Citation: Yuwei He, Chuting Zeng, Shuyan Tan, Xin Zhang, Silin Xiang, Chumin Liang, Shanshan Gao, Baisheng Li, Jing Lu. Viral kinetics of the Chikungunya virus ESCA-MAL lineage during the 2025 Guangdong outbreak .VIROLOGICA SINICA, 2026, 41(4) : 988-992.  http://dx.doi.org/10.1016/j.virs.2026.06.004

Viral kinetics of the Chikungunya virus ESCA-MAL lineage during the 2025 Guangdong outbreak

  • Corresponding author: Baisheng Li, libsn@126.com
    Jing Lu, jimlu0331@163.com
  • Received Date: 19 February 2026
    Accepted Date: 04 June 2026
    Available online: 09 June 2026
  • Highlights
    1 ECSA-MAL lineage of CHIKV shows robust replication and rapid clearance.
    2 Peak venous viremia (median 2.3 × 107 copies/mL) occurs on day 1 of symptom onset.
    3 Older age is significantly associated with higher peak viral loads.
    4 Longitudinal monitoring of capillary blood reveals viral clearance by day 6.

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    3. De Souza, W.M., Lecuit, M., Weaver, S.C., 2025. Chikungunya virus and other emerging arthritogenic alphaviruses. Nat Rev Microbiol, 23, 585-601.

    4. Gong, W., Wang, D., Chen, Q., Zhong, S., Shi, X., Peng, B., 2025. Outbreak of Chikungunya Virus with Aedes albopictus-Adaptive Mutations - Guangdong Province, China, 2025. China CDC Wkly, 7, 1528-1532.

    5. Kalyanasundram, J., Zawawi, Z.M., Kamel, K.A., Aroidoss, E.T., Ellan, K., Anasir, M.I., Azizan, M.A., Zulkifli, M.M.S., Zain, R.M., 2024. Emergence of ECSA-IOL E1-K211E/E2-V264A Lineage of Chikungunya virus during Malaysian 2021 outbreak. BMC Infect Dis, 24, 1199.

    6. Khongwichit, S., Chuchaona, W., Korkong, S., Wongsrisang, L., Thongmee, T., Poovorawan, Y., 2025. Chikungunya virus in Thailand (2020-2023): Epidemiology, clinical features, and genomic insights. PLoS Negl Trop Dis, 19, e0013548.

    7. Nainggolan, L., Dewi, B.E., Hakiki, A., Pranata, A.J., Sudiro, T.M., Martina, B., Van Gorp, E., 2023. Association of viral kinetics, infection history, NS1 protein with plasma leakage among Indonesian dengue infected patients. PLoS One, 18, e0285087.

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    11. Sourisseau, M., Schilte, C., Casartelli, N., Trouillet, C., Guivel-Benhassine, F., Rudnicka, D., Sol-Foulon, N., Le Roux, K., Prevost, M.C., Fsihi, H., Frenkiel, M.P., Blanchet, F., Afonso, P.V., Ceccaldi, P.E., Ozden, S., Gessain, A., Schuffenecker, I., Verhasselt, B., Zamborlini, A., Saib, A., Rey, F.A., Arenzana-Seisdedos, F., Despres, P., Michault, A., Albert, M.L., Schwartz, O., 2007. Characterization of reemerging chikungunya virus. PLoS Pathog, 3, e89.

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    Viral kinetics of the Chikungunya virus ESCA-MAL lineage during the 2025 Guangdong outbreak

      Corresponding author: Baisheng Li, libsn@126.com
      Corresponding author: Jing Lu, jimlu0331@163.com
    • a. School of Public Health, Sun Yat-sen University, Guangzhou 510080, China;
    • b. School of Biomedical and Pharmaceutical Specialty, Shantou University, Shantou 515063, China;
    • c. Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China;
    • d. Guangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response, Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China;
    • e. The Second People's Hospital of Foshan, Foshan 528000, China;
    • f. School of Public Health, Southern Medical University, Guangzhou 510515, China;
    • g. Jiangmen Central Hospital, Jiangmen 529000, China

    Abstract: Highlights
    1 ECSA-MAL lineage of CHIKV shows robust replication and rapid clearance.
    2 Peak venous viremia (median 2.3 × 107 copies/mL) occurs on day 1 of symptom onset.
    3 Older age is significantly associated with higher peak viral loads.
    4 Longitudinal monitoring of capillary blood reveals viral clearance by day 6.

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