Citation: LI Yong, YANG ZI, LIU Jian-jun, GUO Guang-shong, XIAO Hong, WEN Li. L6565 M ouse Leukemia Induced by L6565 Murine Leukemi a Virus .VIROLOGICA SINICA, 2001, 16(3) : 261-264.

L6565 M ouse Leukemia Induced by L6565 Murine Leukemi a Virus

  • Available online: 05 September 2001
  • Suckling mice were inoculated with L6565 blLV for researehlng the pathogeny of L6565 moL!se Leukemia Afterinoeulatica~,叽emol3y,eⅧ sacrificed r3r week.Theperipheral blood,thymus,[ymp畸node, spleen and liver weTe removed from l’lflOIl~.|I11e tissues were used to observe tIl0 pathological changes and to detect1.6565 MLV RNA by RT-PC~ .At 3~5 weeks postinoeulation.routine thynms.1ymphy node began to swell,And IIIOU~ leukemia was indueed at 10~12 weeks postinoeulatlon.L6565 MLV RNA Ⅵ∞ detected first inⅡl0use thymus and s een at the se~nd week曲er inoculadon,and the viral RNA *,vaS detected in rnanv /131iillle oigalls 8s time goes on.The results sh㈣d that L6565 l/lOUSe leukemia COIlld be jnduced by L6565 naalne leukemia、TirllS,and it is related to the transformation of lvmph0cyte by 1.6565 MLV.

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    L6565 M ouse Leukemia Induced by L6565 Murine Leukemi a Virus

    • 1. I贵阳医学院免疫学教研室.贵州贵阳550004~ 2.武汉大学医学院病毒学研究所.湖北武汉43007 3武汉太学中南医院病理科,湖北武汉430071

    Abstract: Suckling mice were inoculated with L6565 blLV for researehlng the pathogeny of L6565 moL!se Leukemia Afterinoeulatica~,叽emol3y,eⅧ sacrificed r3r week.Theperipheral blood,thymus,[ymp畸node, spleen and liver weTe removed from l’lflOIl~.|I11e tissues were used to observe tIl0 pathological changes and to detect1.6565 MLV RNA by RT-PC~ .At 3~5 weeks postinoeulation.routine thynms.1ymphy node began to swell,And IIIOU~ leukemia was indueed at 10~12 weeks postinoeulatlon.L6565 MLV RNA Ⅵ∞ detected first inⅡl0use thymus and s een at the se~nd week曲er inoculadon,and the viral RNA *,vaS detected in rnanv /131iillle oigalls 8s time goes on.The results sh㈣d that L6565 l/lOUSe leukemia COIlld be jnduced by L6565 naalne leukemia、TirllS,and it is related to the transformation of lvmph0cyte by 1.6565 MLV.

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