Citation: SUN Xiao, XIE Jian-ruing, ZHOU Shi-xin, XIE Xue-ying, LU Zu-hong. Genome Comparison Between SARS—associated coronavirus andOther Coronaviruses .VIROLOGICA SINICA, 2003, 18(4) : 335-339.

Genome Comparison Between SARS—associated coronavirus andOther Coronaviruses

  • Available online: 05 August 2003
  • Abstract:The genome sequences of SARS.associated coronavirus (SARS.COV)were compared witIlother Coronaviruses.Similar sequences were found by searching biomolecular databases.Sequenceanalysis showed that SARS.CoV had similar genomi c organization and structural proteins whilecompared with other Coronaviruses.SARS.CoV is related to other known Coronaviruses.But therewere some specific sequences in SARS.CoV genome.Th e virulence of SARS may deftve fromvaxi~ions of ORF l a an d S protein an d the specificity of some nonstructural proteins.Th e result of wordfrequency an alysis indicated that SARS.CoV does not closely resemble an y of kn own Coronaviruses.

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    Genome Comparison Between SARS—associated coronavirus andOther Coronaviruses

    • 1. Department ofBiological Science&Medical Engineering,Southeast University,Nanfing 210096,China

    Abstract: Abstract:The genome sequences of SARS.associated coronavirus (SARS.COV)were compared witIlother Coronaviruses.Similar sequences were found by searching biomolecular databases.Sequenceanalysis showed that SARS.CoV had similar genomi c organization and structural proteins whilecompared with other Coronaviruses.SARS.CoV is related to other known Coronaviruses.But therewere some specific sequences in SARS.CoV genome.Th e virulence of SARS may deftve fromvaxi~ions of ORF l a an d S protein an d the specificity of some nonstructural proteins.Th e result of wordfrequency an alysis indicated that SARS.CoV does not closely resemble an y of kn own Coronaviruses.

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