Biological and M olecular Biological Characterization of W heat Yellow M osaic an d W heat Spindle Streak Mosaic Bymovirases

In order to investigate the stress response in the cells infected with Hantaan virus and the relationship between the expression of HSP70 and the virus replication, the Vero E6 cells infected with Hantaan virus (A9 strain) were detected by immunohistochemistry and in situ hybridization. The results show that the expression of HSP70 can be induced in the cells 4 hours after Hantaan virus infection and lasted until the fifth days after infection. The distribution of HSP70 also varied. It suggests that the expression of HSP70 can be induced directly by Hantaan virus.