FOXP4 was correlated with COVID-19 severity in Chinese and other populations.

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